Dr Gill Conway

Senior Research Officer - CutCancer

Biomedical Sciences

+44 (0) 1792 295230

gillian.conway@swansea.ac.uk

Open Plan Office - 403
Fourth Floor
Institute of Life Science 1
Singleton Campus

Available For Postgraduate Supervision

Research Links

https://orcid.org/0000-0002-5991-0960

Google Scholar

About

Dr. Conway is a Research officer and lab manager in the In Vitro Toxicology group within Swansea University Medical School. She completed her BSc in Bio-molecular Science and a PhD in the area of molecular biology and cancer therapeutics at the Technological University Dublin, Ireland. She has also previously worked at the National Institute for Bioprocessing research and training (NIBRT) in Ireland before coming to Swansea University.

Areas Of Expertise

Cancer biology
Advanced in vitro cellular models
Nutraceuticals
Cell signalling
Genetic Toxicology
DNA damage

Career Highlights

Research

Dr. Conway is part of the In Vitro Toxicology Group led by Prof Shareen Doak. Her research within the group focuses on the development of predictive in vitro models and bioassays to support engineered nanomaterial hazard assessment. The overarching aim of these developments is to reduce the reliance on animal experimentation.

Gillian also has a particular interest in investigating novel therapeutic approaches for the treatment of cancer. Improvements in the detection and treatment of cancer has led to increased average survival rates that are now six times longer than those reported forty years ago. However, a number of cancers remain resistant to most treatments, resulting in a high rate of tumour reoccurrence. Gillian’s research focuses on the investigation of naturally derived bioactive compounds as novel therapeutic approaches for the treatment of brain cancer.

Award Highlights Collaborations

Publications

Research Highlights

Llewellyn, S., Kermanizadeh, A., Ude, V., Jacobsen, N., Conway, G., Shah, U., Niemeijer, M., Moné, M., Water, B., Roy, S., Moritz, W., Stone, V., Jenkins, G., & Doak, S. (2022). Assessing the transferability and reproducibility of 3D in vitro liver models from primary human multi-cellular microtissues to cell-line based HepG2 spheroids. Toxicology in Vitro, 85, 105473
https://doi.org/10.1016/j.tiv.2022.105473, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61191
He, Z., Charleton, C., Devine, R., Kelada, M., Walsh, J., Conway, G., Gunes, S., Mondala, J., Tian, F., Tiwari, B., Kinsella, G., Malone, R., O'Shea, D., Devereux, M., Wang, W., Cullen, P., Stephens, J., & Curtin, J. (2021). Enhanced pyrazolopyrimidinones cytotoxicity against glioblastoma cells activated by ROS-Generating cold atmospheric plasma. European Journal of Medicinal Chemistry, 224, 113736
https://doi.org/10.1016/j.ejmech.2021.113736, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa65435
Metcalfe, R., Kemp, R., Heffernan, S., Churm, R., Chen, Y., Ruffino, J., Conway, G., Tornillo, G., & Orange, S. (2021). Anti-carcinogenic effects of exercise-conditioned human serum: evidence, relevance and opportunities. European Journal of Applied Physiology, 121
https://doi.org/10.1007/s00421-021-04680-x, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56708
Llewellyn, S., Conway, G., Zanoni, I., Jørgensen, A., Shah, U., Seleci, D., Keller, J., Kim, J., Wohlleben, W., Jensen, K., Costa, A., Jenkins, G., Clift, M., & Doak, S. (2021). Understanding the impact of more realistic low-dose, prolonged engineered nanomaterial exposure on genotoxicity using 3D models of the human liver. Journal of Nanobiotechnology, 19(1)
https://doi.org/10.1186/s12951-021-00938-w, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa57237
Llewellyn, S., Niemeijer, M., Nymark, P., Moné, M., Water, B., Conway, G., Jenkins, G., & Doak, S. (2021). In Vitro Three‐Dimensional Liver Models for Nanomaterial DNA Damage Assessment. Small, 17(15), 2006055
https://doi.org/10.1002/smll.202006055, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56073
Heffernan, S. & Conway, G. (2021). Nutraceutical Alternatives to Pharmaceutical Analgesics in Osteoarthritis. Pain Management - Practices, Novel Therapies and Bioactives IntechOpen
https://doi.org/10.5772/intechopen.95919, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa65436
Conway, G., Shah, U., Llewellyn, S., Cervena, T., Evans, S., Al-Ali, A., Jenkins, G., Clift, M., & Doak, S. (2020). Adaptation of the in vitro micronucleus assay for genotoxicity testing using 3D liver models supporting longer-term exposure durations. Mutagenesis, 35(4), 319-329.
https://doi.org/10.1093/mutage/geaa018, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa54991
Llewellyn, S., Conway, G., Shah, U., Evans, S., Jenkins, G., Clift, M., & Doak, S. (2020). Advanced 3D Liver Models for In vitro Genotoxicity Testing Following Long-Term Nanomaterial Exposure. Journal of Visualized Experiments(160)
https://doi.org/10.3791/61141, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa54416
Conway, G., Heffernan, S., Horner, K., De Vito, G., & Conway, G. (2019). The Role of Mineral and Trace Element Supplementation in Exercise and Athletic Performance: A Systematic Review. Nutrients, 11(3), 696
https://doi.org/10.3390/nu11030696, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa51435
Conway, G., He, Z., Hutanu, A., Cribaro, G., Manaloto, E., Casey, A., Traynor, D., Milosavljevic, V., Howe, O., Barcia, C., Murray, J., Cullen, P., & Curtin, J. (2019). Cold Atmospheric Plasma induces accumulation of lysosomes and caspase-independent cell death in U373MG glioblastoma multiforme cells. Scientific Reports, 9(1)
https://doi.org/10.1038/s41598-019-49013-3, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa55404
He, Z., Liu, K., Manaloto, E., Casey, A., Cribaro, G., Byrne, H., Tian, F., Barcia, C., Conway, G., Cullen, P., & Curtin, J. (2018). Cold Atmospheric Plasma Induces ATP-Dependent Endocytosis of Nanoparticles and Synergistic U373MG Cancer Cell Death. Scientific Reports, 8(1)
https://doi.org/10.1038/s41598-018-23262-0, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa51508
Conway, G., Casey, A., Milosavljevic, V., Liu, Y., Howe, O., Cullen, P., & Curtin, J. (2016). Non-thermal atmospheric plasma induces ROS-independent cell death in U373MG glioma cells and augments the cytotoxicity of temozolomide. British Journal of Cancer, 114(4), 435-443.
https://doi.org/10.1038/bjc.2016.12, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa55405
Conway, G., Zizyte, D., Mondala, J., He, Z., Lynam, L., Lecourt, M., Barcia, C., Howe, O., & Curtin, J. (2021). Ursolic Acid Inhibits Collective Cell Migration and Promotes JNK-Dependent Lysosomal Associated Cell Death in Glioblastoma Multiforme Cells. Pharmaceuticals, 14(2), 91
https://doi.org/10.3390/ph14020091, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa65440
Ummat, V., Sivagnanam, S., Rai, D., O’Donnell, C., Conway, G., Heffernan, S., Fitzpatrick, S., Lyons, H., Curtin, J., & Tiwari, B. (2024). Conventional extraction of fucoidan from Irish brown seaweed Fucus vesiculosus followed by ultrasound-assisted depolymerization. Scientific Reports, 14(1)
https://doi.org/10.1038/s41598-024-55225-z, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa65672
Suh, M., Park, J., Ko, G., Kim, J., Hwang, D., Rees, L., Conway, G., Doak, S., Kang, H., Lee, N., Hyeon, T., Lee, Y., & Lee, D. (2024). Optimization of micelle-encapsulated extremely small sized iron oxide nanoparticles as a T1 contrast imaging agent: biodistribution and safety profile. Journal of Nanobiotechnology, 22(1)
https://doi.org/10.1186/s12951-024-02699-8, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa67147
John, K., Page, J., Heffernan, S., Conway, G., Bezodis, N., Kilduff, L., Clark, B., Périard, J., & Waldron, M. (2024). The effect of a 4-week, remotely administered, post-exercise passive leg heating intervention on determinants of endurance performance. European Journal of Applied Physiology, 0
https://doi.org/10.1007/s00421-024-05558-4, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa67172
Heffernan, S., Conway, G., McCarthy, C., Eustace, S., Waldron, M., Vito, G., & Delahunt, E. (2024). Inflammatory markers in early knee joint osteoarthritis differ from well-matched controls and are associated with consistent, rather than intermittent knee pain. The Knee, 51, 189-198.
https://doi.org/10.1016/j.knee.2024.09.003, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa67729

All Research

Journal Articles

Heffernan, S., Conway, G., McCarthy, C., Eustace, S., Waldron, M., Vito, G., & Delahunt, E. (2024). Inflammatory markers in early knee joint osteoarthritis differ from well-matched controls and are associated with consistent, rather than intermittent knee pain. The Knee, 51, 189-198.
https://doi.org/10.1016/j.knee.2024.09.003, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa67729
John, K., Page, J., Heffernan, S., Conway, G., Bezodis, N., Kilduff, L., Clark, B., Périard, J., & Waldron, M. (2024). The effect of a 4-week, remotely administered, post-exercise passive leg heating intervention on determinants of endurance performance. European Journal of Applied Physiology, 0
https://doi.org/10.1007/s00421-024-05558-4, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa67172
Suh, M., Park, J., Ko, G., Kim, J., Hwang, D., Rees, L., Conway, G., Doak, S., Kang, H., Lee, N., Hyeon, T., Lee, Y., & Lee, D. (2024). Optimization of micelle-encapsulated extremely small sized iron oxide nanoparticles as a T1 contrast imaging agent: biodistribution and safety profile. Journal of Nanobiotechnology, 22(1)
https://doi.org/10.1186/s12951-024-02699-8, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa67147
Ummat, V., Sivagnanam, S., Rai, D., O’Donnell, C., Conway, G., Heffernan, S., Fitzpatrick, S., Lyons, H., Curtin, J., & Tiwari, B. (2024). Conventional extraction of fucoidan from Irish brown seaweed Fucus vesiculosus followed by ultrasound-assisted depolymerization. Scientific Reports, 14(1)
https://doi.org/10.1038/s41598-024-55225-z, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa65672
Llewellyn, S., Kermanizadeh, A., Ude, V., Jacobsen, N., Conway, G., Shah, U., Niemeijer, M., Moné, M., Water, B., Roy, S., Moritz, W., Stone, V., Jenkins, G., & Doak, S. (2022). Assessing the transferability and reproducibility of 3D in vitro liver models from primary human multi-cellular microtissues to cell-line based HepG2 spheroids. Toxicology in Vitro, 85, 105473
https://doi.org/10.1016/j.tiv.2022.105473, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61191
He, Z., Charleton, C., Devine, R., Kelada, M., Walsh, J., Conway, G., Gunes, S., Mondala, J., Tian, F., Tiwari, B., Kinsella, G., Malone, R., O'Shea, D., Devereux, M., Wang, W., Cullen, P., Stephens, J., & Curtin, J. (2021). Enhanced pyrazolopyrimidinones cytotoxicity against glioblastoma cells activated by ROS-Generating cold atmospheric plasma. European Journal of Medicinal Chemistry, 224, 113736
https://doi.org/10.1016/j.ejmech.2021.113736, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa65435
Metcalfe, R., Kemp, R., Heffernan, S., Churm, R., Chen, Y., Ruffino, J., Conway, G., Tornillo, G., & Orange, S. (2021). Anti-carcinogenic effects of exercise-conditioned human serum: evidence, relevance and opportunities. European Journal of Applied Physiology, 121
https://doi.org/10.1007/s00421-021-04680-x, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56708
Llewellyn, S., Conway, G., Zanoni, I., Jørgensen, A., Shah, U., Seleci, D., Keller, J., Kim, J., Wohlleben, W., Jensen, K., Costa, A., Jenkins, G., Clift, M., & Doak, S. (2021). Understanding the impact of more realistic low-dose, prolonged engineered nanomaterial exposure on genotoxicity using 3D models of the human liver. Journal of Nanobiotechnology, 19(1)
https://doi.org/10.1186/s12951-021-00938-w, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa57237
Llewellyn, S., Niemeijer, M., Nymark, P., Moné, M., Water, B., Conway, G., Jenkins, G., & Doak, S. (2021). In Vitro Three‐Dimensional Liver Models for Nanomaterial DNA Damage Assessment. Small, 17(15), 2006055
https://doi.org/10.1002/smll.202006055, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56073
Conway, G., Zizyte, D., Mondala, J., He, Z., Lynam, L., Lecourt, M., Barcia, C., Howe, O., & Curtin, J. (2021). Ursolic Acid Inhibits Collective Cell Migration and Promotes JNK-Dependent Lysosomal Associated Cell Death in Glioblastoma Multiforme Cells. Pharmaceuticals, 14(2), 91
https://doi.org/10.3390/ph14020091, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa65440
Conway, G., Shah, U., Llewellyn, S., Cervena, T., Evans, S., Al-Ali, A., Jenkins, G., Clift, M., & Doak, S. (2020). Adaptation of the in vitro micronucleus assay for genotoxicity testing using 3D liver models supporting longer-term exposure durations. Mutagenesis, 35(4), 319-329.
https://doi.org/10.1093/mutage/geaa018, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa54991
Llewellyn, S., Conway, G., Shah, U., Evans, S., Jenkins, G., Clift, M., & Doak, S. (2020). Advanced 3D Liver Models for In vitro Genotoxicity Testing Following Long-Term Nanomaterial Exposure. Journal of Visualized Experiments(160)
https://doi.org/10.3791/61141, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa54416
Conway, G., Heffernan, S., Horner, K., De Vito, G., & Conway, G. (2019). The Role of Mineral and Trace Element Supplementation in Exercise and Athletic Performance: A Systematic Review. Nutrients, 11(3), 696
https://doi.org/10.3390/nu11030696, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa51435
Conway, G., He, Z., Hutanu, A., Cribaro, G., Manaloto, E., Casey, A., Traynor, D., Milosavljevic, V., Howe, O., Barcia, C., Murray, J., Cullen, P., & Curtin, J. (2019). Cold Atmospheric Plasma induces accumulation of lysosomes and caspase-independent cell death in U373MG glioblastoma multiforme cells. Scientific Reports, 9(1)
https://doi.org/10.1038/s41598-019-49013-3, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa55404
He, Z., Liu, K., Manaloto, E., Casey, A., Cribaro, G., Byrne, H., Tian, F., Barcia, C., Conway, G., Cullen, P., & Curtin, J. (2018). Cold Atmospheric Plasma Induces ATP-Dependent Endocytosis of Nanoparticles and Synergistic U373MG Cancer Cell Death. Scientific Reports, 8(1)
https://doi.org/10.1038/s41598-018-23262-0, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa51508
Conway, G., Casey, A., Milosavljevic, V., Liu, Y., Howe, O., Cullen, P., & Curtin, J. (2016). Non-thermal atmospheric plasma induces ROS-independent cell death in U373MG glioma cells and augments the cytotoxicity of temozolomide. British Journal of Cancer, 114(4), 435-443.
https://doi.org/10.1038/bjc.2016.12, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa55405

Book Chapters

Heffernan, S. & Conway, G. (2021). Nutraceutical Alternatives to Pharmaceutical Analgesics in Osteoarthritis. Pain Management - Practices, Novel Therapies and Bioactives IntechOpen
https://doi.org/10.5772/intechopen.95919, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa65436

Taught Modules

PM-M28 Nano(geno)toxicology

The field of nanotechnology is ever increasing in size, and the number of nano-sized (1-100nm) particles being produced on a daily basis is at the tonnage level. Although nanotechnology-based applications are considered to be advantageous for a plethora of human activities, the potential risks posed by human exposure to nanoparticles is a constantly developing field of research. The purpose of this module therefore is to introduce to the student to particle toxicology and how it can impact upon human health. Further to this, the students will undertake a specific practical component to complement that of the theoretical content of the module. To this extent, the students will undertake a week-long, 'mini-project', covering the major areas of nanoparticle toxicology. From this approach, it is intended that the student will experience the key practical approaches taken in the field.
PMLM22 Laboratory Measurement Techniques for Medical Sciences

This module will enable students to understand the basic and advanced concepts of laboratory and measurement techniques used in medical sciences, how they may be applied with relevant methods of detection, gain `hands on¿ problem solving experience and strategic method development for complete bioanalysis according to target molecule characteristics and method application.

Dr Gill Conway

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