Dr Ruth Godfrey

• AN ANALYTICAL AND EPIGENETIC IN-VESTIGATION OF THE ENVIRONMENTAL AND HUMAN HEALTH IMPACTS OF PER- AND POLYFLUOROALKYL ´FOREVER CHEMICALS´ (current)

  PhD

• PM-273 Advances in Toxicology: Pick Your Poison

  We are surrounded by substances that may do our bodies harm i.e. poisons. The harm these poisons causes depends on our exposure - the dose. The science of toxicology, a discipline that crosscuts biology, chemistry, pharmacology, and medicine, is based on the principle that the dose makes the poison. This module is compulsory for BSc Medical Pharmacology students and acts as a follow on from PM-147 Introduction to Toxicology: The Dose Makes the Poison. This module will provide students with the opportunity to expand their toxicology knowledge and apply it to three distinct fields within toxicology; analytical toxicology, forensic toxicology and clinical toxicology. Students will learn about the experimental procedures and techniques we employ for the isolation and detection of compounds as well as their effects on biological systems. Students will then learn about the role of employing these methods in the field of forensic toxicology and the role of toxicology within the legal system. Within the module, students will also learn about the role of clinical toxicology and patient presentation following poisoning events and the techniques we have for detection and treatment of toxicology within the clinical setting.

• PM-344 Capstone Project

  The aim of this module is to provide a capstone experience to students¿ learning, through participating in their own enquiry-based research project, with guidance from an academic supervisor. The project may be laboratory or non-laboratory based, but it will always involve a research question that is drawn from the literature, and focused on a topic relevant to the life sciences. It will ask a research question and involve the critical analysis of research findings. Students will refine their oral and written communication skills to a graduate level through an oral presentation and dissertation on their research findings and conclusions.

• PM-355 Drug Development and Regulation

  This is an applications and project management driven module designed to provide the student with an introduction to drug development and the key role of separation science and mass spectrometry within the pharmaceutical industry. This module will introduce Good Laboratory, Clinical and Manufacturing Practice (GLP, GCP, GMP), assay validation (as requested by the Food and Drug Administration (FDA)), the need and implementation of SOPs with particular focus on the pharmaceutical and medical industries, and how these correlate with stringent quality control procedures and health and safety existing due to current legislation. The ethical principles of research, including clinical trials and animal research (design, implementation and reporting) will be outlined, as well as the essential nature of the principles of reduction, refinement and replacement for the use of animals in research. Students will also be able to characterize and map the path of a drug from administration, to metabolism and elimination, for critical evaluation of drug design.

• PMC100 Chemistry for Biochemists

  The module covers transition metals, elements of bio-inorganic chemistry, forensic chemistry, antibody-drug conjugate chemistry, the chemistry of nanoparticles and the chemistry of biosensors.

• PMC102 Chemical Analysis: from Composition to Structure Elucidation; an Introduction for Life Sciences.

  This module deals with the principles and practice of analytical chemistry and gives an introduction to a number of important instrumental techniques in analytical chemistry for both quantitative and qualitative analysis and structure elucidation.

• PMLM00 Mass Spectrometry - basics and fundamentals

  This module will enable students to gain a sound knowledgebase of the basic concepts of mass spectrometry including the individual components, linking to modern separation techniques, instrument maintenance, spectral interpretation, and the basis of modern applications such as, compound identification by generating a characteristic mass `fingerprint¿ for the chemical structure and compound quantitation.

• PMLM01 Laboratory Measurement Techniques for Medicinal Chemistry and Nanomedicine

  This module will enable students to understand the basic and advanced concepts of measurement techniques used in medicinal chemistry and nanomedicine, how they may be applied with relevant methods of detection, gain `hands on¿ problem solving experience and strategic method development for complete bioanalysis according to target molecule characteristics and method application.

• PMLM22 Laboratory Measurement Techniques for Medical Sciences

  This module will enable students to understand the basic and advanced concepts of laboratory and measurement techniques used in medical sciences, how they may be applied with relevant methods of detection, gain `hands on¿ problem solving experience and strategic method development for complete bioanalysis according to target molecule characteristics and method application.

• PMNM11 Nanomedicines, pharmaceuticals and advanced therapeutics

  This module will explore the history and development of molecular medicines and pharmaceuticals, providing the basis for an advanced understanding of next generation therapeutic approaches. Using landmark technology and chemical development phases informed by separation science and mass spectrometry, the module uses an application driven approach to provide the student with an extensive knowledgebase of drug development, the pharmaceutical industry and nanotherapeutics. Students will be able to characterize and map the path of a drug from administration, to metabolism and elimination, and critically evaluate drug design and delivery approaches. Traditional small chemical entities used in molecular medicine will be outlined, using drugs such as taxols and tamoxifen as exemplars. Common target oncology and non-oncology disorders will provide the context; with students encouraged to explore targeted nanoparticle fabrication, drug encapsulation and release profiling, from early first generation drugs such as Abraxane to second generation biologically targeted SMART delivery systems. Future molecular medicines such as antibody drug conjugates and kinase inhibitors will be taught by guest lectures from industry and clinicians, covering the spectrum of drug development to delivery and clinical considerations.

• PMZM00A A general introduction to small molecule mass spectrometry

  This module will enable students to gain knowledge of the basic concepts of small molecule mass spectrometry including typical instrumentation, linking to modern separation techniques, principles of valid analytical measurement and instrument maintenance, spectral interpretation, and the basis of modern applications such as, compound identification by generating a characteristic mass `fingerprint¿ for the chemical structure and compound quantitation.

• PMZM00B A general introduction to small molecule mass spectometry

  This module will enable students to gain knowledge of the basic concepts of small molecule mass spectrometry including typical instrumentation, linking to modern separation techniques, principles of valid analytical measurement and instrument maintenance, spectral interpretation, and the basis of modern applications such as, compound identification by generating a characteristic mass `fingerprint¿ for the chemical structure and compound quantitation.

• Avenues of Commercialisation for Nano and Micro (ACNM) Technologies 2018 - 2021

  Co-investigator, EU funded, with Dr L Francis (SUMS PI), £1.3M

• Multi-inlet comprehensive gas chromatography and high resolution mass spectrometry 2019 - 2022

  Co-investigator, funded by EPSRC., £856,023

• Sampling and Analysis of Hexabromocyclododecane (HBCDD) in Environment Samples by Liquid Chromatography Mass Spectrometry 2018

  Primary investigator, funded by Natural Resources Wales (NRW)., Equivalent of ~£17.4k

• A qualitative investigation of industrial sludge samples using hyphenated mass spectrometry 2018 - 2019

  Primary investigator, funded by KESS and Hydro Industries Ltd, with Dr R Thomas, ~£17.4k

• Application of gas chromatography-mass spectrometry (GC-MS) in the quantative analysis of organic analytes generated in gasification/pyrolysis coupled Fischer Tropsch (FT) reactor: syngas clean-up and hydrocarbon production 2015 - 2019

  Primary investigator, funded by Decus Research/Hendre Holdings Ltd, with Prof S Kelly, Equivalent to ~£60k

• Mass spectrometric investigation of pharmaceuticals in environmental matrices: homogenate analysis 2015 - 2019

  Primary investigator, funded by EPSRC, with Dr G Van Keulan, ~£60k

• Development and feasibility of a Flowing Atmospheric Pressure Afterglow (FAPA) Discharge ionisation source 2015 - 2017

  Primary investigator, funded by KESS and Water Corp., with Prof G Brenton, ~£17.4k

• Development of advanced ionisation techniques for mass spectrometry 2013 - 2017

  Co-investigator, funded by EPSRC, with Prof G Brenton, ~£60k

• Development of sample preparation technologies for environmental matrices 2013 - 2014

  Two projects, primary investigator, funded by Access-to-Masters and Biotage GB Ltd, with Prof G Brenton, ~£29k

• Development of sample preparation technologies for clinical matrices 2013 - 2015

  Two projects, primary investigator, funded by Access-to-Masters and Porvair Filtration Group, with Prof G Brenton, ~£29k

• Associate Professor, Swansea University

  March 2020 - Present

• Senior Lecturer, Swansea University

  March 2017 - February 2020

• Lecturer, Swansea University

  August 2011 - February 2017

• Research Assistant, Swansea University

  February 2008 - July 2011

• PhD Researcher, Swansea University

  September 2004 - February 2008

• Research Technician, Simbec Research Ltd

  June 2002 - September 2003

• Committee Secretary and Member, RSC Analytical Methods Committee

  2015 - Present

• Member, Royal Society of Chemistry

  2012 - Present

• Member, RSC Scheme Qualifications and Accreditation Committee

  2016 - Present

• Member, Mass Spectrometry Sub-committee of the RSC

  2010 - 2015

• Member, British Mass Spectrometry Society (BMSS)

  2004 - Present

• Member, American Society for Mass Spectrometry (ASMS)

  2005 - Present

• Member, Chromatographic Society (ChromSoc)

  2004 - Present

• External Examiner, University of Plymouth

  2018 - 2022

• Review Editor, Frontiers in Environmental Chemistry

  2020 - Present

• Member of the Scientific Organising Committee and Session Chair, RSC Faraday Discussion:Challenges in analysis of complex mixture

  2019 - 2019

• Member of the Scientific Organising Committee and Session Chair, Hyphenated Technologies Conference

  2018 - 2018

• Reviewer, Journal of Environmental Management

  2019 - Present

• Reviewer, Journal of Chromatography A

  2011 - Present

• Reviewer, Analytical Bioanalytical Chemistry

  2012 - Present

• Reviewer, Journal of Chromatography B

  2008 - Present

• Reviewer, Journal of Pharmaceutical and Biomedical Analysis

  2010 - Present

• Grant Reviewer, UKRI

  2018 - Present

• Ambassador, RSC Chemnet

  2010 - Present

Birmingham Green Heart Festival (mass spectrometry demonstration to general public)

RSC Chemnet Ambassador

• Hyphenated Technologies Conference

  2020

  Belgium

• Waste Water Environmental Monitoring

  2018

  UK

• Hyphenated Technologies Conference

  2018

  UK

• Analytical Science Network - Emerging Analytical Professionals

  2015

  UK