Dr Kirsty Meldrum

Swyddog Ymchwil

Biomedical Sciences

+44 (0) 1792 205678 ext 1263

kirsty.meldrum@abertawe.ac.uk

Ar gael ar gyfer Goruchwyliaeth Ôl-raddedig

Dolenni Ymchwil

Scopus

Trosolwg

Enillodd Kirsty ei PhD yng Ngholeg Imperial Llundain a Public Health England drwy ganfod effeithiau nanoronynnau o ceriwm deuocsid a gronynnau egsôst diesel ar fodelau in vitro ac in vivo o glefyd y llwybr anadlu.

Ar ôl iddi ennill ei PhD, gweithiodd Kirsty yng Ngrŵp Tocsicoleg In Vitro Prifysgol Abertawe lle y bu'n cyfrannu at ymchwil y rhaglen a ariennir gan Horizon 2020: PATROLS (Physiologically Anchored Tools for Realistic nanOmateriaL hazard aSsessment). Canolbwyntio'n benodol ar ddatblygu modelau uwch in vitro o'r ysgyfaint a'u rhoi ar waith i brofi tocsicoleg nanoddeunyddiau.

Mae Kirsty yn gweithio ar hyn o bryd fel Swyddog Ymchwil ar gyfer prosiect RESPIRE - sydd wedi'i ariannu gan y Sefydliad Cenedlaethol dros Ymchwil Iechyd a Gofal ac Ymchwil ac Arloesi yn y DU (UKRI) trwy eu rhaglen Blaenoriaethau Strategol: Ariannu Aer Glân. Nod y prosiect hwn yw asesu'r effaith o ddod i gysylltiad â llygredd aer (dan do ac yn yr awyr agored) yn ystod beichiogrwydd ar ddatblygiad ac iechyd plant. Mae Kirsty yn canolbwyntio ar y llwybrau anadlu a defnyddio dulliau uwch o astudio dod i gysylltiad â chydrannau llygredd amrywiol.

Meysydd Arbenigedd

Nanowenwyneg
Nodweddu Nanoronynnau
Modelau o'r llwybr anadlu
Llygredd Aer
Rhyngweithiadau rhwng Celloedd Nanoronynnau
Tocsicoleg
Ymagweddau Uwch at Astudio Cysylltiadau in vitro

Cyhoeddiadau

Uchafbwyntiau Ymchwil

Barosova, H., Meldrum, K., Karakocak, B., Balog, S., Doak, S., Petri-Fink, A., Clift, M., & Rothen-Rutishauser, B. (2021). Inter-laboratory variability of A549 epithelial cells grown under submerged and air-liquid interface conditions. Toxicology in Vitro, 75, 105178
https://doi.org/10.1016/j.tiv.2021.105178, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56826
Meldrum, K., Evans, S., Vogel, U., Tran, L., Doak, S., & Clift, M. (2022). The influence of exposure approaches to in vitro lung epithelial barrier models to assess engineered nanomaterial hazard. Nanotoxicology, 16(1), 114-134.
https://doi.org/10.1080/17435390.2022.2051627, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa59667
Evans, S., Lawrence, R., Ilett, M., Burgum, M., Meldrum, K., Hondow, N., Jenkins, G., Clift, M., & Doak, S. (2022). Industrial-relevant TiO2 types do not promote cytotoxicity in the A549 or TK6 cell lines regardless of cell specific interaction. Toxicology in Vitro, 83, 105415
https://doi.org/10.1016/j.tiv.2022.105415, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa60312
Meldrum, K., Amaral Duarte De Moura, J., Doak, S., & Clift, M. (2022). Dynamic Fluid Flow Exacerbates the (Pro-)Inflammatory Effects of Aerosolised Engineered Nanomaterials In Vitro. Nanomaterials, 12(19), 3431
https://doi.org/10.3390/nano12193431, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61384
Bannuscher, A., Schmid, O., Drasler, B., Rohrbasser, A., Braakhuis, H., Meldrum, K., Zwart, E., Gremmer, E., Birk, B., Rissel, M., Landsiedel, R., Moschini, E., Evans, S., Kumar, P., Orak, S., Doryab, A., Erdem, J., Serchi, T., Vandebriel, R...., & Rothen-Rutishauser, B. (2022). An inter-laboratory effort to harmonize the cell-delivered in vitro dose of aerosolized materials. NanoImpact, 28, 100439
https://doi.org/10.1016/j.impact.2022.100439, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa62077
Amaral Duarte De Moura, J., Meldrum, K., Doak, S., & Clift, M. (2023). Alternative lung cell model systems for toxicology testing strategies: Current knowledge and future outlook. Seminars in Cell & Developmental Biology, 147, 70-82.
https://doi.org/10.1016/j.semcdb.2022.12.006, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa62217
http://dx.doi.org/10.1016/j.semcdb.2022.12.006
Braakhuis, H., Gremmer, E., Bannuscher, A., Drasler, B., Keshavan, S., Rothen-Rutishauser, B., Birk, B., Verlohner, A., Landsiedel, R., Meldrum, K., Doak, S., Clift, M., Erdem, J., Foss, O., Zienolddiny-Narui, S., Serchi, T., Moschini, E., Weber, P., Burla, S...., & Vandebriel, R. (2023). Transferability and reproducibility of exposed air-liquid interface co-culture lung models. NanoImpact, 31, 100466
https://doi.org/10.1016/j.impact.2023.100466, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa63446
http://dx.doi.org/10.1016/j.impact.2023.100466
Meldrum, K., Evans, S., Burgum, M., Doak, S., & Clift, M. (2024). Determining the toxicological effects of indoor air pollution on both a healthy and an inflammatory-comprised model of the alveolar epithelial barrier in vitro. Particle and Fibre Toxicology, 21(1)
https://doi.org/10.1186/s12989-024-00584-8, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa66993
Mitchell, S., Meldrum, K., Bateman, J., Tetley, T., Doak, S., & Clift, M. (2024). Development and characterisation of a novel complex triple cell culture model of the human alveolar epithelial barrier. In vitro models, 3(2-3), 125-137.
https://doi.org/10.1007/s44164-024-00075-2, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa67177
Wilkinson, R., Meldrum, K., MAGGS, C., Thomas, N., Thomas, B., De Mello, N., & Joyce, N. (2023). Determining the efficacy of disinfectants at nucleic acid degradation. Journal of Applied Microbiology, 134(11)
https://doi.org/10.1093/jambio/lxad244, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa67706

Holl Ymchwil

Erthyglau Cylchgronau

Mitchell, S., Meldrum, K., Bateman, J., Tetley, T., Doak, S., & Clift, M. (2024). Development and characterisation of a novel complex triple cell culture model of the human alveolar epithelial barrier. In vitro models, 3(2-3), 125-137.
https://doi.org/10.1007/s44164-024-00075-2, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa67177
Meldrum, K., Evans, S., Burgum, M., Doak, S., & Clift, M. (2024). Determining the toxicological effects of indoor air pollution on both a healthy and an inflammatory-comprised model of the alveolar epithelial barrier in vitro. Particle and Fibre Toxicology, 21(1)
https://doi.org/10.1186/s12989-024-00584-8, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa66993
Wilkinson, R., Meldrum, K., MAGGS, C., Thomas, N., Thomas, B., De Mello, N., & Joyce, N. (2023). Determining the efficacy of disinfectants at nucleic acid degradation. Journal of Applied Microbiology, 134(11)
https://doi.org/10.1093/jambio/lxad244, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa67706
Amaral Duarte De Moura, J., Meldrum, K., Doak, S., & Clift, M. (2023). Alternative lung cell model systems for toxicology testing strategies: Current knowledge and future outlook. Seminars in Cell & Developmental Biology, 147, 70-82.
https://doi.org/10.1016/j.semcdb.2022.12.006, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa62217
http://dx.doi.org/10.1016/j.semcdb.2022.12.006
Braakhuis, H., Gremmer, E., Bannuscher, A., Drasler, B., Keshavan, S., Rothen-Rutishauser, B., Birk, B., Verlohner, A., Landsiedel, R., Meldrum, K., Doak, S., Clift, M., Erdem, J., Foss, O., Zienolddiny-Narui, S., Serchi, T., Moschini, E., Weber, P., Burla, S...., & Vandebriel, R. (2023). Transferability and reproducibility of exposed air-liquid interface co-culture lung models. NanoImpact, 31, 100466
https://doi.org/10.1016/j.impact.2023.100466, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa63446
http://dx.doi.org/10.1016/j.impact.2023.100466
Bannuscher, A., Schmid, O., Drasler, B., Rohrbasser, A., Braakhuis, H., Meldrum, K., Zwart, E., Gremmer, E., Birk, B., Rissel, M., Landsiedel, R., Moschini, E., Evans, S., Kumar, P., Orak, S., Doryab, A., Erdem, J., Serchi, T., Vandebriel, R...., & Rothen-Rutishauser, B. (2022). An inter-laboratory effort to harmonize the cell-delivered in vitro dose of aerosolized materials. NanoImpact, 28, 100439
https://doi.org/10.1016/j.impact.2022.100439, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa62077
Meldrum, K., Amaral Duarte De Moura, J., Doak, S., & Clift, M. (2022). Dynamic Fluid Flow Exacerbates the (Pro-)Inflammatory Effects of Aerosolised Engineered Nanomaterials In Vitro. Nanomaterials, 12(19), 3431
https://doi.org/10.3390/nano12193431, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61384
Evans, S., Lawrence, R., Ilett, M., Burgum, M., Meldrum, K., Hondow, N., Jenkins, G., Clift, M., & Doak, S. (2022). Industrial-relevant TiO2 types do not promote cytotoxicity in the A549 or TK6 cell lines regardless of cell specific interaction. Toxicology in Vitro, 83, 105415
https://doi.org/10.1016/j.tiv.2022.105415, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa60312
Meldrum, K., Evans, S., Vogel, U., Tran, L., Doak, S., & Clift, M. (2022). The influence of exposure approaches to in vitro lung epithelial barrier models to assess engineered nanomaterial hazard. Nanotoxicology, 16(1), 114-134.
https://doi.org/10.1080/17435390.2022.2051627, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa59667
Barosova, H., Meldrum, K., Karakocak, B., Balog, S., Doak, S., Petri-Fink, A., Clift, M., & Rothen-Rutishauser, B. (2021). Inter-laboratory variability of A549 epithelial cells grown under submerged and air-liquid interface conditions. Toxicology in Vitro, 75, 105178
https://doi.org/10.1016/j.tiv.2021.105178, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56826

Modiwlau a Addysgir

PM-130 Fundamental Research Skills

This module is designed to develop the skills required for students of biochemistry and genetics degree programmes. Students meet with their tutors and will be given a series of assignments designed to develop skills in key areas such as essay writing, presentations and general numeracy.
PM-351 Nanotoxicology

Nanomaterials are comprised of very small particles that provide many of the products we use increased strength, chemical reactivity or conductivity. They can also be the by-product of e.g. industrial processes or they can occur naturally, as with soot from forest fires or volcanic ash. The particles range in size from approximately 1 to 100 nanometres; that is 1 / 1,000,000,000th of a metre. Due to their small size they can readily enter our bodies through a number of exposure routes, of which inhalation, ingestion or absorption through the skin, as well as injection into the circulation are dominant. These particles have unique properties compared to their larger counterparts and we are only beginning to understand what their health effects may be. The purpose of this module is to give an introduction into the field of nanoscience, nanotechnology and the potential risks posed by this new Industrial Age to humans.
PM-M28 Nano(geno)toxicology

The field of nanotechnology is ever increasing in size, and the number of nano-sized (1-100nm) particles being produced on a daily basis is at the tonnage level. Although nanotechnology-based applications are considered to be advantageous for a plethora of human activities, the potential risks posed by human exposure to nanoparticles is a constantly developing field of research. The purpose of this module therefore is to introduce to the student to particle toxicology and how it can impact upon human health. Further to this, the students will undertake a specific practical component to complement that of the theoretical content of the module. To this extent, the students will undertake a week-long, 'mini-project', covering the major areas of nanoparticle toxicology. From this approach, it is intended that the student will experience the key practical approaches taken in the field.

Dr Kirsty Meldrum

Rhif ffôn

Cyfeiriad ebost