Dr James Murray

Senior Lecturer

Biomedical Sciences

j.t.murray@swansea.ac.uk

Research Office - 214
Second Floor
Institute of Life Science 1
Singleton Campus

Available For Postgraduate Supervision

Research Links

https://orcid.org/0000-0002-6928-2347

ResearchGate

Google Scholar

Scopus

About

Dr James Murray is a Senior Lecturer in ageing and ageing-related diseases. With a background in molecular immunology and cell signalling his group investigates mechanisms of ageing and ageing-related pathologies using the African Turquoise Killifish (Nothobranchius furzeri) as a model.

Killifish have a naturally short life span of fewer than six months, and exhibit tissue degeneration, similar to humans, and uniquely for vertebrate models are neurodegenerative. Killifish are also gene editable, and possess additional qualities that set them apart as a model for ageing research.

Areas Of Expertise

Biochemistry
Molecular immunology/virology
Cell biology
Autophagy
Cell signalling
Protein/lipid kinases
Drug discovery and target validation

Career Highlights

Teaching Interests

Biochemistry, molecular and cell biology. Ageing mechanisms, cell signalling, enzyme regulation and drug discovery.

Research

Publications

Research Highlights

McCaig, C., Ataliotis, P., Shtaya, A., Omar, A., Green, A., Kind, C., Pereira, A., Naray-Fejes-Toth, A., Fejes-Toth, G., Yáñez-Muñoz, R., Murray, J., & Hainsworth, A. (2019). Induction of the cell survival kinase Sgk1: A possible novel mechanism for α-phenyl-N-tert-butyl nitrone in experimental stroke. Journal of Cerebral Blood Flow & Metabolism, 39(6), 1111-1121.
https://doi.org/10.1177/0271678x17746980, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa58771
Rad, E., Murray, J., & Tee, A. (2018). Oncogenic Signalling through Mechanistic Target of Rapamycin (mTOR): A Driver of Metabolic Transformation and Cancer Progression. Cancers, 10(1), 5
https://doi.org/10.3390/cancers10010005, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa58770
Hodson, N., Dent, J., Song, Z., O'Leary, M., Nicholson, T., Jones, S., Murray, J., Jeromson, S., Hamilton, D., Breen, L., & Philp, A. (2020). Protein‐carbohydrate ingestion alters Vps34 cellular localization independent of changes in kinase activity in human skeletal muscle. Experimental Physiology, 105(12), 2178-2189.
https://doi.org/10.1113/ep088805, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa58769
Lawless, S., Kedia-Mehta, N., Walls, J., McGarrigle, R., Convery, O., Sinclair, L., Navarro, M., Murray, J., & Finlay, D. (2017). Glucose represses dendritic cell-induced T cell responses. Nature Communications, 8(1)
https://doi.org/10.1038/ncomms15620, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa54808
Dunlop, E., Seifan, S., Claessens, T., Behrends, C., Kamps, M., Rozycka, E., Kemp, A., Nookala, R., Blenis, J., Coull, B., Murray, J., Steensel, M., Wilkinson, S., & Tee, A. (2014). FLCN, a novel autophagy component, interacts with GABARAP and is regulated by ULK1 phosphorylation. Autophagy, 10(10), 1749-1760.
https://doi.org/10.4161/auto.29640, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa54809
Conway, G., He, Z., Hutanu, A., Cribaro, G., Manaloto, E., Casey, A., Traynor, D., Milosavljevic, V., Howe, O., Barcia, C., Murray, J., Cullen, P., & Curtin, J. (2019). Cold Atmospheric Plasma induces accumulation of lysosomes and caspase-independent cell death in U373MG glioblastoma multiforme cells. Scientific Reports, 9(1)
https://doi.org/10.1038/s41598-019-49013-3, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa55404
Murray, J. (2016). Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy, 12(1), 1-222.
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56401
D’Costa, Z., Higgins, C., Ong, C., Irwin, G., Boyle, D., McArt, D., McCloskey, K., Buckley, N., Crawford, N., Thiagarajan, L., Murray, J., Kennedy, R., Mulligan, K., Harkin, D., Waugh, D., Scott, C., Salto-Tellez, M., Williams, R., & Mullan, P. (2014). TBX2 represses CST6 resulting in uncontrolled legumain activity to sustain breast cancer proliferation: a novel cancer-selective target pathway with therapeutic opportunities.. Oncotarget, 5(6), 1609-1620.
https://doi.org/10.18632/oncotarget.1707, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56402
Huang, Y., Al-aidaroos, A., Yuen, H., Zhang, S., Shen, H., Rozycka, E., McCrudden, C., Tergaonkar, V., Gupta, A., Lin, Y., Thiery, J., Murray, J., & Zeng, Q. (2014). A role of autophagy in PTP4A3-driven cancer progression. Autophagy, 10(10), 1787-1800.
https://doi.org/10.4161/auto.29989, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56404
Matchett, K., McFarlane, S., Hamilton, S., Eltuhamy, Y., Davidson, M., Murray, J., Faheem, A., & El-Tanani, M. (2014). Ran GTPase in Nuclear Envelope Formation and Cancer Metastasis. Cancer Biology and the Nuclear Envelope (pp. 323-351). Springer New York
https://doi.org/10.1007/978-1-4899-8032-8_15, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56405
Murray, J. & Tee, A. (2018). Mechanistic Target of Rapamycin (mTOR) in the Cancer Setting. Cancers, 10(6), 168
https://doi.org/10.3390/cancers10060168, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56407
Chintapalli, R., Murray, M., & Murray, J. (2016). Heat Inactivation of Garlic (Allium sativum) Extract Abrogates Growth Inhibition of HeLa Cells. Nutrition and Cancer, 68(5), 818-826.
https://doi.org/10.1080/01635581.2016.1171885, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56408
Diez-Cecilia, E., Carson, R., Kelly, B., Schaeybroeck, S., Murray, J., & Rozas, I. (2015). Probing a 3,4′-bis-guanidinium diaryl derivative as an allosteric inhibitor of the Ras pathway. Bioorganic & Medicinal Chemistry Letters, 25(19), 4287-4292.
https://doi.org/10.1016/j.bmcl.2015.07.082, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56409
Rundqvist, H., Lilja, M., Rooyackers, O., Odrzywol, K., Murray, J., Esbjörnsson, M., & Jansson, E. (2013). Nutrient ingestion increased mTOR signaling, but not hVps34 activity in human skeletal muscle after sprint exercise. Physiological Reports, 1(5)
https://doi.org/10.1002/phy2.76, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56412
Sahin, P., McCaig, C., Jeevahan, J., Murray, J., & Hainsworth, A. (2013). The cell survival kinase SGK1 and its targets FOXO3a and NDRG1 in aged human brain. Neuropathology and Applied Neurobiology, 39(6), 623-633.
https://doi.org/10.1111/nan.12023, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56413
Pike, L., Singleton, D., Buffa, F., Abramczyk, O., Phadwal, K., Li, J., Simon, A., Murray, J., & Harris, A. (2012). Transcriptional up-regulation of ULK1 by ATF4 contributes to cancer cell survival. Biochemical Journal, 449(2), 389-400.
https://doi.org/10.1042/bj20120972, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56414
Yuen, H., Abramczyk, O., Montgomery, G., Chan, K., Huang, Y., Sasazuki, T., Shirasawa, S., Gopesh, S., Chan, K., Fennell, D., Janne, P., El-Tanani, M., & Murray, J. (2012). Impact of oncogenic driver mutations on feedback between the PI3K and MEK pathways in cancer cells. Bioscience Reports, 32(4), 413-422.
https://doi.org/10.1042/bsr20120050, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56415
Yuen, H., Chan, K., Grills, C., Murray, J., Platt-Higgins, A., Eldin, O., O'Byrne, K., Janne, P., Fennell, D., Johnston, P., Rudland, P., & El-Tanani, M. (2012). Ran Is a Potential Therapeutic Target for Cancer Cells with Molecular Changes Associated with Activation of the PI3K/Akt/mTORC1 and Ras/MEK/ERK Pathways. Clinical Cancer Research, 18(2), 380-391.
https://doi.org/10.1158/1078-0432.ccr-11-2035, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56416
McCaig, C., Potter, L., Abramczyk, O., & Murray, J. (2011). Phosphorylation of NDRG1 is temporally and spatially controlled during the cell cycle. Biochemical and Biophysical Research Communications, 411(2), 227-234.
https://doi.org/10.1016/j.bbrc.2011.06.092, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56417
McCoy, F., Hurwitz, J., McTavish, N., Paul, I., Barnes, C., O'Hagan, B., Odrzywol, K., Murray, J., Longley, D., McKerr, G., & Fennell, D. (2010). Obatoclax induces Atg7-dependent autophagy independent of beclin-1 and BAX/BAK. Cell Death & Disease, 1(12), e108-e108.
https://doi.org/10.1038/cddis.2010.86, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56418
Inglis, S., Gallacher, M., Brown, S., McTavish, N., Getty, J., Husband, E., Murray, J., & Wilson, S. (2009). SGK1 activity in Na+ absorbing airway epithelial cells monitored by assaying NDRG1-Thr346/356/366 phosphorylation. Pflügers Archiv - European Journal of Physiology, 457(6), 1287-1301.
https://doi.org/10.1007/s00424-008-0587-1, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56419
MacKenzie, M., Hamilton, D., Murray, J., Taylor, P., & Baar, K. (2009). mVps34 is activated following high-resistance contractions. The Journal of Physiology, 587(1), 253-260.
https://doi.org/10.1113/jphysiol.2008.159830, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56420
MacKenzie, M., Hamilton, D., Murray, J., & Baar, K. (2007). mVps34 is activated by an acute bout of resistance exercise. Biochemical Society Transactions, 35(5), 1314-1316.
https://doi.org/10.1042/bst0351314, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56421
Murray, J. & Backer, J. (2005). Analysis of hVps34/hVps15 Interactions with Rab5 In Vivo and In Vitro. Methods in Enzymology (pp. 789-799). Elsevier
https://doi.org/10.1016/s0076-6879(05)03068-5, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56422
Murray, J., Cummings, L., Bloomberg, G., & Cohen, P. (2005). Identification of different specificity requirements between SGK1 and PKBα. FEBS Letters, 579(5), 991-994.
https://doi.org/10.1016/j.febslet.2004.12.069, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56423
Rixon, H., Brown, G., Murray, J., & Sugrue, R. (2005). The respiratory syncytial virus small hydrophobic protein is phosphorylated via a mitogen-activated protein kinase p38-dependent tyrosine kinase activity during virus infection. Journal of General Virology, 86(2), 375-384.
https://doi.org/10.1099/vir.0.80563-0, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56424
Byfield, M., Murray, J., & Backer, J. (2005). hVps34 Is a Nutrient-regulated Lipid Kinase Required for Activation of p70 S6 Kinase. Journal of Biological Chemistry, 280(38), 33076-33082.
https://doi.org/10.1074/jbc.m507201200, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56426
Murray, J., CAMPBELL, D., MORRICE, N., AULD, G., SHPIRO, N., MARQUEZ, R., PEGGIE, M., BAIN, J., BLOOMBERG, G., GRAHAMMER, F., LANG, F., WULFF, P., KUHL, D., & COHEN, P. (2004). Exploitation of KESTREL to identify NDRG family members as physiological substrates for SGK1 and GSK3. Biochemical Journal, 384(3), 477-488.
https://doi.org/10.1042/bj20041057, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56427
Murray, J., CAMPBELL, D., PEGGIE, M., ALFONSO, M., & COHEN, P. (2004). Identification of filamin C as a new physiological substrate of PKBα using KESTREL. Biochemical Journal, 384(3), 489-494.
https://doi.org/10.1042/bj20041058, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56428
Murray, J., Panaretou, C., Stenmark, H., Miaczynska, M., & Backer, J. (2002). Role of Rab5 in the Recruitment of hVps34/p150 to the Early Endosome. Traffic, 3(6), 416-427.
https://doi.org/10.1034/j.1600-0854.2002.30605.x, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56429
Lu, Z., Murray, J., Luo, W., Li, H., Wu, X., Xu, H., Backer, J., & Chen, Y. (2002). Transforming Growth Factor β Activates Smad2 in the Absence of Receptor Endocytosis. Journal of Biological Chemistry, 277(33), 29363-29368.
https://doi.org/10.1074/jbc.m203495200, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56430
Murray, J., Craggs, G., Wilson, L., & Kellie, S. (2000). Mechanism of phosphatidylinositol 3-kinase-dependent increases in BAC1.2F5 macrophage-like cell density in response to M-CSF: Phosphatidylinositol 3-kinase inhibitors increase the rate of apoptosis rather than inhibit DNA synthesis. Inflammation Research, 49(11), 610-618.
https://doi.org/10.1007/s000110050638, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56431
Murray, J., Wilson, L., & Kellie, S. (2000). Phosphatidylinositol-3' kinase-dependent vesicle formation in macrophages in response to macrophage colony stimulating factor. Journal of Cell Science, 113(2), 337-348.
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56432
https://jcs.biologists.org/content/113/2/337
Welti, S., Condeelis, J., Segall, J., Hill, K., Yu, J., Murray, J., Yip, S., & Backer, J. (2000). Specific Requirement for the p85-p110α Phosphatidylinositol 3-Kinase during Epidermal Growth Factor-stimulated Actin Nucleation in Breast Cancer Cells. Journal of Biological Chemistry, 275(6), 3741-3744.
https://doi.org/10.1074/jbc.275.6.3741, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56433
Lane, J., Korolchuk, V., & Murray, J. (2017). Signalling mechanisms in autophagy: an introduction to the issue. Essays in Biochemistry, 61(6), 561-563.
https://doi.org/10.1042/ebc20170116, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa58772
Wahid, M., Mackenzie, G., Rooney, L., Greig, J., McConnell, G., Combet, E., Gray, S., Murray, J., Currie, S., Gould, G., & Cunningham, M. (2024). From freeze to function: optimised cryopreservation and mitochondrial analysis workflow for skeletal muscle biopsies. BMC Methods, 1, 16
https://doi.org/10.1186/s44330-024-00017-0, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa68448

All Research

Journal Articles

Wahid, M., Mackenzie, G., Rooney, L., Greig, J., McConnell, G., Combet, E., Gray, S., Murray, J., Currie, S., Gould, G., & Cunningham, M. (2024). From freeze to function: optimised cryopreservation and mitochondrial analysis workflow for skeletal muscle biopsies. BMC Methods, 1, 16
https://doi.org/10.1186/s44330-024-00017-0, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa68448
Hodson, N., Dent, J., Song, Z., O'Leary, M., Nicholson, T., Jones, S., Murray, J., Jeromson, S., Hamilton, D., Breen, L., & Philp, A. (2020). Protein‐carbohydrate ingestion alters Vps34 cellular localization independent of changes in kinase activity in human skeletal muscle. Experimental Physiology, 105(12), 2178-2189.
https://doi.org/10.1113/ep088805, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa58769
Conway, G., He, Z., Hutanu, A., Cribaro, G., Manaloto, E., Casey, A., Traynor, D., Milosavljevic, V., Howe, O., Barcia, C., Murray, J., Cullen, P., & Curtin, J. (2019). Cold Atmospheric Plasma induces accumulation of lysosomes and caspase-independent cell death in U373MG glioblastoma multiforme cells. Scientific Reports, 9(1)
https://doi.org/10.1038/s41598-019-49013-3, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa55404
McCaig, C., Ataliotis, P., Shtaya, A., Omar, A., Green, A., Kind, C., Pereira, A., Naray-Fejes-Toth, A., Fejes-Toth, G., Yáñez-Muñoz, R., Murray, J., & Hainsworth, A. (2019). Induction of the cell survival kinase Sgk1: A possible novel mechanism for α-phenyl-N-tert-butyl nitrone in experimental stroke. Journal of Cerebral Blood Flow & Metabolism, 39(6), 1111-1121.
https://doi.org/10.1177/0271678x17746980, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa58771
Murray, J. & Tee, A. (2018). Mechanistic Target of Rapamycin (mTOR) in the Cancer Setting. Cancers, 10(6), 168
https://doi.org/10.3390/cancers10060168, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56407
Rad, E., Murray, J., & Tee, A. (2018). Oncogenic Signalling through Mechanistic Target of Rapamycin (mTOR): A Driver of Metabolic Transformation and Cancer Progression. Cancers, 10(1), 5
https://doi.org/10.3390/cancers10010005, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa58770
Lane, J., Korolchuk, V., & Murray, J. (2017). Signalling mechanisms in autophagy: an introduction to the issue. Essays in Biochemistry, 61(6), 561-563.
https://doi.org/10.1042/ebc20170116, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa58772
Lawless, S., Kedia-Mehta, N., Walls, J., McGarrigle, R., Convery, O., Sinclair, L., Navarro, M., Murray, J., & Finlay, D. (2017). Glucose represses dendritic cell-induced T cell responses. Nature Communications, 8(1)
https://doi.org/10.1038/ncomms15620, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa54808
Chintapalli, R., Murray, M., & Murray, J. (2016). Heat Inactivation of Garlic (Allium sativum) Extract Abrogates Growth Inhibition of HeLa Cells. Nutrition and Cancer, 68(5), 818-826.
https://doi.org/10.1080/01635581.2016.1171885, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56408
Murray, J. (2016). Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy, 12(1), 1-222.
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56401
Diez-Cecilia, E., Carson, R., Kelly, B., Schaeybroeck, S., Murray, J., & Rozas, I. (2015). Probing a 3,4′-bis-guanidinium diaryl derivative as an allosteric inhibitor of the Ras pathway. Bioorganic & Medicinal Chemistry Letters, 25(19), 4287-4292.
https://doi.org/10.1016/j.bmcl.2015.07.082, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56409
Dunlop, E., Seifan, S., Claessens, T., Behrends, C., Kamps, M., Rozycka, E., Kemp, A., Nookala, R., Blenis, J., Coull, B., Murray, J., Steensel, M., Wilkinson, S., & Tee, A. (2014). FLCN, a novel autophagy component, interacts with GABARAP and is regulated by ULK1 phosphorylation. Autophagy, 10(10), 1749-1760.
https://doi.org/10.4161/auto.29640, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa54809
Huang, Y., Al-aidaroos, A., Yuen, H., Zhang, S., Shen, H., Rozycka, E., McCrudden, C., Tergaonkar, V., Gupta, A., Lin, Y., Thiery, J., Murray, J., & Zeng, Q. (2014). A role of autophagy in PTP4A3-driven cancer progression. Autophagy, 10(10), 1787-1800.
https://doi.org/10.4161/auto.29989, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56404
D’Costa, Z., Higgins, C., Ong, C., Irwin, G., Boyle, D., McArt, D., McCloskey, K., Buckley, N., Crawford, N., Thiagarajan, L., Murray, J., Kennedy, R., Mulligan, K., Harkin, D., Waugh, D., Scott, C., Salto-Tellez, M., Williams, R., & Mullan, P. (2014). TBX2 represses CST6 resulting in uncontrolled legumain activity to sustain breast cancer proliferation: a novel cancer-selective target pathway with therapeutic opportunities.. Oncotarget, 5(6), 1609-1620.
https://doi.org/10.18632/oncotarget.1707, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56402
Rundqvist, H., Lilja, M., Rooyackers, O., Odrzywol, K., Murray, J., Esbjörnsson, M., & Jansson, E. (2013). Nutrient ingestion increased mTOR signaling, but not hVps34 activity in human skeletal muscle after sprint exercise. Physiological Reports, 1(5)
https://doi.org/10.1002/phy2.76, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56412
Sahin, P., McCaig, C., Jeevahan, J., Murray, J., & Hainsworth, A. (2013). The cell survival kinase SGK1 and its targets FOXO3a and NDRG1 in aged human brain. Neuropathology and Applied Neurobiology, 39(6), 623-633.
https://doi.org/10.1111/nan.12023, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56413
Pike, L., Singleton, D., Buffa, F., Abramczyk, O., Phadwal, K., Li, J., Simon, A., Murray, J., & Harris, A. (2012). Transcriptional up-regulation of ULK1 by ATF4 contributes to cancer cell survival. Biochemical Journal, 449(2), 389-400.
https://doi.org/10.1042/bj20120972, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56414
Yuen, H., Abramczyk, O., Montgomery, G., Chan, K., Huang, Y., Sasazuki, T., Shirasawa, S., Gopesh, S., Chan, K., Fennell, D., Janne, P., El-Tanani, M., & Murray, J. (2012). Impact of oncogenic driver mutations on feedback between the PI3K and MEK pathways in cancer cells. Bioscience Reports, 32(4), 413-422.
https://doi.org/10.1042/bsr20120050, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56415
Yuen, H., Chan, K., Grills, C., Murray, J., Platt-Higgins, A., Eldin, O., O'Byrne, K., Janne, P., Fennell, D., Johnston, P., Rudland, P., & El-Tanani, M. (2012). Ran Is a Potential Therapeutic Target for Cancer Cells with Molecular Changes Associated with Activation of the PI3K/Akt/mTORC1 and Ras/MEK/ERK Pathways. Clinical Cancer Research, 18(2), 380-391.
https://doi.org/10.1158/1078-0432.ccr-11-2035, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56416
McCaig, C., Potter, L., Abramczyk, O., & Murray, J. (2011). Phosphorylation of NDRG1 is temporally and spatially controlled during the cell cycle. Biochemical and Biophysical Research Communications, 411(2), 227-234.
https://doi.org/10.1016/j.bbrc.2011.06.092, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56417
McCoy, F., Hurwitz, J., McTavish, N., Paul, I., Barnes, C., O'Hagan, B., Odrzywol, K., Murray, J., Longley, D., McKerr, G., & Fennell, D. (2010). Obatoclax induces Atg7-dependent autophagy independent of beclin-1 and BAX/BAK. Cell Death & Disease, 1(12), e108-e108.
https://doi.org/10.1038/cddis.2010.86, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56418
Inglis, S., Gallacher, M., Brown, S., McTavish, N., Getty, J., Husband, E., Murray, J., & Wilson, S. (2009). SGK1 activity in Na+ absorbing airway epithelial cells monitored by assaying NDRG1-Thr346/356/366 phosphorylation. Pflügers Archiv - European Journal of Physiology, 457(6), 1287-1301.
https://doi.org/10.1007/s00424-008-0587-1, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56419
MacKenzie, M., Hamilton, D., Murray, J., Taylor, P., & Baar, K. (2009). mVps34 is activated following high-resistance contractions. The Journal of Physiology, 587(1), 253-260.
https://doi.org/10.1113/jphysiol.2008.159830, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56420
MacKenzie, M., Hamilton, D., Murray, J., & Baar, K. (2007). mVps34 is activated by an acute bout of resistance exercise. Biochemical Society Transactions, 35(5), 1314-1316.
https://doi.org/10.1042/bst0351314, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56421
Byfield, M., Murray, J., & Backer, J. (2005). hVps34 Is a Nutrient-regulated Lipid Kinase Required for Activation of p70 S6 Kinase. Journal of Biological Chemistry, 280(38), 33076-33082.
https://doi.org/10.1074/jbc.m507201200, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56426
Murray, J., Cummings, L., Bloomberg, G., & Cohen, P. (2005). Identification of different specificity requirements between SGK1 and PKBα. FEBS Letters, 579(5), 991-994.
https://doi.org/10.1016/j.febslet.2004.12.069, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56423
Rixon, H., Brown, G., Murray, J., & Sugrue, R. (2005). The respiratory syncytial virus small hydrophobic protein is phosphorylated via a mitogen-activated protein kinase p38-dependent tyrosine kinase activity during virus infection. Journal of General Virology, 86(2), 375-384.
https://doi.org/10.1099/vir.0.80563-0, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56424
Murray, J., CAMPBELL, D., PEGGIE, M., ALFONSO, M., & COHEN, P. (2004). Identification of filamin C as a new physiological substrate of PKBα using KESTREL. Biochemical Journal, 384(3), 489-494.
https://doi.org/10.1042/bj20041058, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56428
Murray, J., CAMPBELL, D., MORRICE, N., AULD, G., SHPIRO, N., MARQUEZ, R., PEGGIE, M., BAIN, J., BLOOMBERG, G., GRAHAMMER, F., LANG, F., WULFF, P., KUHL, D., & COHEN, P. (2004). Exploitation of KESTREL to identify NDRG family members as physiological substrates for SGK1 and GSK3. Biochemical Journal, 384(3), 477-488.
https://doi.org/10.1042/bj20041057, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56427
Lu, Z., Murray, J., Luo, W., Li, H., Wu, X., Xu, H., Backer, J., & Chen, Y. (2002). Transforming Growth Factor β Activates Smad2 in the Absence of Receptor Endocytosis. Journal of Biological Chemistry, 277(33), 29363-29368.
https://doi.org/10.1074/jbc.m203495200, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56430
Murray, J., Panaretou, C., Stenmark, H., Miaczynska, M., & Backer, J. (2002). Role of Rab5 in the Recruitment of hVps34/p150 to the Early Endosome. Traffic, 3(6), 416-427.
https://doi.org/10.1034/j.1600-0854.2002.30605.x, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56429
Murray, J., Craggs, G., Wilson, L., & Kellie, S. (2000). Mechanism of phosphatidylinositol 3-kinase-dependent increases in BAC1.2F5 macrophage-like cell density in response to M-CSF: Phosphatidylinositol 3-kinase inhibitors increase the rate of apoptosis rather than inhibit DNA synthesis. Inflammation Research, 49(11), 610-618.
https://doi.org/10.1007/s000110050638, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56431
Welti, S., Condeelis, J., Segall, J., Hill, K., Yu, J., Murray, J., Yip, S., & Backer, J. (2000). Specific Requirement for the p85-p110α Phosphatidylinositol 3-Kinase during Epidermal Growth Factor-stimulated Actin Nucleation in Breast Cancer Cells. Journal of Biological Chemistry, 275(6), 3741-3744.
https://doi.org/10.1074/jbc.275.6.3741, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56433
Murray, J., Wilson, L., & Kellie, S. (2000). Phosphatidylinositol-3' kinase-dependent vesicle formation in macrophages in response to macrophage colony stimulating factor. Journal of Cell Science, 113(2), 337-348.
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56432
https://jcs.biologists.org/content/113/2/337

Book Chapters

Matchett, K., McFarlane, S., Hamilton, S., Eltuhamy, Y., Davidson, M., Murray, J., Faheem, A., & El-Tanani, M. (2014). Ran GTPase in Nuclear Envelope Formation and Cancer Metastasis. Cancer Biology and the Nuclear Envelope (pp. 323-351). Springer New York
https://doi.org/10.1007/978-1-4899-8032-8_15, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56405
Murray, J. & Backer, J. (2005). Analysis of hVps34/hVps15 Interactions with Rab5 In Vivo and In Vitro. Methods in Enzymology (pp. 789-799). Elsevier
https://doi.org/10.1016/s0076-6879(05)03068-5, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56422

Supervision

Enhanced Osteogenesis by Combing Exogenous BMPs with Hydroxyapatite/Calcium Carbonate Bone Grafts: In Vitro and In Vivo Study (awarded 2025)

MD

Other supervisor: Prof Venkat Kanamarlapudi
Dissecting the fundamental mechanisms of ageing using the African Turquoise Killifish (current)

PhD

Other supervisor: Dr Emma Kenyon
RNA-seq of skeletal muscle, to look at changes in gene expression across life course in Nothobranchius furzeri (current)

MSc

Other supervisor: Dr Matthew Hitchings

Taught Modules

PM-130 Fundamental Research Skills

This module is designed to develop the skills required for students of biochemistry and genetics degree programmes. Students meet with their tutors and will be given a series of assignments designed to develop skills in key areas such as essay writing, presentations and general numeracy.
PM-277 Techniques in Molecular Biology

The module will provide a sound theoretical basis to a comprehensive range of biomolecular techniques currently employed in molecular genetics and biochemistry. Particular emphasis is placed on DNA recombinant technology, next generation sequencing, transcriptomics, proteomics and mass spectrometry.
PM-277C Technegau Bioleg Foleciwlaidd

Bydd y modiwl yn darparu sylfaen ddamcaniaethol gadarn ar gyfer ystod gynhwysfawr o dechnegau biofoleciwlaidd a ddefnyddir ar hyn o bryd mewn geneteg foleciwlaidd a biocemeg. Rhoddir pwyslais arbennig ar dechnoleg ail-gyfuno DNA, dilyniannu¿r genhedlaeth nesaf, trawsgrifiadomeg, proteinomeg a sbectrometreg màs.
PM-280 Skills for Researchers

The modern scientist graduate is expected to have gained extensive laboratory-based experience and this is certainly essential for any student intent on pursuing a research-based career. Skills for Researchers provides students with the opportunity to acquire the core skills to be able to conduct, analyse, interpret and present scientific experiments. A proportion of the module will be spent in the laboratory gaining hands-on experience. Skills acquired in this module will form the basis for future experimental work, including the final year project. Students will have the opportunity to provide feedback to peers and engage with a variety of online learning materials.
PM-300 Medical Genetics

The course is designed to provide an advanced study of the identification of human genes and the determination of the influence of human genes upon disease and health status. Gene identification provides targets for the development of new pharmaceuticals and the range of variation present in the population.
PM-344 Capstone Project

The aim of this module is to provide a capstone experience to students¿ learning, through participating in their own enquiry-based research project, with guidance from an academic supervisor. The project may be laboratory or non-laboratory based, but it will always involve a research question that is drawn from the literature, and focused on a topic relevant to the life sciences. It will ask a research question and involve the critical analysis of research findings. Students will refine their oral and written communication skills to a graduate level through an oral presentation and dissertation on their research findings and conclusions.
PM-384 The biology of ageing in health and disease

The course is designed to provide an advanced study of the underlying principles of human ageing. It will begin with the impact of ageing on health care at a societal level, then will focus on ageing at individual levels, through to the molecular basis of ageing and ageing-related diseases, and end with the future potential of interventions that modify human ageing.
PMGM17 Post Graduate Taught Masters Dissertation

The module is for students to build on their previous knowledge, skills and experience by undertaking a laboratory based or suitable non-laboratory based project on a specific subject related to genomics.
PMNM17 Neurodegeneration & Repair

This MSc Medical Neuroscience module will study the processes involved in brain degeneration and repair. We will review disease pathology and diagnosis, the cellular and molecular basis of disease, and possible new therapies aimed at restoring brain function, including cell replacement strategies. Content will involve lectures, tutorials, expert guest seminars and workshops.

Dr James Murray

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Book Chapters

Supervision

Enhanced Osteogenesis by Combing Exogenous BMPs with Hydroxyapatite/Calcium Carbonate Bone Grafts: In Vitro and In Vivo Study (awarded 2025)

Dissecting the fundamental mechanisms of ageing using the African Turquoise Killifish (current)

RNA-seq of skeletal muscle, to look at changes in gene expression across life course in Nothobranchius furzeri (current)

Taught Modules

PM-130 Fundamental Research Skills

PM-277 Techniques in Molecular Biology

PM-277C Technegau Bioleg Foleciwlaidd

PM-280 Skills for Researchers

PM-300 Medical Genetics

PM-344 Capstone Project

PM-384 The biology of ageing in health and disease

PMGM17 Post Graduate Taught Masters Dissertation

PMNM17 Neurodegeneration & Repair