Dr Marcella Bassetto

Uwch-ddarlithydd Er Anrhydedd

Faculty of Science and Engineering

marcella.bassetto@abertawe.ac.uk

Ar gael ar gyfer Goruchwyliaeth Ôl-raddedig

Dolenni Ymchwil

Trosolwg

Graddiais mewn Cemeg a Thechnoleg Feddyginiaethol ym Mhrifysgol Padova, yr Eidal, yn 2010, a chefais fy PhD mewn Cemeg Feddygol o Brifysgol Caerdydd yn 2013, gan weithio ar gynllunio drwy gymorth cyfrifiadur a synthesis cyfryngau gwrthfeirysol posib newydd yn erbyn HCV. Ar ôl fy astudiaethau PhD, gweithiais fel Cydymaith Ymchwil Ôl-ddoethurol ym Mhrifysgol Caerdydd am flwyddyn, gan ddatblygu cyfryngau gwrthganser fflworinedig newydd i drin canser y prostad. Ar ôl hynny ymunais â chwmni fferyllol yn Rhufain am gyfnod byr i weithio fel cemegydd synthetig yn datblygu cyffuriau newydd. Yna dychwelais i Brifysgol Caerdydd i ailafael yn fy ngwaith ymchwil academaidd ar ddylunio gyda chymorth cyfrifiadur a synthesis cyffuriau posib newydd, ac yn 2016 dyfarnwyd Cymrodoriaeth Ymchwil Unigol Sêr Cymru II i mi, lle bues i’n canolbwyntio ar ddylunio in silico a synthesis cyfryngau gwrthfeirysol newydd. Ym mis Medi 2019, cefais fy mhenodi’n Ddarlithydd Cemeg ym Mhrifysgol Abertawe. Rwy’n Llysgennad STEM ers 2016.

Meysydd Arbenigedd

Modelu moleciwlaidd
Cynllunio cyffuriau drwy gymorth cyfrifiadur
Cemeg meddyginiaethol
Cemeg organig synthetig

Cyhoeddiadau

Uchafbwyntiau Ymchwil

Salerno, M., Varricchio, C., Bevilacqua, F., Jochmans, D., Neyts, J., Brancale, A., Ferla, S., & Bassetto, M. (2023). Rational design of novel nucleoside analogues reveals potent antiviral agents for EV71. European Journal of Medicinal Chemistry, 246, 114942
https://doi.org/10.1016/j.ejmech.2022.114942, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa62048
Picarazzi, F., Zuanon, M., Pasqualetto, G., Cammarone, S., Romeo, I., Young, M., Brancale, A., Bassetto, M., & Mori, M. (2022). Identification of Small Molecular Chaperones Binding P23H Mutant Opsin through an In Silico Structure-Based Approach. Journal of Chemical Information and Modeling, 62(22), 5794-5805.
https://doi.org/10.1021/acs.jcim.2c01040, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa62042
Menendez-Gonzalez, J., Strange, K., Bassetto, M., Brancale, A., Rodrigues, N., & Ferla, S. (2022). Ligand-based discovery of a novel GATA2 inhibitor targeting acute myeloid leukemia cells. Frontiers in Drug Discovery, 2
https://doi.org/10.3389/fddsv.2022.1013229, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61795
Hucke, F., Bestehorn-Willmann, M., Bassetto, M., Brancale, A., Zanetta, P., & Bugert, J. (2022). CHIKV strains Brazil (wt) and Ross (lab-adapted) differ with regard to cell host range and antiviral sensitivity and show CPE in human glioblastoma cell lines U138 and U251. Virus Genes, 58(3), 188-202.
https://doi.org/10.1007/s11262-022-01892-x, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa60170
Schepelmann, M., Kupper, N., Sladczyk, M., Mansfield, B., Manhardt, T., Piatek, K., Iamartino, L., Riccardi, D., Kariuki, B., Bassetto, M., & Kallay, E. (2021). Stereo-Specific Modulation of the Extracellular Calcium-Sensing Receptor in Colon Cancer Cells. International Journal of Molecular Sciences, 22(18), 10124
https://doi.org/10.3390/ijms221810124, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa58160
Queirós-Reis, L., Silva, P., Gonçalves, J., Brancale, A., Bassetto, M., & Mesquita, J. (2021). SARS-CoV-2 Virus−Host Interaction: Currently Available Structures and Implications of Variant Emergence on Infectivity and Immune Response. International Journal of Molecular Sciences, 22(19), 10836
https://doi.org/10.3390/ijms221910836, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa58363
Bassetto, M. & Brancale, A. (2021). The search for antivirals to treat alphavirus infections. Annual Reports in Medicinal Chemistry (pp. 133-151). Elsevier
https://doi.org/10.1016/bs.armc.2021.09.002, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa58368
Gill, M., Jarman, P., Hearnden, V., Fairbanks, S., Bassetto, M., Maib, H., Palmer, J., Ayscough, K., Thomas, J., & Smythe, C. (2022). A Ruthenium(II) Polypyridyl Complex Disrupts Actin Cytoskeleton Assembly and Blocks Cytokinesis. Angewandte Chemie International Edition, 61(27), e202117449
https://doi.org/10.1002/anie.202117449, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa59895
Pasqualetto, G., Pileggi, E., Schepelmann, M., Varricchio, C., Rozanowska, M., Brancale, A., & Bassetto, M. (2021). Ligand-based rational design, synthesis and evaluation of novel potential chemical chaperones for opsin. European Journal of Medicinal Chemistry, 226, 113841
https://doi.org/10.1016/j.ejmech.2021.113841, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa57962
Nannetti, G., Flude, B., Nannetti, G., Mitchell, P., Compton, N., Richards, C., Heurich, M., Brancale, A., Ferla, S., & Bassetto, M. (2021). Targeting the Complement Serine Protease MASP-2 as a Therapeutic Strategy for Coronavirus Infections. Viruses, 13(2), 312
https://doi.org/10.3390/v13020312, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56279

Holl Ymchwil

Erthyglau Cylchgronau

Salerno, M., Varricchio, C., Bevilacqua, F., Jochmans, D., Neyts, J., Brancale, A., Ferla, S., & Bassetto, M. (2023). Rational design of novel nucleoside analogues reveals potent antiviral agents for EV71. European Journal of Medicinal Chemistry, 246, 114942
https://doi.org/10.1016/j.ejmech.2022.114942, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa62048
Padalino, G., Giancotti, G., Nannetti, G., Padalino, G., Landini, M., Santos-Ferreira, N., Dycke, J., Naccarato, V., Patel, U., Silvestri, R., Neyts, J., Gozalbo-Rovira, R., Rodríguez-Díaz, J., Rocha-Pereira, J., Brancale, A., Ferla, S., & Bassetto, M. (2022). Structural Investigations on Novel Non-Nucleoside Inhibitors of Human Norovirus Polymerase. Viruses, 15(1), 74
https://doi.org/10.3390/v15010074, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa62577
Picarazzi, F., Zuanon, M., Pasqualetto, G., Cammarone, S., Romeo, I., Young, M., Brancale, A., Bassetto, M., & Mori, M. (2022). Identification of Small Molecular Chaperones Binding P23H Mutant Opsin through an In Silico Structure-Based Approach. Journal of Chemical Information and Modeling, 62(22), 5794-5805.
https://doi.org/10.1021/acs.jcim.2c01040, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa62042
Menendez-Gonzalez, J., Strange, K., Bassetto, M., Brancale, A., Rodrigues, N., & Ferla, S. (2022). Ligand-based discovery of a novel GATA2 inhibitor targeting acute myeloid leukemia cells. Frontiers in Drug Discovery, 2
https://doi.org/10.3389/fddsv.2022.1013229, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61795
Gill, M., Jarman, P., Hearnden, V., Fairbanks, S., Bassetto, M., Maib, H., Palmer, J., Ayscough, K., Thomas, J., & Smythe, C. (2022). A Ruthenium(II) Polypyridyl Complex Disrupts Actin Cytoskeleton Assembly and Blocks Cytokinesis. Angewandte Chemie International Edition, 61(27), e202117449
https://doi.org/10.1002/anie.202117449, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa59895
Hucke, F., Bestehorn-Willmann, M., Bassetto, M., Brancale, A., Zanetta, P., & Bugert, J. (2022). CHIKV strains Brazil (wt) and Ross (lab-adapted) differ with regard to cell host range and antiviral sensitivity and show CPE in human glioblastoma cell lines U138 and U251. Virus Genes, 58(3), 188-202.
https://doi.org/10.1007/s11262-022-01892-x, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa60170
Pasqualetto, G., Pileggi, E., Schepelmann, M., Varricchio, C., Rozanowska, M., Brancale, A., & Bassetto, M. (2021). Ligand-based rational design, synthesis and evaluation of novel potential chemical chaperones for opsin. European Journal of Medicinal Chemistry, 226, 113841
https://doi.org/10.1016/j.ejmech.2021.113841, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa57962
Padalino, G., Padalino, G., El-Sakkary, N., Liu, L., Liu, C., Harte, D., Barnes, R., Sayers, E., Forde-Thomas, J., Whiteland, H., Bassetto, M., Ferla, S., Johnson, G., Jones, A., Caffrey, C., Chalmers, I., Brancale, A., & Hoffmann, K. (2021). Anti-schistosomal activities of quinoxaline-containing compounds: From hit identification to lead optimisation. European Journal of Medicinal Chemistry, 226, 113823
https://doi.org/10.1016/j.ejmech.2021.113823, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa57836
Queirós-Reis, L., Silva, P., Gonçalves, J., Brancale, A., Bassetto, M., & Mesquita, J. (2021). SARS-CoV-2 Virus−Host Interaction: Currently Available Structures and Implications of Variant Emergence on Infectivity and Immune Response. International Journal of Molecular Sciences, 22(19), 10836
https://doi.org/10.3390/ijms221910836, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa58363
Schepelmann, M., Kupper, N., Sladczyk, M., Mansfield, B., Manhardt, T., Piatek, K., Iamartino, L., Riccardi, D., Kariuki, B., Bassetto, M., & Kallay, E. (2021). Stereo-Specific Modulation of the Extracellular Calcium-Sensing Receptor in Colon Cancer Cells. International Journal of Molecular Sciences, 22(18), 10124
https://doi.org/10.3390/ijms221810124, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa58160
Ferla, S., Varricchio, C., Knight, W., Ho, P., Saporito, F., Tropea, B., Fagan, G., Flude, B., Bevilacqua, F., Santos-Ferreira, N., Dycke, J., Neyts, J., Brancale, A., Rocha-Pereira, J., & Bassetto, M. (2021). Structure–Activity Relationship Studies on Novel Antiviral Agents for Norovirus Infections. Microorganisms, 9(9), 1795
https://doi.org/10.3390/microorganisms9091795, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa57742
Nannetti, G., Flude, B., Nannetti, G., Mitchell, P., Compton, N., Richards, C., Heurich, M., Brancale, A., Ferla, S., & Bassetto, M. (2021). Targeting the Complement Serine Protease MASP-2 as a Therapeutic Strategy for Coronavirus Infections. Viruses, 13(2), 312
https://doi.org/10.3390/v13020312, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56279
Thames, J., Waters, C., Valle, C., Bassetto, M., Aouadi, W., Martin, B., Selisko, B., Falat, A., Coutard, B., Brancale, A., Canard, B., Decroly, E., & Seley-Radtke, K. (2020). Synthesis and biological evaluation of novel flexible nucleoside analogues that inhibit flavivirus replication in vitro. Bioorganic & Medicinal Chemistry, 28(22), 115713
https://doi.org/10.1016/j.bmc.2020.115713, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa55108
Bauer, L., Manganaro, R., Zonsics, B., Hurdiss, D., Zwaagstra, M., Donselaar, T., Welter, N., Kleef, R., Lopez, M., Bevilacqua, F., Raman, T., Ferla, S., Bassetto, M., Neyts, J., Strating, J., Westerink, R., Brancale, A., & Kuppeveld, F. (2020). Rational design of highly potent broad-spectrum enterovirus inhibitors targeting the nonstructural protein 2C. PLOS Biology, 18(11), e3000904
https://doi.org/10.1371/journal.pbio.3000904, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa55886
Fernández-García, Y., Horst, S., Bassetto, M., Brancale, A., Neyts, J., Rogolino, D., Sechi, M., Carcelli, M., Günther, S., & Rocha-Pereira, J. (2020). Diketo acids inhibit the cap-snatching endonuclease of several Bunyavirales. Antiviral Research, 183, 104947
https://doi.org/10.1016/j.antiviral.2020.104947, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa55337
Pasqualetto, G., Schepelmann, M., Varricchio, C., Pileggi, E., Khogali, C., Morgan, S., Boostrom, I., Rozanowska, M., Brancale, A., Ferla, S., & Bassetto, M. (2020). Computational Studies towards the Identification of Novel Rhodopsin-Binding Compounds as Chemical Chaperones for Misfolded Opsins. Molecules, 25(21), 4904
https://doi.org/10.3390/molecules25214904, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa55537
Bassetto, M., Cima, C., Basso, M., Salerno, M., Schwarze, F., Friese, D., Bugert, J., & Brancale, A. (2020). Novel Nucleoside Analogues as Effective Antiviral Agents for Zika Virus Infections. Molecules, 25(20), 4813
https://doi.org/10.3390/molecules25204813, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa55480
Horst, S., Fernandez-Garcia, Y., Bassetto, M., Günther, S., Brancale, A., Neyts, J., & Rocha-Pereira, J. (2020). Enhanced efficacy of endonuclease inhibitor baloxavir acid against orthobunyaviruses when used in combination with ribavirin. Journal of Antimicrobial Chemotherapy, 75(11)
https://doi.org/10.1093/jac/dkaa337, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa54967
Ferla, S., Ferla, S., Manganaro, R., Benato, S., Paulissen, J., Neyts, J., Jochmans, D., Brancale, A., & Bassetto, M. (2020). Rational modifications, synthesis and biological evaluation of new potential antivirals for RSV designed to target the M2-1 protein. Bioorganic & Medicinal Chemistry, 28(8), 115401
https://doi.org/10.1016/j.bmc.2020.115401, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa53723
Bugert, J., Hucke, F., Zanetta, P., Bassetto, M., & Brancale, A. (2020). Antivirals in medical biodefense. Virus Genes
https://doi.org/10.1007/s11262-020-01737-5, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa53800
Elajnaf, T., Iamartino, L., Mesteri, I., Müller, C., Bassetto, M., Manhardt, T., Baumgartner-Parzer, S., Kallay, E., & Schepelmann, M. (2019). Nutritional and Pharmacological Targeting of the Calcium-Sensing Receptor Influences Chemically Induced Colitis in Mice. Nutrients, 11(12), 3072
https://doi.org/10.3390/nu11123072, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa53035
Giancotti, G., Rigo, I., Pasqualetto, G., Young, M., Neyts, J., Rocha-Pereira, J., Brancale, A., Ferla, S., & Bassetto, M. (2019). A new antiviral scaffold for human norovirus identified with computer-aided approaches on the viral polymerase. Scientific Reports, 9(1)
https://doi.org/10.1038/s41598-019-54903-7, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa52974
Pertusati, F., Ferla, S., Bassetto, M., Brancale, A., Khandil, S., Westwell, A., & McGuigan, C. (2019). A new series of bicalutamide, enzalutamide and enobosarm derivatives carrying pentafluorosulfanyl (SF5) and pentafluoroethyl (C2F5) substituents: Improved antiproliferative agents against prostate cancer. European Journal of Medicinal Chemistry, 180, 1-14.
https://doi.org/10.1016/j.ejmech.2019.07.001, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa52218
http://orca.cf.ac.uk/124785/
Bassetto, M., Dycke, J., Neyts, J., Brancale, A., & Rocha-Pereira, J. (2019). Targeting the Viral Polymerase of Diarrhea-Causing Viruses as a Strategy to Develop a Single Broad-Spectrum Antiviral Therapy. Viruses, 11(2), 173
https://doi.org/10.3390/v11020173, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa52217
Bassetto, M. & Slusarczyk, M. (2019). Therapeutic use of fluorinated nucleosides – progress in patents. Pharmaceutical Patent Analyst, 7(6), 277-299.
https://doi.org/10.4155/ppa-2018-0028, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa52216
Giancotti, G., Cancellieri, M., Balboni, A., Giustiniano, M., Novellino, E., Delang, L., Neyts, J., Leyssen, P., Brancale, A., & Bassetto, M. (2018). Rational modifications on a benzylidene-acrylohydrazide antiviral scaffold, synthesis and evaluation of bioactivity against Chikungunya virus. European Journal of Medicinal Chemistry, 149, 56-68.
https://doi.org/10.1016/j.ejmech.2018.02.054, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa52214
Ferla, S., Netzler, N., Ferla, S., Veronese, S., Tuipulotu, D., Guccione, S., Brancale, A., White, P., & Bassetto, M. (2018). In silico screening for human norovirus antivirals reveals a novel non-nucleoside inhibitor of the viral polymerase. Scientific Reports, 8(1)
https://doi.org/10.1038/s41598-018-22303-y, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa52215
Tardugno, R., Giancotti, G., Burghgraeve, T., Delang, L., Neyts, J., Leyssen, P., Brancale, A., & Bassetto, M. (2018). Design, synthesis and evaluation against Chikungunya virus of novel small-molecule antiviral agents. Bioorganic & Medicinal Chemistry, 26(4), 869-874.
https://doi.org/10.1016/j.bmc.2018.01.002, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa52213
Bassetto, M., Ferla, S., Giancotti, G., Pertusati, F., Westwell, A., Brancale, A., & McGuigan, C. (2017). Rational design and synthesis of novel phenylsulfonyl-benzamides as anti-prostate cancer agents. MedChemComm, 8(7), 1414-1420.
https://doi.org/10.1039/C7MD00164A, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa52212
Brancale, A., Shailubhai, K., Ferla, S., Ricci, A., Bassetto, M., & Jacob, G. (2017). Therapeutically targeting guanylate cyclase-C: computational modeling of plecanatide, a uroguanylin analog. Pharmacology Research & Perspectives, 5(2), e00295
https://doi.org/10.1002/prp2.295, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa52211
Bassetto, M., Leyssen, P., Neyts, J., Yerukhimovich, M., Frick, D., & Brancale, A. (2017). Shape-based virtual screening, synthesis and evaluation of novel pyrrolone derivatives as antiviral agents against HCV. Bioorganic & Medicinal Chemistry Letters, 27(4), 936-940.
https://doi.org/10.1016/j.bmcl.2016.12.087, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa52210
Bassetto, M., Leyssen, P., Neyts, J., Yerukhimovich, M., Frick, D., Courtney-Smith, M., & Brancale, A. (2017). In silico identification, design and synthesis of novel piperazine-based antiviral agents targeting the hepatitis C virus helicase. European Journal of Medicinal Chemistry, 125, 1115-1131.
https://doi.org/10.1016/j.ejmech.2016.10.043, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa52209
Ferla, S., Bassetto, M., Ferla, S., Pertusati, F., Kandil, S., Westwell, A., Brancale, A., & McGuigan, C. (2016). Design and synthesis of novel bicalutamide and enzalutamide derivatives as antiproliferative agents for the treatment of prostate cancer. European Journal of Medicinal Chemistry, 118, 230-243.
https://doi.org/10.1016/j.ejmech.2016.04.052, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa52205
Bassetto, M., Leyssen, P., Neyts, J., Yerukhimovich, M., Frick, D., & Brancale, A. (2016). Computer-aided identification, synthesis and evaluation of substituted thienopyrimidines as novel inhibitors of HCV replication. European Journal of Medicinal Chemistry, 123, 31-47.
https://doi.org/10.1016/j.ejmech.2016.07.035, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa52206
Bassetto, M., Massarotti, A., Coluccia, A., & Brancale, A. (2016). Structural biology in antiviral drug discovery. Current Opinion in Pharmacology, 30, 116-130.
https://doi.org/10.1016/j.coph.2016.08.014, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa52207
Ferla, S., Bassetto, M., Pertusati, F., Kandil, S., Westwell, A., Brancale, A., & McGuigan, C. (2016). Rational design and synthesis of novel anti-prostate cancer agents bearing a 3,5-bis-trifluoromethylphenyl moiety. Bioorganic & Medicinal Chemistry Letters, 26(15), 3636-3640.
https://doi.org/10.1016/j.bmcl.2016.06.001, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa54208
http://orca.cf.ac.uk/91515/
Brancale, A., Shailubhai, K., Ferla, S., Ricci, A., Bassetto, M., Jacob, G., Ferla, S., & Bassetto, M. (2016). Mo1316 Structural and Dynamic Features of Plecanatide: Insights From Molecular Dynamics Simulations. Gastroenterology, 150(4), S695
https://doi.org/10.1016/s0016-5085(16)32373-3, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa55497
Cancellieri, M., Bassetto, M., Widjaja, I., van Kuppeveld, F., de Haan, C., & Brancale, A. (2015). In silico structure-based design and synthesis of novel anti-RSV compounds. Antiviral Research, 122, 46-50.
https://doi.org/10.1016/j.antiviral.2015.08.003, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa52203
Bassetto, M., Ferla, S., & Pertusati, F. (2015). Polyfluorinated groups in medicinal chemistry. Future Medicinal Chemistry, 7(4), 527-546.
https://doi.org/10.4155/fmc.15.5, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa52202
Bassetto, M., Ferla, S., Leyssen, P., Neyts, J., Yerukhimovich, M., Frick, D., O’Donnell, R., & Brancale, A. (2015). Novel symmetrical phenylenediamines as potential anti-hepatitis C virus agents. Antiviral Chemistry and Chemotherapy, 24(5-6), 155-160.
https://doi.org/10.1177/2040206616676353, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa55499
Wang, X., Liu, L., Huang, L., Herbst-Robinson, K., Cornec, A., James, M., Sugiyama, S., Bassetto, M., Brancale, A., Trojanowski, J., Lee, V., Smith, A., Brunden, K., & Ballatore, C. (2014). Potent, Long-Acting Cyclopentane-1,3-Dione Thromboxane (A2)-Receptor Antagonists. ACS Medicinal Chemistry Letters, 5(9), 1015-1020.
https://doi.org/10.1021/ml5002085, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa52201
Romagnoli, R., Baraldi, P., Lopez-Cara, C., Salvador, M., Preti, D., Tabrizi, M., Balzarini, J., Nussbaumer, P., Bassetto, M., Brancale, A., Fu, X., Yang-Gao, ., Li, J., Zhang, S., Hamel, E., Bortolozzi, R., Basso, G., & Viola, G. (2014). Design, synthesis and biological evaluation of 3,5-disubstituted 2-amino thiophene derivatives as a novel class of antitumor agents. Bioorganic & Medicinal Chemistry, 22(18), 5097-5109.
https://doi.org/10.1016/j.bmc.2013.12.030, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa52200
Bassetto, M., De Burghgraeve, T., Delang, L., Massarotti, A., Coluccia, A., Zonta, N., Gatti, V., Colombano, G., Sorba, G., Silvestri, R., Tron, G., Neyts, J., Leyssen, P., & Brancale, A. (2013). Computer-aided identification, design and synthesis of a novel series of compounds with selective antiviral activity against chikungunya virus. Antiviral Research, 98(1), 12-18.
https://doi.org/10.1016/j.antiviral.2013.01.002, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa52199
Romagnoli, R., Baraldi, P., Lopez-Cara, C., Preti, D., Aghazadeh Tabrizi, M., Balzarini, J., Bassetto, M., Brancale, A., Fu, X., Gao, Y., Li, J., Zhang, S., Hamel, E., Bortolozzi, R., Basso, G., & Viola, G. (2013). Concise Synthesis and Biological Evaluation of 2-Aroyl-5-Amino Benzo[b]thiophene Derivatives As a Novel Class of Potent Antimitotic Agents. Journal of Medicinal Chemistry, 56(22), 9296-9309.
https://doi.org/10.1021/jm4013938, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa52198
Romagnoli, R., Baraldi, P., Kimatrai Salvador, M., Preti, D., Aghazadeh Tabrizi, M., Bassetto, M., Brancale, A., Hamel, E., Castagliuolo, I., Bortolozzi, R., Basso, G., & Viola, G. (2013). Synthesis and Biological Evaluation of 2-(Alkoxycarbonyl)-3-Anilinobenzo[b]thiophenes and Thieno[2,3-b]pyridines as New Potent Anticancer Agents. Journal of Medicinal Chemistry, 56(6), 2606-2618.
https://doi.org/10.1021/jm400043d, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa52197
Romagnoli, R., Baraldi, P., Salvador, M., Camacho, M., Preti, D., Tabrizi, M., Bassetto, M., Brancale, A., Hamel, E., Bortolozzi, R., Basso, G., & Viola, G. (2012). Synthesis and biological evaluation of 2-substituted-4-(3′,4′,5′-trimethoxyphenyl)-5-aryl thiazoles as anticancer agents. Bioorganic & Medicinal Chemistry, 20(24), 7083-7094.
https://doi.org/10.1016/j.bmc.2012.10.001, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa52196

Penodau Llyfrau

Bassetto, M. & Brancale, A. (2021). The search for antivirals to treat alphavirus infections. Annual Reports in Medicinal Chemistry (pp. 133-151). Elsevier
https://doi.org/10.1016/bs.armc.2021.09.002, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa58368

Goruchwyliaeth

Novel synthetic fillers for Mixed Matrix Membranes (MMMs). (cyfredol)

PhD

Goruchwyliwr arall: Dr Mariolino Carta
Novel Porous Polymers as Flame Retardant and Gas Separation Materials (cyfredol)

PhD

Goruchwyliwr arall: Dr Martin Gill

Goruchwyliwr arall: Dr Mariolino Carta
Computer-Aided Design, Synthesis, and Evaluation of Novel Broad-Spectrum Antiviral Agents (dyfarnwyd 2024)

PhD

Goruchwyliwr arall: Dr Mariolino Carta

Modiwlau a Addysgir

PMNM11 Nanomedicines, pharmaceuticals and advanced therapeutics

This module will explore the history and development of molecular medicines and pharmaceuticals, providing the basis for an advanced understanding of next generation therapeutic approaches. Using landmark technology and chemical development phases informed by separation science and mass spectrometry, the module uses an application driven approach to provide the student with an extensive knowledgebase of drug development, the pharmaceutical industry and nanotherapeutics. Students will be able to characterize and map the path of a drug from administration, to metabolism and elimination, and critically evaluate drug design and delivery approaches. Traditional small chemical entities used in molecular medicine will be outlined, using drugs such as taxols and tamoxifen as exemplars. Common target oncology and non-oncology disorders will provide the context; with students encouraged to explore targeted nanoparticle fabrication, drug encapsulation and release profiling, from early first generation drugs such as Abraxane to second generation biologically targeted SMART delivery systems. Future molecular medicines such as antibody drug conjugates and kinase inhibitors will be taught by guest lectures from industry and clinicians, covering the spectrum of drug development to delivery and clinical considerations.

Grantiau a Phrosiectau Allweddol

Novel therapeutics to treat schistosomiasis: development of a new approach based on nucleoside analogues 2019

Wellcome Trust ISSF3 Consolidator Award (Cyd-ymchwilydd)
Development of novel treatments against inherited blinding diseases retinitis pigmentosa and Leber's congenital amaurosis 2018

Wellcome Trust ISSF3 Translational Kickstart Award (Prif Ymchwilydd)
Computer-aided design, synthesis and evaluation of novel antiviral agents against Norovirus 2018

Wellcome Trust ISSF3 Translational Kickstart Award (Prif Ymchwilydd)
Novel therapeutic strategies to overcome opsin misfolding and aggregation in retinal blinding diseases 2017

Academy of Medical Sciences Springboard Award (Prif Ymchwilydd)
Vector-borne emerging diseases: computer-aided design, synthesis and biological evaluation of novel antiviral compounds against Chikungunya and Zika viruses 2016

Cymrodoriaeth Ymchwil Unigol Llywodraeth Cymru-Sêr Cymru II

Dr Marcella Bassetto

Cyfeiriad ebost

Dolenni Ymchwil

Trosolwg

Meysydd Arbenigedd

Cyhoeddiadau

Uchafbwyntiau Ymchwil

Holl Ymchwil

Erthyglau Cylchgronau

Penodau Llyfrau

Goruchwyliaeth

Novel synthetic fillers for Mixed Matrix Membranes (MMMs). (cyfredol)

Novel Porous Polymers as Flame Retardant and Gas Separation Materials (cyfredol)

Computer-Aided Design, Synthesis, and Evaluation of Novel Broad-Spectrum Antiviral Agents (dyfarnwyd 2024)

Modiwlau a Addysgir

PMNM11 Nanomedicines, pharmaceuticals and advanced therapeutics

Grantiau a Phrosiectau Allweddol

Novel therapeutics to treat schistosomiasis: development of a new approach based on nucleoside analogues 2019

Development of novel treatments against inherited blinding diseases retinitis pigmentosa and Leber's congenital amaurosis 2018

Computer-aided design, synthesis and evaluation of novel antiviral agents against Norovirus 2018

Novel therapeutic strategies to overcome opsin misfolding and aggregation in retinal blinding diseases 2017

Vector-borne emerging diseases: computer-aided design, synthesis and biological evaluation of novel antiviral compounds against Chikungunya and Zika viruses 2016