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PM-148
Foundations of Community Medicine
Communities now play a key role in improving and sustaining good health and the delivery of care. This has led to the development of a new field within medical education and practice called Community Medicine. Community Medicine is often considered synonymous with Preventative and Social Medicine (PSM), Public Health, and Community Health because of a shared concern with the prevention of disease and promotion of health and wellbeing. This module introduces students to the wide range of approaches encompassed within Community Medicine. These include preventative, promotive, curative and rehabilitative approaches aimed at improving population health through community-based health and care.
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PM-149
Genetics, Genomics & Evolution
The module will provide a foundation in genetics and evolution. Concepts such as DNA discovery, structure and replication, gene transcription and translation, mechanisms of gene transmission, genome organisation, epigenetic modifications and mutations will be covered with an appreciation of how how these mechanisms have an impact on human disease and antibiotic resistance.
The latter part of the module will start with the work of Plato, Cuvier, Lamarck, Wallace and Darwin and how they (and others) influenced the development of an evolutionary theory framework. Using this knowledge the module will then look at the processes involved in speciation and how they can be applied at both the gene and whole organismal level.
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PM-152
Population Genomics
Population genomics is the study of genetic variation within populations and involves the examination of changes in the frequency of gene and alleles across space and time. Concepts such as natural selection, genetic drift, gene pool, genetic diversity, migration and environmental diversity all contribute to create genetic diversity within sub populations. Students will be taught these key concepts along with the real life sub populations examples where genotype variation has led to the diversity in genetics. Such as, the prevalence of disease in the specific populations, the evolution of genetically distinct populations and the genomics behind genetic diversity in sport. This module will take you across the world in multidisciplinary topics and show how genomics is weaved throughout, to create the strengths, weakness, and purely, what makes us who we are.
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PM-252
Molecular Evolution
The module aims to critically evaluate concepts and apply the scientific methods pertaining to the study of molecular evolution, in prokaryotic and eukaryotic organisms.
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PM-267
Pharmacogenomics: Genes on Drugs
Pharmacogenomics is the study of how a person¿s genomic information can affect their response to drugs and therapeutics, predicting if a patient will respond badly, too much or too little to a chosen therapy. This is the underlying principle of `personalised medicine¿, ensuring the right patient, gets the right drug, at the right time.
Within this module, students will look at the principles of pharmacogenomics, namely the variation in genomic sequences from patient to patient which can alter the pharmacokinetics and pharmacodynamics of therapeutics. In this module, students will learn about the role of pharmacogenomics in chemotherapy, gastrointestinal drugs, cardiovascular drugs, respiratory drugs, neurological drugs and drugs used in the treatment of infectious disease.
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PM-317
Genetics of Cancer
This module extensively explores the molecular and genetic foundations underlying key aspects of cancer, including angiogenesis, apoptosis, cell signalling, DNA damage, molecular pathology, invasion and metastasis, inflammation, and the Warburg effect. Expert insights will be shared by a consultant gastroenterologist and a consultant pathologist during select lectures. This approach aims to offer students a well-rounded understanding that integrates academic knowledge, research insights, and practical clinical expertise.
Additionally, the module seeks to broaden students' perspectives by dedicating a final lecture to an individual who shares firsthand experiences of living with cancer. This unique session provides students with valuable insights into the human aspect of the disease, fostering empathy and a deeper appreciation of the patient's journey.
An appreciation for the way in which an individual¿s own genome can influence diagnosis, prognosis and treatment is also included.
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PM-344
Capstone Project
The aim of this module is to provide a capstone experience to students¿ learning, through participating in their own enquiry-based research project, with guidance from an academic supervisor. The project may be laboratory or non-laboratory based, but it will always involve a research question that is drawn from the literature, and focused on a topic relevant to the life sciences. It will ask a research question and involve the critical analysis of research findings. Students will refine their oral and written communication skills to a graduate level through an oral presentation and dissertation on their research findings and conclusions.
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PM-354
Cancer Pharmacology
Cancer remains a significant cause of mortality in the modern world. Current and emerging chemotherapies, and the rationale, experimental, and clinical evidence of the pathways or molecules targeted will be explored. Causes of treatment-related side effects, and the therapies used to address these, will be discussed along with the mechanisms that lead to anti-cancer drug resistance.
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PM-400
Advanced Research Project A
The advanced research project is a key component of the final year of study, providing students with experience of conducting cutting-edge research in the Institute of Life Science and Centre for Nanohealth over an extended period of time. The project will fall into one of the current medically-related research themes: Biomarkers and Genes; Microbes and Immunity; Devices and health informatics. Students will employ a range of advanced analytical procedures to investigate a specific topic. In addition, they will gain experience in preparing a research proposal and presenting their data in various formats. Research topics will be assigned that are appropriate to a specific degree title. For example, a Genetics student could be assigned a project investigating gene function in an insect vector of a tropical disease, using the technique of RNA interference.
The advanced research project is divided between 2 modules, PM-400 and PM-405.
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PM-405
Advanced Research Project Dissertation
The advanced research project is a key component of the final year of study, providing students with experience of conducting cutting-edge research in the Institute of Life Science and Centre for Nanohealth over an extended period. The projects undertaken will fall into one of the current medically-related research themes. Students will employ a range of advanced analytical procedures to investigate a specific topic. In addition, they will gain experience in preparing a research proposal and presenting their data in various formats. Research topics will be assigned that are appropriate to a specific degree title.
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PMGM11
Introduction to Human Genetics and Genomics
The Introduction to Human Genetics and Genomics module is a subject-specific module in the MSc Genomic Medicine programme. This unit will provide essential and contemporary knowledge relating to genetic science and genetic disease. The module will prepare participants to understand disease genetics, how genomic medicine can be utilised to elucidate disease mechanisms and biology in the context of genomic medicine. It will provide core knowledge underpinning later modules.
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PMGM15
Application of Genomics in Infectious Disease
In this module the student will learn about the genomic structure of infectious agents, implication of acquisition or loss of nucleotides, genes and plasmids on pathogenicity, sensitivity of a pathogen to drug treatment and outbreak control.
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PMGM16
Genomics of Common and Rare Inherited Disease
This module will provide an introduction to the clinical presentation and manifestations of rare inherited and common diseases, and considers the patient and family perspective with respect to the role and impact of genomics. It reviews traditional and current strategies and techniques used to identify genes responsible for both common multifactorial and rare inherited diseases.
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PMGM17
Post Graduate Taught Masters Dissertation
The module is for students to build on their previous knowledge, skills and experience by undertaking a laboratory based or suitable non-laboratory based project on a specific subject related to genomics.
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SHT101
Foundation Sciences for Occupation
This module will examine foundation sciences needed to understand occupational engagement throughout the lifespan. This module explores fundamental sciences linked to the human body and behavioural sciences relevant to understanding occupations. Learners will explore fundamental concepts of human anatomy, physiology, psychology and sociology. This module is designed to help understanding of occupational interruption in later modules.
