Dr Josie Parker

Penodiad Er Anrhydedd (Gwyddorau Dynol ac Iechyd)

Faculty of Medicine Health and Life Science

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Ar gael ar gyfer Goruchwyliaeth Ôl-raddedig

Trosolwg

Mae Dr Josie Parker yn Uwch-swyddog ymchwil yn Ysgol Feddygaeth Prifysgol Abertawe. Mae ei hymchwil yn canolbwyntio ar ensymau sytocrom P450 ac ymwrthedd gwrthffyngol.

Ymunodd Josie â Phrifysgol Abertawe fel Ymchwilydd yn 2005. Enillodd BSc (Anrh) mewn Geneteg yn 2010 a dyfarnwyd PhD iddi am ‘An Investigation of the Role of Cytochromes P450 in Mycobacteria’ yn 2006 gan Brifysgol Cymru, Aberystwyth.

Meysydd Arbenigedd

Ensymau sytocrom P450
Ymwrthedd gwrthffyngol
Dadansoddi sterolau (GC-MS)
Bioleg foleciwlaidd
Mynegi proteinau mewn modd heterologaidd

Uchafbwyntiau Gyrfa

Diddordebau Addysgu

Mae Josie yn un o Gymrodorion yr Academi Addysg Uwch ac yn Llysgennad STEM. Mae hi'n addysgu ar raglenni geneteg a biocemeg ar lefelau BSc a Meistr.

Mae gweithgareddau addysgu Josie yn canolbwyntio ar feysydd microbioleg, mecanweithiau ymwrthedd i gyffuriau gwrthficrobaidd, biocemeg sytocrom P450, ffarmacogenomeg a sgiliau labordy biofeddygol.

Mae Josie yn goruchwylio prosiectau israddedig mewn Microbioleg a Biotechnoleg, yn ogystal â lleoliadau profiad gwaith ac ysgoloriaethau ymchwil haf mewn labordai.

Ymchwil Cydweithrediadau

Cyhoeddiadau

Uchafbwyntiau Ymchwil

Rybak, J., Barker, K., Muñoz, J., Parker, J., Ahmad, S., Mokaddas, E., Abdullah, A., Elhagracy, R., Kelly, S., Cuomo, C., & Rogers, P. (2022). In vivo emergence of high-level resistance during treatment reveals the first identified mechanism of amphotericin B resistance in Candida auris. Clinical Microbiology and Infection, 28(6), 838-843.
https://doi.org/10.1016/j.cmi.2021.11.024, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa59077
http://dx.doi.org/10.1016/j.cmi.2021.11.024
Aruanno, M., Gozel, S., Mouyna, I., Parker, J., Bachmann, D., Flamant, P., Coste, A., Sanglard, D., & Lamoth, F. (2021). Insights in the molecular mechanisms of an azole stress adapted laboratory-generated Aspergillus fumigatus strain. Medical Mycology, 59(8), 763-772.
https://doi.org/10.1093/mmy/myaa118, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56258
Luna-Tapia, A., Parker, J., Kelly, S., & Palmer, G. (2021). Species-Specific Differences in C-5 Sterol Desaturase Function Influence the Outcome of Azole Antifungal Exposure. Antimicrobial Agents and Chemotherapy, 65(12)
https://doi.org/10.1128/aac.01044-21, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa58450
Ollinger, T., Vu, B., Murante, D., Parker, J., Simonicova, L., Doorley, L., Stamnes, M., Kelly, S., Rogers, P., Moye-Rowley, W., & Krysan, D. (2021). Loss-of-Function ROX1 Mutations Suppress the Fluconazole Susceptibility of upc2AΔ Mutation in Candida glabrata, Implicating Additional Positive Regulators of Ergosterol Biosynthesis. mSphere, 6(6)
https://doi.org/10.1128/msphere.00830-21, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa59074
Hull, C., Bader, O., Parker, J., Weig, M., Gross, U., Warrilow, A., Kelly, D., & Kelly, S. (2012). Two Clinical Isolates of Candida glabrata Exhibiting Reduced Sensitivity to Amphotericin B Both Harbor Mutations inERG2. Antimicrobial Agents and Chemotherapy, 56(12), 6417-6421.
https://doi.org/10.1128/aac.01145-12, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa13028
http://dx.doi.org/10.1128/aac.01145-12
Morgan, S., Pilia, N., Hewitt, M., Moses, R., Moseley, R., Lewis, P., Morrison, P., Kelly, S., Parker, J., Whitaker, D., Quantock, A., & Heard, C. (2020). Controlled in vitro delivery of voriconazole and diclofenac to the cornea using contact lenses for the treatment of Acanthamoeba keratitis. International Journal of Pharmaceutics, 579, 119102
https://doi.org/10.1016/j.ijpharm.2020.119102, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa53795
Rybak, J., Muñoz, J., Barker, K., Parker, J., Esquivel, B., Berkow, E., Lockhart, S., Gade, L., Palmer, G., White, T., Kelly, S., Cuomo, C., & Rogers, P. (2020). Mutations in TAC1B: a Novel Genetic Determinant of Clinical Fluconazole Resistance in Candida auris. mBio, 11(3)
https://doi.org/10.1128/mbio.00365-20, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa54319
Binjubair, F., Parker, J., Warrilow, A., Puri, K., Braidley, P., Tatar, E., Kelly, S., Kelly, D., & Simons, C. (2020). Small‐Molecule Inhibitors Targeting Sterol 14α‐Demethylase (CYP51): Synthesis, Molecular Modelling and Evaluation Against Candida albicans. ChemMedChem, 15(14), 1294-1309.
https://doi.org/10.1002/cmdc.202000250, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa54878
Furukawa, T., Rhijn, N., Fraczek, M., Gsaller, F., Davies, E., Carr, P., Gago, S., Fortune-Grant, R., Rahman, S., Gilsenan, J., Houlder, E., Kowalski, C., Raj, S., Paul, S., Cook, P., Parker, J., Kelly, S., Cramer, R., Latgé, J...., & Bromley, M. (2020). The negative cofactor 2 complex is a key regulator of drug resistance in Aspergillus fumigatus. Nature Communications, 11(1)
https://doi.org/10.1038/s41467-019-14191-1, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa53507
http://dx.doi.org/10.1038/s41467-019-14191-1
Rybak, J., Ge, W., Wiederhold, N., Parker, J., Kelly, S., Rogers, P., & Fortwendel, J. (2019). Mutations in hmg1, Challenging the Paradigm of Clinical Triazole Resistance in Aspergillus fumigatus. mBio, 10(2)
https://doi.org/10.1128/mbio.00437-19, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa49873
Warrilow, A., Nishimoto, A., Parker, J., Price, C., Flowers, S., Kelly, D., Rogers, P., & Kelly, S. (2019). The Evolution of Azole Resistance in Candida albicans Sterol 14α-Demethylase (CYP51) through Incremental Amino Acid Substitutions. Antimicrobial Agents and Chemotherapy, 63(5)
https://doi.org/10.1128/aac.02586-18, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa48946
Griffiths, W., Crick, P., Meljon, A., Theofilopoulos, S., Abdel-Khalik, J., Yutuc, E., Parker, J., Kelly, D., Kelly, S., Arenas, E., & Wang, Y. (2019). Additional pathways of sterol metabolism: Evidence from analysis of Cyp27a1−/− mouse brain and plasma. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 1864(2), 191-211.
https://doi.org/10.1016/j.bbalip.2018.11.006, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa46057
http://dx.doi.org/10.1016/j.bbalip.2018.11.006
Warrilow, A., Parker, J., Price, C., Rolley, N., Nes, W., Kelly, D., & Kelly, S. (2019). Isavuconazole and voriconazole inhibition of sterol 14α-demethylases (CYP51) from Aspergillus fumigatus and Homo sapiens. International Journal of Antimicrobial Agents
https://doi.org/10.1016/j.ijantimicag.2019.07.011, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa51096
Ahmad, S., Joseph, L., Parker, J., Asadzadeh, M., Kelly, S., Meis, J., & Khan, Z. (2018). ERG6 and ERG2 Are Major Targets Conferring Reduced Susceptibility to Amphotericin B in Clinical Candida glabrata Isolates in Kuwait. Antimicrobial Agents and Chemotherapy, 63(2), e01900-18
https://doi.org/10.1128/AAC.01900-18, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa45903
Zhou, W., Warrilow, A., Thomas, C., Ramos, E., Parker, J., Price, C., Vanderloop, B., Fisher, P., Loftis, M., Kelly, D., Kelly, S., & Nes, W. (2018). Functional importance for developmental regulation of sterol biosynthesis in Acanthamoeba castellanii. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 1863(10), 1164-1178.
https://doi.org/10.1016/j.bbalip.2018.07.004, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa41148
Luna-Tapia, A., Willems, H., Parker, J., Tournu, H., Barker, K., Nishimoto, A., Rogers, P., Kelly, S., Peters, B., & Palmer, G. (2018). Loss of Upc2p-Inducible ERG3 Transcription Is Sufficient To Confer Niche-Specific Azole Resistance without Compromising Candida albicans Pathogenicity. mBio, 9(3), e00225-18
https://doi.org/10.1128/mBio.00225-18, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa40336
Colley, T., Sehra, G., Chowdhary, A., Alanio, A., Kelly, S., Kizawa, Y., Armstrong-James, D., Fisher, M., Warrilow, A., Parker, J., Kelly, D., Kimura, G., Nishimoto, Y., Sunose, M., Onions, S., Crepin, D., Lagasse, F., Crittall, M., Shannon, J...., & Rapeport, G. (2018). In Vitro and In Vivo Efficacy of a Novel and Long-Acting Fungicidal Azole, PC1244, on Aspergillus fumigatus Infection. Antimicrobial Agents and Chemotherapy, 62(5), AAC.01941-17
https://doi.org/10.1128/aac.01941-17, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa38876
http://dx.doi.org/10.1128/aac.01941-17
Butts, A., DeJarnette, C., Peters, T., Parker, J., Kerns, M., Eberle, K., Kelly, S., & Palmer, G. (2017). Target Abundance-Based Fitness Screening (TAFiS) Facilitates Rapid Identification of Target-Specific and Physiologically Active Chemical Probes. mSphere, 2(5), e00379-17
https://doi.org/10.1128/mSphere.00379-17, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa36657
Warrilow, A., Parker, J., Price, C., Garvey, E., Hoekstra, W., Schotzinger, R., Wiederhold, N., Nes, W., Kelly, D., & Kelly, S. (2017). The Tetrazole VT-1161 Is a Potent Inhibitor of Trichophyton rubrum through Its Inhibition of T. rubrum CYP51. Antimicrobial Agents and Chemotherapy, 61(7), e00333-17
https://doi.org/10.1128/AAC.00333-17, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa34176
Colley, T., Alanio, A., Kelly, S., Sehra, G., Kizawa, Y., Warrilow, A., Parker, J., Kelly, D., Kimura, G., Anderson-Dring, L., Nakaoki, T., Sunose, M., Onions, S., Crepin, D., Lagasse, F., Crittall, M., Shannon, J., Cooke, M., Bretagne, S...., & Rapeport, G. (2017). In vitro and in vivo antifungal profile of a novel and long acting inhaled azole, PC945, on Aspergillus fumigatus infection. Antimicrobial Agents and Chemotherapy, AAC.02280-16
https://doi.org/10.1128/AAC.02280-16, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32189
Rybak, J., Dickens, C., Parker, J., Caudle, K., Manigaba, K., Whaley, S., Nishimoto, A., Luna-Tapia, A., Roy, S., Zhang, Q., Barker, K., Palmer, G., Sutter, T., Homayouni, R., Wiederhold, N., Kelly, S., & Rogers, P. (2017). Loss of C-5 Sterol Desaturase Activity Results in Increased Resistance to Azole and Echinocandin Antifungals in a Clinical Isolate of Candida parapsilosis. Antimicrobial Agents and Chemotherapy, 61(9), AAC.00651-17
https://doi.org/10.1128/aac.00651-17, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa34548
http://dx.doi.org/10.1128/aac.00651-17
Warrilow, A., Parker, J., Price, C., Nes, W., Garvey, E., Hoekstra, W., Schotzinger, R., Kelly, D., & Kelly, S. (2016). The Investigational Drug VT-1129 Is a Highly Potent Inhibitor of Cryptococcus Species CYP51 but Only Weakly Inhibits the Human Enzyme. Antimicrobial Agents and Chemotherapy, 60(8), 4530-4538.
https://doi.org/10.1128/AAC.00349-16, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa29154
Warrilow, A., Price, C., Parker, J., Rolley, N., Smyrniotis, C., Hughes, D., Thoss, V., Nes, W., Kelly, D., Holman, T., & Kelly, S. (2016). Azole Antifungal Sensitivity of Sterol 14α-Demethylase (CYP51) and CYP5218 from Malassezia globosa. Scientific Reports, 6(1)
https://doi.org/10.1038/srep27690, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa34335
McCourt, P., Liu, H., Parker, J., Gallo-Ebert, C., Donigan, M., Bata, A., Giordano, C., Kelly, S., Nickels, J., & Parker, J. (2016). Proper Sterol Distribution Is Required for Candida albicans Hyphal Formation and Virulence. G3 Genes|Genomes|Genetics, 6(11)
https://doi.org/10.1534/g3.116.033969, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa31346
Derbyshire, M., Michaelson, L., Parker, J., Kelly, S., Thacker, U., Powers, S., Bailey, A., Hammond-Kosack, K., Courbot, M., & Rudd, J. (2015). Analysis of cytochrome b5 reductase-mediated metabolism in the phytopathogenic fungus Zymoseptoria tritici reveals novel functionalities implicated in virulence. Fungal Genetics and Biology
https://doi.org/10.1016/j.fgb.2015.05.008, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa22091
Berkow, E., Manigaba, K., Parker, J., Barker, K., Kelly, S., & Rogers, P. (2015). Multidrug Transporters and Alterations in Sterol Biosynthesis Contribute to Azole Antifungal Resistance in Candida parapsilosis. Antimicrobial Agents and Chemotherapy, 59(10), 5942-5950.
https://doi.org/10.1128/aac.01358-15, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa22523
http://dx.doi.org/10.1128/aac.01358-15
Warrilow, A., Parker, J., Price, C., Nes, W., Kelly, S., & Kelly, D. (2015). In Vitro Biochemical Study of CYP51-Mediated Azole Resistance in Aspergillus fumigatus. Antimicrobial Agents and Chemotherapy, 59(12), 7771-7778.
https://doi.org/10.1128/aac.01806-15, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa23614
http://dx.doi.org/10.1128/aac.01806-15
Lamb, D., Warrilow, A., Rolley, N., Parker, J., Nes, W., Smith, S., Kelly, D., & Kelly, S. (2015). Azole Antifungal Agents To Treat the Human Pathogens Acanthamoeba castellanii and Acanthamoeba polyphaga through Inhibition of Sterol 14α-Demethylase (CYP51). Antimicrobial Agents and Chemotherapy, 59(8), 4707-4713.
https://doi.org/10.1128/AAC.00476-15, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa31514
http://aac.asm.org/content/59/8/4707.full.pdf+html
Price, C., Warrilow, A., Parker, J., Mullins, J., Nes, W., Kelly, D., Kelly, S., & Schottel, J. (2015). Novel Substrate Specificity and Temperature-Sensitive Activity of Mycosphaerella graminicola CYP51 Supported by the Native NADPH Cytochrome P450 Reductase. Applied and Environmental Microbiology, 81(10), 3379-3386.
https://doi.org/10.1128/AEM.03965-14, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa20704
Price, C., Parker, J., Warrilow, A., Kelly, D., & Kelly, S. (2015). Azole fungicides - understanding resistance mechanisms in agricultural fungal pathogens. Pest Management Science, n/a-n/a.
https://doi.org/10.1002/ps.4029, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa20922
Warrilow, A., Hull, C., Parker, J., Garvey, E., Hoekstra, W., Moore, W., Schotzinger, R., Kelly, D., Kelly, S., & Hull, C. (2014). The Clinical Candidate VT-1161 Is a Highly Potent Inhibitor of Candida albicans CYP51 but Fails To Bind the Human Enzyme. Antimicrobial Agents and Chemotherapy, 58(12), 7121-7127.
https://doi.org/10.1128/AAC.03707-14, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa18693
Parker, J., Warrilow, A., Price, C., Mullins, J., Kelly, D., & Kelly, S. (2014). Resistance to antifungals that target CYP51. Journal of Chemical Biology, 7(4), 143-161.
https://doi.org/10.1007/s12154-014-0121-1, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa18694
Warrilow, A., Hull, C., Rolley, N., Parker, J., Nes, W., Smith, S., Kelly, D., & Kelly, S. (2014). Clotrimazole as a Potent Agent for Treating the Oomycete Fish Pathogen Saprolegnia parasitica through Inhibition of Sterol 14 -Demethylase (CYP51). Applied and Environmental Microbiology, 80(19), 6154-6166.
https://doi.org/10.1128/AEM.01195-14, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa18616
Fan, J., Urban, M., Parker, J., Brewer, H., Kelly, S., Hammond-Kosack, K., Fraaije, B., Liu, X., & Cools, H. (2013). Characterization of the sterol 14α-demethylases of Fusarium graminearum identifies a novel genus-specific CYP51 function. New Phytologist-n/a.
https://doi.org/10.1111/NPH.12193, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa14421
Kelly, S., Kelly, D., Parker, J., & Warrilow, A. (2013). Azole Affinity of Sterol 14alpha-Demethylase (CYP51) Enzymes from Candida albicans and Homo sapiens. Antimicrobial Agents and Chemotherapy, 57(3)-1360.
https://doi.org/10.1128/AAC.02067-12, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa14415
Eddouzi, J., Parker, J., Vale-Silva, L., Coste, A., Ischer, F., Kelly, S., Manai, M., & Sanglard, D. (2013). Molecular Mechanisms of Drug Resistance in Clinical Candida Species Isolated from Tunisian Hospitals. Antimicrobial Agents and Chemotherapy, 57(7), 3182-3193.
https://doi.org/10.1128/AAC.00555-13, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa15187
Nie, D., Hoobler, E., Rai, G., Warrilow, A., Perry, S., Smyrniotis, C., Jadhav, A., Simeonov, A., Parker, J., Kelly, D., Maloney, D., Kelly, S., & Holman, T. (2013). Discovery of a Novel Dual Fungal CYP51/Human 5-Lipoxygenase Inhibitor: Implications for Anti-Fungal Therapy. PLoS ONE, 8(6)
https://doi.org/10.1371/journal.pone.0065928, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa15178
Vale-Silva, L., Coste, A., Ischer, F., Parker, J., Kelly, S., Pinto, E., & Sanglard, D. (2012). Azole Resistance by Loss of Function of the Sterol Δ5,6-Desaturase Gene (ERG3) in Candida albicans Does Not Necessarily Decrease Virulence. Antimicrobial Agents and Chemotherapy, 56(4), 1960-1968.
https://doi.org/10.1128/aac.05720-11, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa6836
Hull, C., Parker, J., Bader, O., Weig, M., Gross, U., Warrilow, A., Kelly, D., & Kelly, S. (2012). Facultative Sterol Uptake in an Ergosterol-Deficient Clinical Isolate of Candida glabrata Harboring a Missense Mutation inERG11and Exhibiting Cross-Resistance to Azoles and Amphotericin B. Antimicrobial Agents and Chemotherapy, 56(8), 4223-4232.
https://doi.org/10.1128/aac.06253-11, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa12338
http://dx.doi.org/10.1128/aac.06253-11
Cools, H., Mullins, J., Fraaije, B., Parker, J., Kelly, D., Lucas, J., & Kelly, S. (2011). Impact of Recently Emerged Sterol 14 alpha-Demethylase (CYP51) Variants of Mycosphaerella graminicola on Azole Fungicide Sensitivity. Applied and Environmental Microbiology, 77(11), 3830-3837.
https://doi.org/10.1128/AEM.00027-11, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa6846
Mullins, J., Parker, J., Cools, H., Togawa, R., Lucas, J., Fraaije, B., Kelly, D., & Kelly, S. (2011). Molecular Modelling of the Emergence of Azole Resistance in Mycosphaerella graminicola. PLoS ONE, 6(6), e20973
https://doi.org/10.1371/journal.pone.0020973, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa6839
Martel, C., Parker, J., Jackson, C., Warrilow, A., Rolley, N., Greig, C., Morris, S., Donnison, I., Kelly, D., Kelly, S., & Hull, C. (2011). Expression of bacterial levanase in yeast enables simultaneous saccharification and fermentation of grass juice to bioethanol. Bioresource Technology, 102(2), 1503-1508.
https://doi.org/10.1016/j.biortech.2010.07.099, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa6360
Martel, C., Parker, J., Bader, O., Weig, M., Gross, U., Warrilow, A., Rolley, N., Kelly, D., Kelly, S., & Hull, C. (2010). Identification and Characterization of Four Azole-Resistant erg3 Mutants of Candida albicans. Antimicrobial Agents and Chemotherapy, 54(11), 4527-4533.
https://doi.org/10.1128/AAC.00348-10, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa6358
Cools, H., Parker, J., Kelly, D., Lucas, J., Fraaije, B., & Kelly, S. (2010). Heterologous Expression of Mutated Eburicol 14α-Demethylase (CYP51) Proteins of Mycosphaerella graminicola To Assess Effects on Azole Fungicide Sensitivity and Intrinsic Protein Function. Applied and Environmental Microbiology, 76(9), 2866-2872.
https://doi.org/10.1128/aem.02158-09, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa6856
http://dx.doi.org/10.1128/aem.02158-09
Warrilow, A., Melo, N., Martel, C., Parker, J., Nes, W., Kelly, S., & Kelly, D. (2010). Expression, Purification, and Characterization of Aspergillus fumigatus Sterol 14alpha-Demethylase (CYP51) Isoenzymes A and B. Antimicrobial Agents and Chemotherapy, 54(10), 4225-4234.
https://doi.org/10.1128/AAC.00316-10, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa6354
Martel, C., Parker, J., Bader, O., Weig, M., Gross, U., Warrilow, A., Kelly, D., Kelly, S., Parker, J., & Hull, C. (2010). A Clinical Isolate of Candida albicans with Mutations in ERG11 (Encoding Sterol 14alpha-Demethylase) and ERG5 (Encoding C22 Desaturase) Is Cross Resistant to Azoles and Amphotericin B. Antimicrobial Agents and Chemotherapy, 54(9), 3578-3583.
https://doi.org/10.1128/AAC.00303-10, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa6353
Warrilow, A., Martel, C., Parker, J., Melo, N., Lamb, D., Nes, W., Kelly, D., Kelly, S., & Hull, C. (2010). Azole Binding Properties of Candida albicans Sterol 14alpha-Demethylase (CaCYP51). Antimicrobial Agents and Chemotherapy, 54(10), 4235-4245.
https://doi.org/10.1128/AAC.00587-10, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa6355
Martel, C., Parker, J., Warrilow, A., Rolley, N., Kelly, S., Kelly, D., Parker, J., Hull, C., & Warrilow, A. (2010). Complementation of a Saccharomyces cerevisiae ERG11/CYP51 (Sterol 14alpha-Demethylase) Doxycycline-Regulated Mutant and Screening of the Azole Sensitivity of Aspergillus fumigatus Isoenzymes CYP51A and CYP51B. Antimicrobial Agents and Chemotherapy, 54(11), 4920-4923.
https://doi.org/10.1128/AAC.00349-10, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa6356
Martel, C., Warrilow, A., Jackson, C., Mullins, J., Togawa, R., Parker, J., Morris, M., Donnison, I., Kelly, D., Kelly, S., Mullins, J., & Hull, C. (2010). Expression, purification and use of the soluble domain of Lactobacillus paracasei β-fructosidase to optimise production of bioethanol from grass fructans. Bioresource Technology, 101(12), 4395-4402.
https://doi.org/10.1016/j.biortech.2010.01.084, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa6359
Parker, J., Warrilow, A., Cools, H., Martel, C., Nes, W., Fraaije, B., Lucas, J., Kelly, D., Kelly, S., & Hull, C. (2010). Mechanism of Binding of Prothioconazole to Mycosphaerella graminicola CYP51 Differs from That of Other Azole Antifungals. Applied and Environmental Microbiology, 77(4), 1460-1465.
https://doi.org/10.1128/AEM.01332-10, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa6361
Parker, J., Merkamm, M., Manning, N., Pompon, D., Kelly, S., & Kelly, D. (2008). Differential Azole Antifungal Efficacies Contrasted Using a Saccharomyces cerevisiae Strain Humanized for Sterol 14 alpha-Demethylase at the Homologous Locus. Antimicrobial Agents and Chemotherapy, 52(10), 3597-3603.
https://doi.org/10.1128/AAC.00517-08, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa6835
Warrilow, A., Jackson, C., Parker, J., Marczylo, T., Kelly, D., Lamb, D., & Kelly, S. (2008). Identification, Characterization, and Azole-Binding Properties of Mycobacterium smegmatis CYP164A2, a Homolog of ML2088, the Sole Cytochrome P450 Gene of Mycobacterium leprae. Antimicrobial Agents and Chemotherapy, 53(3), 1157-1164.
https://doi.org/10.1128/AAC.01237-08, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa6351
Jackson, C., Lamb, D., Marczylo, T., Parker, J., Manning, N., Kelly, D., & Kelly, S. (2003). Conservation and cloning of CYP51: a sterol 14α-demethylase from Mycobacterium smegmatis. Biochemical and Biophysical Research Communications, 301(2), 558
https://doi.org/10.1016/S0006-291X(02)03078-4, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa6859
Kannan, A., Asner, S., Trachsel, E., Kelly, S., Parker, J., & Sanglard, D. (2019). Comparative Genomics for the Elucidation of Multidrug Resistance in Candida lusitaniae. mBio, 10(6)
https://doi.org/10.1128/mbio.02512-19, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa53151
Price, C., Warrilow, A., Rolley, N., Parker, J., Thoss, V., Kelly, D., Corcionivoschi, N., & Kelly, S. (2022). Cytochrome P450 168A1 from Pseudomonas aeruginosa is involved in the hydroxylation of biologically relevant fatty acids. PLOS ONE, 17(3), e0265227
https://doi.org/10.1371/journal.pone.0265227, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa59697

Holl Ymchwil

Erthyglau Cylchgronau

Rybak, J., Barker, K., Muñoz, J., Parker, J., Ahmad, S., Mokaddas, E., Abdullah, A., Elhagracy, R., Kelly, S., Cuomo, C., & Rogers, P. (2022). In vivo emergence of high-level resistance during treatment reveals the first identified mechanism of amphotericin B resistance in Candida auris. Clinical Microbiology and Infection, 28(6), 838-843.
https://doi.org/10.1016/j.cmi.2021.11.024, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa59077
http://dx.doi.org/10.1016/j.cmi.2021.11.024
Price, C., Warrilow, A., Rolley, N., Parker, J., Thoss, V., Kelly, D., Corcionivoschi, N., & Kelly, S. (2022). Cytochrome P450 168A1 from Pseudomonas aeruginosa is involved in the hydroxylation of biologically relevant fatty acids. PLOS ONE, 17(3), e0265227
https://doi.org/10.1371/journal.pone.0265227, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa59697
Ollinger, T., Vu, B., Murante, D., Parker, J., Simonicova, L., Doorley, L., Stamnes, M., Kelly, S., Rogers, P., Moye-Rowley, W., & Krysan, D. (2021). Loss-of-Function ROX1 Mutations Suppress the Fluconazole Susceptibility of upc2AΔ Mutation in Candida glabrata, Implicating Additional Positive Regulators of Ergosterol Biosynthesis. mSphere, 6(6)
https://doi.org/10.1128/msphere.00830-21, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa59074
Luna-Tapia, A., Parker, J., Kelly, S., & Palmer, G. (2021). Species-Specific Differences in C-5 Sterol Desaturase Function Influence the Outcome of Azole Antifungal Exposure. Antimicrobial Agents and Chemotherapy, 65(12)
https://doi.org/10.1128/aac.01044-21, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa58450
Aruanno, M., Gozel, S., Mouyna, I., Parker, J., Bachmann, D., Flamant, P., Coste, A., Sanglard, D., & Lamoth, F. (2021). Insights in the molecular mechanisms of an azole stress adapted laboratory-generated Aspergillus fumigatus strain. Medical Mycology, 59(8), 763-772.
https://doi.org/10.1093/mmy/myaa118, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56258
Furukawa, T., Rhijn, N., Fraczek, M., Gsaller, F., Davies, E., Carr, P., Gago, S., Fortune-Grant, R., Rahman, S., Gilsenan, J., Houlder, E., Kowalski, C., Raj, S., Paul, S., Cook, P., Parker, J., Kelly, S., Cramer, R., Latgé, J...., & Bromley, M. (2020). The negative cofactor 2 complex is a key regulator of drug resistance in Aspergillus fumigatus. Nature Communications, 11(1)
https://doi.org/10.1038/s41467-019-14191-1, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa53507
http://dx.doi.org/10.1038/s41467-019-14191-1
Binjubair, F., Parker, J., Warrilow, A., Puri, K., Braidley, P., Tatar, E., Kelly, S., Kelly, D., & Simons, C. (2020). Small‐Molecule Inhibitors Targeting Sterol 14α‐Demethylase (CYP51): Synthesis, Molecular Modelling and Evaluation Against Candida albicans. ChemMedChem, 15(14), 1294-1309.
https://doi.org/10.1002/cmdc.202000250, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa54878
Rybak, J., Muñoz, J., Barker, K., Parker, J., Esquivel, B., Berkow, E., Lockhart, S., Gade, L., Palmer, G., White, T., Kelly, S., Cuomo, C., & Rogers, P. (2020). Mutations in TAC1B: a Novel Genetic Determinant of Clinical Fluconazole Resistance in Candida auris. mBio, 11(3)
https://doi.org/10.1128/mbio.00365-20, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa54319
Morgan, S., Pilia, N., Hewitt, M., Moses, R., Moseley, R., Lewis, P., Morrison, P., Kelly, S., Parker, J., Whitaker, D., Quantock, A., & Heard, C. (2020). Controlled in vitro delivery of voriconazole and diclofenac to the cornea using contact lenses for the treatment of Acanthamoeba keratitis. International Journal of Pharmaceutics, 579, 119102
https://doi.org/10.1016/j.ijpharm.2020.119102, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa53795
Rybak, J., Ge, W., Wiederhold, N., Parker, J., Kelly, S., Rogers, P., & Fortwendel, J. (2019). Mutations in hmg1, Challenging the Paradigm of Clinical Triazole Resistance in Aspergillus fumigatus. mBio, 10(2)
https://doi.org/10.1128/mbio.00437-19, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa49873
Warrilow, A., Parker, J., Price, C., Rolley, N., Nes, W., Kelly, D., & Kelly, S. (2019). Isavuconazole and voriconazole inhibition of sterol 14α-demethylases (CYP51) from Aspergillus fumigatus and Homo sapiens. International Journal of Antimicrobial Agents
https://doi.org/10.1016/j.ijantimicag.2019.07.011, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa51096
Kannan, A., Asner, S., Trachsel, E., Kelly, S., Parker, J., & Sanglard, D. (2019). Comparative Genomics for the Elucidation of Multidrug Resistance in Candida lusitaniae. mBio, 10(6)
https://doi.org/10.1128/mbio.02512-19, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa53151
Griffiths, W., Crick, P., Meljon, A., Theofilopoulos, S., Abdel-Khalik, J., Yutuc, E., Parker, J., Kelly, D., Kelly, S., Arenas, E., & Wang, Y. (2019). Additional pathways of sterol metabolism: Evidence from analysis of Cyp27a1−/− mouse brain and plasma. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 1864(2), 191-211.
https://doi.org/10.1016/j.bbalip.2018.11.006, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa46057
http://dx.doi.org/10.1016/j.bbalip.2018.11.006
Warrilow, A., Nishimoto, A., Parker, J., Price, C., Flowers, S., Kelly, D., Rogers, P., & Kelly, S. (2019). The Evolution of Azole Resistance in Candida albicans Sterol 14α-Demethylase (CYP51) through Incremental Amino Acid Substitutions. Antimicrobial Agents and Chemotherapy, 63(5)
https://doi.org/10.1128/aac.02586-18, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa48946
Ahmad, S., Joseph, L., Parker, J., Asadzadeh, M., Kelly, S., Meis, J., & Khan, Z. (2018). ERG6 and ERG2 Are Major Targets Conferring Reduced Susceptibility to Amphotericin B in Clinical Candida glabrata Isolates in Kuwait. Antimicrobial Agents and Chemotherapy, 63(2), e01900-18
https://doi.org/10.1128/AAC.01900-18, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa45903
Zhou, W., Warrilow, A., Thomas, C., Ramos, E., Parker, J., Price, C., Vanderloop, B., Fisher, P., Loftis, M., Kelly, D., Kelly, S., & Nes, W. (2018). Functional importance for developmental regulation of sterol biosynthesis in Acanthamoeba castellanii. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 1863(10), 1164-1178.
https://doi.org/10.1016/j.bbalip.2018.07.004, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa41148
Luna-Tapia, A., Willems, H., Parker, J., Tournu, H., Barker, K., Nishimoto, A., Rogers, P., Kelly, S., Peters, B., & Palmer, G. (2018). Loss of Upc2p-Inducible ERG3 Transcription Is Sufficient To Confer Niche-Specific Azole Resistance without Compromising Candida albicans Pathogenicity. mBio, 9(3), e00225-18
https://doi.org/10.1128/mBio.00225-18, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa40336
Colley, T., Sehra, G., Chowdhary, A., Alanio, A., Kelly, S., Kizawa, Y., Armstrong-James, D., Fisher, M., Warrilow, A., Parker, J., Kelly, D., Kimura, G., Nishimoto, Y., Sunose, M., Onions, S., Crepin, D., Lagasse, F., Crittall, M., Shannon, J...., & Rapeport, G. (2018). In Vitro and In Vivo Efficacy of a Novel and Long-Acting Fungicidal Azole, PC1244, on Aspergillus fumigatus Infection. Antimicrobial Agents and Chemotherapy, 62(5), AAC.01941-17
https://doi.org/10.1128/aac.01941-17, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa38876
http://dx.doi.org/10.1128/aac.01941-17
Butts, A., DeJarnette, C., Peters, T., Parker, J., Kerns, M., Eberle, K., Kelly, S., & Palmer, G. (2017). Target Abundance-Based Fitness Screening (TAFiS) Facilitates Rapid Identification of Target-Specific and Physiologically Active Chemical Probes. mSphere, 2(5), e00379-17
https://doi.org/10.1128/mSphere.00379-17, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa36657
Rybak, J., Dickens, C., Parker, J., Caudle, K., Manigaba, K., Whaley, S., Nishimoto, A., Luna-Tapia, A., Roy, S., Zhang, Q., Barker, K., Palmer, G., Sutter, T., Homayouni, R., Wiederhold, N., Kelly, S., & Rogers, P. (2017). Loss of C-5 Sterol Desaturase Activity Results in Increased Resistance to Azole and Echinocandin Antifungals in a Clinical Isolate of Candida parapsilosis. Antimicrobial Agents and Chemotherapy, 61(9), AAC.00651-17
https://doi.org/10.1128/aac.00651-17, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa34548
http://dx.doi.org/10.1128/aac.00651-17
Warrilow, A., Parker, J., Price, C., Garvey, E., Hoekstra, W., Schotzinger, R., Wiederhold, N., Nes, W., Kelly, D., & Kelly, S. (2017). The Tetrazole VT-1161 Is a Potent Inhibitor of Trichophyton rubrum through Its Inhibition of T. rubrum CYP51. Antimicrobial Agents and Chemotherapy, 61(7), e00333-17
https://doi.org/10.1128/AAC.00333-17, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa34176
Colley, T., Alanio, A., Kelly, S., Sehra, G., Kizawa, Y., Warrilow, A., Parker, J., Kelly, D., Kimura, G., Anderson-Dring, L., Nakaoki, T., Sunose, M., Onions, S., Crepin, D., Lagasse, F., Crittall, M., Shannon, J., Cooke, M., Bretagne, S...., & Rapeport, G. (2017). In vitro and in vivo antifungal profile of a novel and long acting inhaled azole, PC945, on Aspergillus fumigatus infection. Antimicrobial Agents and Chemotherapy, AAC.02280-16
https://doi.org/10.1128/AAC.02280-16, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32189
Warrilow, A., Price, C., Parker, J., Rolley, N., Smyrniotis, C., Hughes, D., Thoss, V., Nes, W., Kelly, D., Holman, T., & Kelly, S. (2016). Azole Antifungal Sensitivity of Sterol 14α-Demethylase (CYP51) and CYP5218 from Malassezia globosa. Scientific Reports, 6(1)
https://doi.org/10.1038/srep27690, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa34335
McCourt, P., Liu, H., Parker, J., Gallo-Ebert, C., Donigan, M., Bata, A., Giordano, C., Kelly, S., Nickels, J., & Parker, J. (2016). Proper Sterol Distribution Is Required for Candida albicans Hyphal Formation and Virulence. G3 Genes|Genomes|Genetics, 6(11)
https://doi.org/10.1534/g3.116.033969, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa31346
Warrilow, A., Parker, J., Price, C., Nes, W., Garvey, E., Hoekstra, W., Schotzinger, R., Kelly, D., & Kelly, S. (2016). The Investigational Drug VT-1129 Is a Highly Potent Inhibitor of Cryptococcus Species CYP51 but Only Weakly Inhibits the Human Enzyme. Antimicrobial Agents and Chemotherapy, 60(8), 4530-4538.
https://doi.org/10.1128/AAC.00349-16, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa29154
Derbyshire, M., Michaelson, L., Parker, J., Kelly, S., Thacker, U., Powers, S., Bailey, A., Hammond-Kosack, K., Courbot, M., & Rudd, J. (2015). Analysis of cytochrome b5 reductase-mediated metabolism in the phytopathogenic fungus Zymoseptoria tritici reveals novel functionalities implicated in virulence. Fungal Genetics and Biology
https://doi.org/10.1016/j.fgb.2015.05.008, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa22091
Price, C., Parker, J., Warrilow, A., Kelly, D., & Kelly, S. (2015). Azole fungicides - understanding resistance mechanisms in agricultural fungal pathogens. Pest Management Science, n/a-n/a.
https://doi.org/10.1002/ps.4029, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa20922
Warrilow, A., Parker, J., Price, C., Nes, W., Kelly, S., & Kelly, D. (2015). In Vitro Biochemical Study of CYP51-Mediated Azole Resistance in Aspergillus fumigatus. Antimicrobial Agents and Chemotherapy, 59(12), 7771-7778.
https://doi.org/10.1128/aac.01806-15, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa23614
http://dx.doi.org/10.1128/aac.01806-15
Berkow, E., Manigaba, K., Parker, J., Barker, K., Kelly, S., & Rogers, P. (2015). Multidrug Transporters and Alterations in Sterol Biosynthesis Contribute to Azole Antifungal Resistance in Candida parapsilosis. Antimicrobial Agents and Chemotherapy, 59(10), 5942-5950.
https://doi.org/10.1128/aac.01358-15, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa22523
http://dx.doi.org/10.1128/aac.01358-15
Lamb, D., Warrilow, A., Rolley, N., Parker, J., Nes, W., Smith, S., Kelly, D., & Kelly, S. (2015). Azole Antifungal Agents To Treat the Human Pathogens Acanthamoeba castellanii and Acanthamoeba polyphaga through Inhibition of Sterol 14α-Demethylase (CYP51). Antimicrobial Agents and Chemotherapy, 59(8), 4707-4713.
https://doi.org/10.1128/AAC.00476-15, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa31514
http://aac.asm.org/content/59/8/4707.full.pdf+html
Price, C., Warrilow, A., Parker, J., Mullins, J., Nes, W., Kelly, D., Kelly, S., & Schottel, J. (2015). Novel Substrate Specificity and Temperature-Sensitive Activity of Mycosphaerella graminicola CYP51 Supported by the Native NADPH Cytochrome P450 Reductase. Applied and Environmental Microbiology, 81(10), 3379-3386.
https://doi.org/10.1128/AEM.03965-14, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa20704
Parker, J., Warrilow, A., Price, C., Mullins, J., Kelly, D., & Kelly, S. (2014). Resistance to antifungals that target CYP51. Journal of Chemical Biology, 7(4), 143-161.
https://doi.org/10.1007/s12154-014-0121-1, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa18694
Warrilow, A., Hull, C., Rolley, N., Parker, J., Nes, W., Smith, S., Kelly, D., & Kelly, S. (2014). Clotrimazole as a Potent Agent for Treating the Oomycete Fish Pathogen Saprolegnia parasitica through Inhibition of Sterol 14 -Demethylase (CYP51). Applied and Environmental Microbiology, 80(19), 6154-6166.
https://doi.org/10.1128/AEM.01195-14, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa18616
Warrilow, A., Hull, C., Parker, J., Garvey, E., Hoekstra, W., Moore, W., Schotzinger, R., Kelly, D., Kelly, S., & Hull, C. (2014). The Clinical Candidate VT-1161 Is a Highly Potent Inhibitor of Candida albicans CYP51 but Fails To Bind the Human Enzyme. Antimicrobial Agents and Chemotherapy, 58(12), 7121-7127.
https://doi.org/10.1128/AAC.03707-14, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa18693
Fan, J., Urban, M., Parker, J., Brewer, H., Kelly, S., Hammond-Kosack, K., Fraaije, B., Liu, X., & Cools, H. (2013). Characterization of the sterol 14α-demethylases of Fusarium graminearum identifies a novel genus-specific CYP51 function. New Phytologist-n/a.
https://doi.org/10.1111/NPH.12193, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa14421
Eddouzi, J., Parker, J., Vale-Silva, L., Coste, A., Ischer, F., Kelly, S., Manai, M., & Sanglard, D. (2013). Molecular Mechanisms of Drug Resistance in Clinical Candida Species Isolated from Tunisian Hospitals. Antimicrobial Agents and Chemotherapy, 57(7), 3182-3193.
https://doi.org/10.1128/AAC.00555-13, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa15187
Nie, D., Hoobler, E., Rai, G., Warrilow, A., Perry, S., Smyrniotis, C., Jadhav, A., Simeonov, A., Parker, J., Kelly, D., Maloney, D., Kelly, S., & Holman, T. (2013). Discovery of a Novel Dual Fungal CYP51/Human 5-Lipoxygenase Inhibitor: Implications for Anti-Fungal Therapy. PLoS ONE, 8(6)
https://doi.org/10.1371/journal.pone.0065928, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa15178
Kelly, S., Kelly, D., Parker, J., & Warrilow, A. (2013). Azole Affinity of Sterol 14alpha-Demethylase (CYP51) Enzymes from Candida albicans and Homo sapiens. Antimicrobial Agents and Chemotherapy, 57(3)-1360.
https://doi.org/10.1128/AAC.02067-12, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa14415
Hull, C., Bader, O., Parker, J., Weig, M., Gross, U., Warrilow, A., Kelly, D., & Kelly, S. (2012). Two Clinical Isolates of Candida glabrata Exhibiting Reduced Sensitivity to Amphotericin B Both Harbor Mutations inERG2. Antimicrobial Agents and Chemotherapy, 56(12), 6417-6421.
https://doi.org/10.1128/aac.01145-12, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa13028
http://dx.doi.org/10.1128/aac.01145-12
Hull, C., Parker, J., Bader, O., Weig, M., Gross, U., Warrilow, A., Kelly, D., & Kelly, S. (2012). Facultative Sterol Uptake in an Ergosterol-Deficient Clinical Isolate of Candida glabrata Harboring a Missense Mutation inERG11and Exhibiting Cross-Resistance to Azoles and Amphotericin B. Antimicrobial Agents and Chemotherapy, 56(8), 4223-4232.
https://doi.org/10.1128/aac.06253-11, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa12338
http://dx.doi.org/10.1128/aac.06253-11
Vale-Silva, L., Coste, A., Ischer, F., Parker, J., Kelly, S., Pinto, E., & Sanglard, D. (2012). Azole Resistance by Loss of Function of the Sterol Δ5,6-Desaturase Gene (ERG3) in Candida albicans Does Not Necessarily Decrease Virulence. Antimicrobial Agents and Chemotherapy, 56(4), 1960-1968.
https://doi.org/10.1128/aac.05720-11, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa6836
Mullins, J., Parker, J., Cools, H., Togawa, R., Lucas, J., Fraaije, B., Kelly, D., & Kelly, S. (2011). Molecular Modelling of the Emergence of Azole Resistance in Mycosphaerella graminicola. PLoS ONE, 6(6), e20973
https://doi.org/10.1371/journal.pone.0020973, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa6839
Cools, H., Mullins, J., Fraaije, B., Parker, J., Kelly, D., Lucas, J., & Kelly, S. (2011). Impact of Recently Emerged Sterol 14 alpha-Demethylase (CYP51) Variants of Mycosphaerella graminicola on Azole Fungicide Sensitivity. Applied and Environmental Microbiology, 77(11), 3830-3837.
https://doi.org/10.1128/AEM.00027-11, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa6846
Martel, C., Parker, J., Jackson, C., Warrilow, A., Rolley, N., Greig, C., Morris, S., Donnison, I., Kelly, D., Kelly, S., & Hull, C. (2011). Expression of bacterial levanase in yeast enables simultaneous saccharification and fermentation of grass juice to bioethanol. Bioresource Technology, 102(2), 1503-1508.
https://doi.org/10.1016/j.biortech.2010.07.099, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa6360
Warrilow, A., Melo, N., Martel, C., Parker, J., Nes, W., Kelly, S., & Kelly, D. (2010). Expression, Purification, and Characterization of Aspergillus fumigatus Sterol 14alpha-Demethylase (CYP51) Isoenzymes A and B. Antimicrobial Agents and Chemotherapy, 54(10), 4225-4234.
https://doi.org/10.1128/AAC.00316-10, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa6354
Martel, C., Parker, J., Bader, O., Weig, M., Gross, U., Warrilow, A., Kelly, D., Kelly, S., Parker, J., & Hull, C. (2010). A Clinical Isolate of Candida albicans with Mutations in ERG11 (Encoding Sterol 14alpha-Demethylase) and ERG5 (Encoding C22 Desaturase) Is Cross Resistant to Azoles and Amphotericin B. Antimicrobial Agents and Chemotherapy, 54(9), 3578-3583.
https://doi.org/10.1128/AAC.00303-10, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa6353
Warrilow, A., Martel, C., Parker, J., Melo, N., Lamb, D., Nes, W., Kelly, D., Kelly, S., & Hull, C. (2010). Azole Binding Properties of Candida albicans Sterol 14alpha-Demethylase (CaCYP51). Antimicrobial Agents and Chemotherapy, 54(10), 4235-4245.
https://doi.org/10.1128/AAC.00587-10, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa6355
Martel, C., Parker, J., Warrilow, A., Rolley, N., Kelly, S., Kelly, D., Parker, J., Hull, C., & Warrilow, A. (2010). Complementation of a Saccharomyces cerevisiae ERG11/CYP51 (Sterol 14alpha-Demethylase) Doxycycline-Regulated Mutant and Screening of the Azole Sensitivity of Aspergillus fumigatus Isoenzymes CYP51A and CYP51B. Antimicrobial Agents and Chemotherapy, 54(11), 4920-4923.
https://doi.org/10.1128/AAC.00349-10, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa6356
Martel, C., Warrilow, A., Jackson, C., Mullins, J., Togawa, R., Parker, J., Morris, M., Donnison, I., Kelly, D., Kelly, S., Mullins, J., & Hull, C. (2010). Expression, purification and use of the soluble domain of Lactobacillus paracasei β-fructosidase to optimise production of bioethanol from grass fructans. Bioresource Technology, 101(12), 4395-4402.
https://doi.org/10.1016/j.biortech.2010.01.084, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa6359
Parker, J., Warrilow, A., Cools, H., Martel, C., Nes, W., Fraaije, B., Lucas, J., Kelly, D., Kelly, S., & Hull, C. (2010). Mechanism of Binding of Prothioconazole to Mycosphaerella graminicola CYP51 Differs from That of Other Azole Antifungals. Applied and Environmental Microbiology, 77(4), 1460-1465.
https://doi.org/10.1128/AEM.01332-10, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa6361
Martel, C., Parker, J., Bader, O., Weig, M., Gross, U., Warrilow, A., Rolley, N., Kelly, D., Kelly, S., & Hull, C. (2010). Identification and Characterization of Four Azole-Resistant erg3 Mutants of Candida albicans. Antimicrobial Agents and Chemotherapy, 54(11), 4527-4533.
https://doi.org/10.1128/AAC.00348-10, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa6358
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https://doi.org/10.1128/aem.02158-09, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa6856
http://dx.doi.org/10.1128/aem.02158-09
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https://doi.org/10.1128/AAC.00517-08, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa6835
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Modiwlau a Addysgir

PM-250C Clefydau heintus

Bydd y cwrs yn adeiladu ar sylfeini microbioleg ac yn cyflwyno pynciau newydd ym meysydd bacterioleg, mycoleg, firoleg a pharasitoleg. Mae Imiwnoleg Lefel 5 (PM-249) yn rhagofyniad. Mae'r cwrs yn ymdrin ag egwyddorion sylfaenol clefydau heintus, gan gynnwys agweddau clinigol, triniaeth/atal, ac ymagweddau arbrofol at astudio organebau heintus a pharasitig.
PMGM21 Pharmacogenomics & Stratified Healthcare

Pharmacogenomics and stratified health care ensure that healthcare professionals offer the right treatment, for the right person, at the right time is a fast-developing area. `Personalised medicine¿ is the buzzword of the moment, with advances in pharmacogenomic testing enabling more effective, targeted therapies to patients in the field of asthma, analgesia, oncology and beyond. Continued understanding of the genomic basis of drug response will reduce drug-related adverse effects, save costs, and ensure a better therapeutic outcome. This module will provide a comprehensive overview of the analytical strategies and techniques used in pharmacogenomics and explore some of the challenges and limitations in this field. The module will also provide an overview of the different type of pharmacogenomic biomarkers currently in use or emerging and the current feasibility of delivering `personalised medicine¿ in the clinic.