Dr Rod Middleton

Associate Professor Disease Registers & Data Research

Health Data Science

+44 (0) 1792 606760

r.m.middleton@swansea.ac.uk

Cellular Office - 204
Second Floor
Data Science Building
Singleton Campus

Research Links

https://orcid.org/0000-0002-2130-4420

ResearchGate

About

Rod Middleton is Associate Professor, Disease Registers & Data Research in Health Data Science at Swansea.

Rod is Principal Investigator of the United Kingdom MS Register, a nationwide initiative to capture ‘Real world’ data for and about people with Multiple Sclerosis. He has additionally been PI for a number of COVID and Patient reported outcome initiatives across the health data science portfolio. Amongst these are PROMIS, NeurOMS and the Registry Collaboration Network in Secondary Progressive MS.

Rod has a passionate interest in putting patients and participants at the centre of research and is a firm believer that people are the best narrators of their own conditions.

Areas Of Expertise

Health Informatics
Disease Registers
Epidemiology
Cognition and Cognitive instruments
Data Linkage
Patient Reported Outcome Measures
System Architecture
Project Management

Career Highlights

Teaching Interests

Teach on PMIM201 : Implementation of Electronic Health Records
Teach on PMIM201 : New Technologies in Healthcare
Teach on PMIM603 : Leadership in project management
Marker and moderator for PMIM201 clinical coding presentations Supervision

Research Award Highlights Collaborations

Publications

Research Highlights

Das, J., Rog, D., Middleton, R., Rodgers, J., & Nicholas, R. (2024). University education facilitates uptake of disease-modifying therapies for multiple sclerosis: A community-based study using the UK MS Register. Multiple Sclerosis Journal, 30(2), 192-199.
https://doi.org/10.1177/13524585231221411, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa68040
http://dx.doi.org/10.1177/13524585231221411
Giovannoni, G., Ford, H., Schmierer, K., Middleton, R., Stennett, A., Pomeroy, I., Fisniku, L., Scalfari, A., Bannon, C., Stross, R., Hughes, S., Williams, A., Josephs, S., Peel, C., & Straukiene, A. (n.d.) MS care: integrating advanced therapies and holistic management. Frontiers in Neurology, 14
https://doi.org/10.3389/fneur.2023.1286122, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa68039
http://dx.doi.org/10.3389/fneur.2023.1286122
Rad, E., Saboori, S., Tektonidis, T., Simpson-Yap, S., Reece, J., Hebert, J., Nicholas, R., Middleton, R., Tammam, J., Black, L., & Coe, S. (2024). A systematic review and meta-analysis of Dietary Inflammatory Index and the likelihood of multiple sclerosis/ demyelinating autoimmune disease. Clinical Nutrition ESPEN, 62, 108-114.
https://doi.org/10.1016/j.clnesp.2024.04.022, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa68038
http://dx.doi.org/10.1016/j.clnesp.2024.04.022
Thomason, S., Moghaddam, N., Evangelou, N., Middleton, R., & Nair, R. (2024). Barriers and strategies to medication adherence amongst people with multiple sclerosis and cognitive problems. Multiple Sclerosis and Related Disorders, 88, 105727
https://doi.org/10.1016/j.msard.2024.105727, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa68037
http://dx.doi.org/10.1016/j.msard.2024.105727
Zaratin, P., Samadzadeh, S., Seferoğlu, M., Ricigliano, V., Silva, J., Tunc, A., Brichetto, G., Coetzee, T., Helme, A., Khan, U., McBurney, R., Peryer, G., Weiland, H., Baneke, P., Battaglia, M., Block, V., Capezzuto, L., Carment, L., Cortesi, P...., & Vermersch, P. (n.d.) The global patient-reported outcomes for multiple sclerosis initiative: bridging the gap between clinical research and care – updates at the 2023 plenary event. Frontiers in Neurology, 15
https://doi.org/10.3389/fneur.2024.1407257, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa68036
http://dx.doi.org/10.3389/fneur.2024.1407257
Middleton, R., Allen-Philby, K., Schmierer, K., Espasandin, M., C.Roberts, ., Nicholas, R., Rodgers, J., Lockhart-Jones, H., Tuite-Dalton, K., & Ford, D. (2019). 175 A model for participant engagement in research: the MS register. In Journal of Neurology, Neurosurgery and Psychiatry (pp. e46BMJ.
https://doi.org/10.1136/jnnp-2019-ABN-2.155, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61927
https://jnnp.bmj.com/content/90/12/e46.3.info
Middleton, R., Craig, E., Rodgers, W., Tuite-Dalton, K., Garjani, A., Evangelou, N., Hunter, R., DasNair, R., & Nicholas, R. (2022). 096 COVID-19 in MS: clinically reported outcomes from the UK MS register. In Journal of Neurology, Neurosurgery and Psychiatry (pp. A130.3-A130). BMJ.
https://doi.org/10.1136/jnnp-2022-abn.421, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa62044
Garjani, A., Middleton, R., Law, G., Tuite-Dalton, K., Hunter, R., Nair, R., Evangelou, N., & Nicholas, R. (2022). COVID-19 and multiple sclerosis: An updated report of the community-based longitudinal UK MS Register study. Journal of Neurology, Neurosurgery and Psychiatry, 93(6), A93.2-A93.
https://doi.org/10.1136/jnnp-2022-abn.302, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa62047
Knowles, S., Middleton, R., Cooze, B., Farkas, I., Leung, Y., Allen, K., WINSLADE, M., Owen, D., Magliozzi, R., Reynolds, R., Neal, J., Pearson, O., Nicholas, R., Pickrell, O., Howell, O., & Group), . (2024). Comparing the Pathology, Clinical, and Demographic Characteristics of Younger and Older‐Onset Multiple Sclerosis. Annals of Neurology, 95(3), 471-486.
https://doi.org/10.1002/ana.26843, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa65353
http://dx.doi.org/10.1002/ana.26843
Nair, R., Hunter, R., Garjani, A., Middleton, R., Tuite-Dalton, K., Nicholas, R., & Evangelou, N. (2021). Challenges of developing, conducting, analysing and reporting a COVID-19 study as the COVID-19 pandemic unfolds: an online co-autoethnographic study. BMJ Open, 11(6), e048788
https://doi.org/10.1136/bmjopen-2021-048788, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa65365
http://dx.doi.org/10.1136/bmjopen-2021-048788
Lerede, A., Rodgers, J., Middleton, R., Hampshire, A., Nicholas, R., Coles, A., Chataway, J., Duddy, M., Emsley, H., Ford, H., Fisniku, L., Galea, I., Harrower, T., Hobart, J., Huseyin, H., Kipps, C., Marta, M., McDonnell, G., McLean, B...., & Group), . (2023). Patient-reported outcomes in multiple sclerosis: a prospective registry cohort study. Brain Communications, 5(4)
https://doi.org/10.1093/braincomms/fcad199, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa66407
Nicholas, R., Rodgers, J., Witts, J., Lerede, A., Friede, T., Hillert, J., Forsberg, L., Glaser, A., Manouchehrinia, A., Ramanujam, R., Spelman, T., Klyve, P., Drahota, J., Horakova, D., Joensen, H., Pontieri, L., Magyari, M., Ellenberger, D., Stahmann, A...., & Middleton, R. (2023). The impact of healthcare systems on the clinical diagnosis and disease-modifying treatment usage in relapse-onset multiple sclerosis: a real-world perspective in five registries across Europe. Therapeutic Advances in Neurological Disorders, 16
https://doi.org/10.1177/17562864231198963, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa66408
Nicholas, R., Tallantyre, E., Witts, J., Marrie, R., Craig, E., Knowles, S., Pearson, O., Harding, K., Kreft, K., Hawken, J., Ingram, G., Morgan, B., Middleton, R., Robertson, N., & Group, U. (2024). Algorithmic approach to finding people with multiple sclerosis using routine healthcare data in Wales. Journal of Neurology, Neurosurgery and Psychiatry, 95(11), 1032-1035.
https://doi.org/10.1136/jnnp-2024-333532, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa66529
Lacey, A., Lyons, J., Akbari, A., Turner, S., Walters, A., Fonferko-Shadrach, B., Pickrell, O., Rees, M., Lyons, R., Ford, D., & Middleton, R. (2017). Codifying unstructured data: A Natural Language Processing approach to extract rich data from clinical letters. International Journal for Population Data Science, 1(1)
https://doi.org/10.23889/ijpds.v1i1.354, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa39437
Middleton, R., Rodgers, J., Giovannoni, G., Schmierer, K., Dobson, R., Allen-Philbey, K., Patterson, A., Tuite-Dalton, K., Ford, D., & Akbari, A. (2017). A Comparison of participant supplied EDSS scores and clinically submitted data via the UK MS Register. Multiple Sclerosis Journal, 23(3_suppl), 85-426.
https://doi.org/10.1177/1352458517731404, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa39440
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000413730200236&KeyUID=WOS:000413730200236
Middleton, R., Ford, D., Akbari, A., Lockhart-Jones, H., Jones, J., Hughes, S., & Owen, C. (2016). Natural language processing to capture MS clinical data. Multiple Sclerosis Journal, 22(3_suppl), 717-717.
https://doi.org/10.1177/1352458516663067, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa44549
Coe, S., Tektonidis, T., Coverdale, C., Penny, S., Collett, J., Chu, B., Izadi, H., Middleton, R., & Dawes, H. (2021). A cross sectional assessment of nutrient intake and the association of the inflammatory properties of nutrients and foods with symptom severity in a large cohort from the UK Multiple Sclerosis Registry. Nutrition Research, 85, 31-39.
https://doi.org/10.1016/j.nutres.2020.11.006, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61488
Vickaryous, N., Jitlal, M., Jacobs, B., Middleton, R., Chandran, S., MacDougall, N., Giovannoni, G., & Dobson, R. (2020). Remote testing of vitamin D levels across the UK MS population—A case control study. PLOS ONE, 15(12), e0241459
https://doi.org/10.1371/journal.pone.0241459, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61487
Ellenberger, D., Parciak, T., Brola, W., Hillert, J., Middleton, R., Stahmann, A., Thalheim, C., & Flachenecker, P. (2022). Comparison of employment among people with Multiple Sclerosis across Europe. Multiple Sclerosis Journal - Experimental, Translational and Clinical, 8(2), 205521732210906
https://doi.org/10.1177/20552173221090653, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61486
Kamudoni, P., Amtmann, D., Johns, J., Cook, K., Salem, R., Salek, S., Raab, J., Middleton, R., Repovic, P., Alschuler, K., Geldern, G., Wundes, A., Barrett, A., Olayinka-Amao, O., & Henke, C. (2022). The validity, responsiveness, and score interpretation of the PROMISnq Physical Function – Multiple Sclerosis 15a short form in multiple sclerosis. Multiple Sclerosis and Related Disorders, 62, 103753
https://doi.org/10.1016/j.msard.2022.103753, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61485
Moore, H., Nair, K., Baster, K., Middleton, R., Paling, D., & Sharrack, B. (2022). Fatigue in multiple sclerosis: A UK MS-register based study. Multiple Sclerosis and Related Disorders, 64, 103954
https://doi.org/10.1016/j.msard.2022.103954, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61484
Kamudoni, P., Johns, J., Cook, K., Salem, R., Salek, S., Raab, J., Middleton, R., Henke, C., & Amtmann, D. (2022). A comparison of the measurement properties of the PROMIS Fatigue (MS) 8a against legacy fatigue questionnaires. Multiple Sclerosis and Related Disorders, 66, 104048
https://doi.org/10.1016/j.msard.2022.104048, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61483
Simpson-Yap, S., Pirmani, A., Brouwer, E., Peeters, L., Geys, L., Parciak, T., Helme, A., Hillert, J., Moreau, Y., Edan, G., Spelman, T., Sharmin, S., McBurney, R., Schmidt, H., Bergmann, A., Braune, S., Stahmann, A., Middleton, R., Salter, A...., & Kalincik, T. (2022). Severity of COVID19 infection among patients with multiple sclerosis treated with interferon-β. Multiple Sclerosis and Related Disorders, 66, 104072
https://doi.org/10.1016/j.msard.2022.104072, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61482
Meek, C., Nair, R., Evangelou, N., Middleton, R., Tuite-Dalton, K., & Moghaddam, N. (2022). Psychological flexibility, distress, and quality of life in secondary progressive multiple sclerosis: A cross-sectional study. Multiple Sclerosis and Related Disorders, 67, 104154
https://doi.org/10.1016/j.msard.2022.104154, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61481
Frahm, N., Fneish, F., Ellenberger, D., Haas, J., Loebermann, M., Parciak, T., Peters, M., Pöhlau, D., Rodgers, J., Röper, A., Schilling, S., Stahmann, A., Temmes, H., Zettl, U., & Middleton, R. (2022). SARS-CoV-2 vaccination in patients with multiple sclerosis in Germany and the United Kingdom: Gender-specific results from a longitudinal observational study. The Lancet Regional Health - Europe, 22, 100502
https://doi.org/10.1016/j.lanepe.2022.100502, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61480
Middleton, R., Balbuena, L., Middleton, R., Tuite-Dalton, K., Pouliou, T., Williams, K., & Noble, G. (2016). Sunshine, Sea, and Season of Birth: MS Incidence in Wales. PLOS ONE, 11(5), e0155181
https://doi.org/10.1371/journal.pone.0155181, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa29587
Middleton, R., Ford, D., Jones, K., Middleton, R., Lockhart-Jones, H., Maramba, I., Noble, G., Osborne, L., & Lyons, R. (2012). The feasibility of collecting information from people with Multiple Sclerosis for the UK MS Register via a web portal: characterising a cohort of people with MS. BMC Medical Informatics and Decision Making, 12(1), 73
https://doi.org/10.1186/1472-6947-12-73, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa11798
Middleton, R., Noble, J., Osborne, L., Jones, K., Middleton, R., Ford, D., Noble, G., Jones, K., & Ford, D. (2012). Commentary on 'Disability outcome measures in multiple sclerosis clinical trials'. Multiple Sclerosis Journal, 18(12), 1718-1720.
https://doi.org/10.1177/1352458512457847, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa12133
Middleton, R., Osborne, L., Noble, J., Lockhart-Jones, H., Middleton, R., Ellwood-Thompson, S., Maramba, I., Jones, K., Ford, D., & Noble, G. (2012). Sources of Discovery, Reasons for Registration, and Expectations of an Internet-Based Register for Multiple Sclerosis. International Journal of Healthcare Information Systems and Informatics, 7(3), 27-43.
https://doi.org/10.4018/jhisi.2012070103, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa12357
Middleton, R., Osborne, L., Lockhart-Jones, H., Middleton, R., Thompson, S., Maramba, I., Jones, K., Ford, D., Noble, J., & Noble, G. (2013). Identifying and Addressing the Barriers to the Use of an Internet-Register for Multiple Sclerosis. International Journal of Healthcare Information Systems and Informatics, 8(1)-16.
https://doi.org/10.4018/jhisi.2013010101, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa15161
Middleton, R., Osborne, L., Middleton, R., Jones, K., Ford, D., Noble, J., & Noble, G. (2013). Desirability and expectations of the UK MS Register: Views of people with MS. International Journal of Medical Informatics
https://doi.org/10.1016/j.ijmedinf.2013.07.005, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa15873
http://www.sciencedirect.com/science/article/pii/S1386505613001603
Evangelou, N., Garjani, A., dasNair, R., Hunter, R., Tuite-Dalton, K., Craig, E., Rodgers, J., Coles, A., Dobson, R., Duddy, M., Ford, D., Hughes, S., Pearson, O., Middleton, L., Rog, D., Tallantyre, E., Friede, T., Middleton, R., & Nicholas, R. (2020). Self-diagnosed COVID-19 in people with multiple sclerosis: a community-based cohort of the UK MS Register. Journal of Neurology, Neurosurgery & Psychiatry, 92(1), 107-109.
https://doi.org/10.1136/jnnp-2020-324449, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56803
Garjani, A., Middleton, R., Hunter, R., Tuite-Dalton, K., Coles, A., Dobson, R., Duddy, M., Hughes, S., Pearson, O., Rog, D., Tallantyre, E., Nair, R., Nicholas, R., & Evangelou, N. (2021). COVID-19 is associated with new symptoms of multiple sclerosis that are prevented by disease modifying therapies. Multiple Sclerosis and Related Disorders, 52, 102939
https://doi.org/10.1016/j.msard.2021.102939, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56804
Garjani, A., Hunter, R., Law, G., Middleton, R., Tuite-Dalton, K., Dobson, R., Ford, D., Hughes, S., Pearson, O., Rog, D., Tallantyre, E., Nicholas, R., Morriss, R., Evangelou, N., & Nair, R. (2021). Mental health of people with multiple sclerosis during the COVID-19 outbreak: A prospective cohort and cross-sectional case–control study of the UK MS Register. Multiple Sclerosis Journal, 28(7), 135245852110204
https://doi.org/10.1177/13524585211020435, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa57028
Huang, Y., Rodgers, J., Middleton, R., Baheerathan, A., Tuite-Dalton, K., Ford, D., Nicholas, R., & Group, M. (2021). Willingness to receive a COVID-19 vaccine in people with multiple sclerosis - UK MS Register survey. Multiple sclerosis and related disorders, 55, 103175-103175.
https://doi.org/10.1016/j.msard.2021.103175, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa57795
Middleton, R., Craig, E., Rodgers, J., Tuite-Dalton, K., Garjani, A., Evangelou, N., Nair, R., Hunter, R., Tallantyre, E., Cauchi, M., Cairn, C., Paling, D., Fuller, S., McDonnell, G., Petheram, K., Liu, B., Nock, U., Ingram, G., Brownlee, W...., & Nicholas, R. (2021). COVID-19 in Multiple Sclerosis: Clinically reported outcomes from the UK Multiple Sclerosis Register. Multiple Sclerosis and Related Disorders, 56, 103317
https://doi.org/10.1016/j.msard.2021.103317, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa58395
Simpson-Yap, S., Brouwer, E., Kalincik, T., Rijke, N., Hillert, J., Walton, C., Edan, G., Moreau, Y., Spelman, T., Geys, L., Parciak, T., Gautrais, C., Lazovski, N., Pirmani, A., Ardeshirdavanai, A., Forsberg, L., Glaser, A., McBurney, R., Schmidt, H...., & Peeters, L. (2021). Associations of Disease-Modifying Therapies With COVID-19 Severity in Multiple Sclerosis. Neurology, 97(19), e1870-e1885.
https://doi.org/10.1212/wnl.0000000000012753, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa58429
Rodgers, J., Friede, T., Vonberg, F., Constantinescu, C., Coles, A., Chataway, J., Duddy, M., Emsley, H., Ford, H., Fisniku, L., Galea, I., Harrower, T., Hobart, J., Huseyin, H., Kipps, C., Marta, M., McDonnell, G., McLean, B., Pearson, O...., & Nicholas, R. (2022). The impact of smoking cessation on multiple sclerosis disease progression. Brain, 145(4), 1368-1378.
https://doi.org/10.1093/brain/awab385, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa58437
Das, J., Rog, D., Middleton, R., Rodgers, J., Fry, R., & Nicholas, R. (2022). The association between deprivation and the access to disease modifying therapies for multiple sclerosis: An England wide community-based study in the UK MS Register. Multiple Sclerosis and Related Disorders, 57, 103474
https://doi.org/10.1016/j.msard.2021.103474, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa59086
Garjani, A., Middleton, R., Nicholas, R., & Evangelou, N. (2022). Recovery From COVID-19 in Multiple Sclerosis: A Prospective and Longitudinal Cohort Study of the United Kingdom Multiple Sclerosis Register. Neurology - Neuroimmunology Neuroinflammation, 9(1), e1118
https://doi.org/10.1212/nxi.0000000000001118, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa59132
Peeters, L., Parciak, T., Walton, C., Geys, L., Moreau, Y., Brouwer, E., Raimondi, D., Pirmani, A., Kalincik, T., Edan, G., Simpson-Yap, S., Raedt, L., Dauxais, Y., Gautrais, C., Rodrigues, P., McKenna, L., Lazovski, N., Hillert, J., Forsberg, L...., & Rijke, N. (2020). COVID-19 in people with multiple sclerosis: A global data sharing initiative. Multiple Sclerosis Journal, 26(10), 1157-1162.
https://doi.org/10.1177/1352458520941485, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61475
Tuite-Dalton, K., Middleton, R., Tuite-Dalton, K., Baker, E., Stennett, A., Albor, C., & Schmierer, K. (2020). Can We Improve the Monitoring of People With Multiple Sclerosis Using Simple Tools, Data Sharing, and Patient Engagement?. Frontiers in Neurology, 11
https://doi.org/10.3389/fneur.2020.00464, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61476
Salter, A., Stahmann, A., Ellenberger, D., Fneish, F., Rodgers, J., Middleton, R., Nicholas, R., & Marrie, R. (2021). Data harmonization for collaborative research among MS registries: A case study in employment. Multiple Sclerosis Journal, 27(2), 281-289.
https://doi.org/10.1177/1352458520910499, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61477
Nicholas, R., Heaven, M., Middleton, R., Chevli, M., Pulikottil-Jacob, R., Jones, K., & Ford, D. (2020). Personal and societal costs of multiple sclerosis in the UK: A population-based MS Registry study. Multiple Sclerosis Journal - Experimental, Translational and Clinical, 6(1), 205521732090172
https://doi.org/10.1177/2055217320901727, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61478
Flachenecker, P., Buckow, K., Pugliatti, M., Kes, V., Battaglia, M., Boyko, A., Confavreux, C., Ellenberger, D., Eskic, D., Ford, D., Friede, T., Fuge, J., Glaser, A., Hillert, J., Holloway, E., Ioannidou, E., Kappos, L., Kasilingam, E., Koch-Henriksen, N...., & Consortium*), . (2014). Multiple sclerosis registries in Europe – results of a systematic survey. Multiple Sclerosis Journal, 20(11), 1523-1532.
https://doi.org/10.1177/1352458514528760, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61479
Middleton, R., Pearson, O., Ingram, G., Craig, E., Rodgers, J., Downing-Wood, H., Hill, J., Tuite-Dalton, K., Roberts, C., Watson, L., Ford, D., Nicholas, R., & Group), . (2020). A Rapid Electronic Cognitive Assessment Measure for Multiple Sclerosis: Validation of Cognitive Reaction, an Electronic Version of the Symbol Digit Modalities Test. Journal of Medical Internet Research, 22(9), e18234
https://doi.org/10.2196/18234, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa55412
Middleton, R., Ford, D., & Naeh, D. (2017). iConsent an Electronic Consent Platform with the MS Register. In International Journal of Population Data ScienceSwansea University.
https://doi.org/10.23889/ijpds.v1i1.363, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa53023
Jones, K., Ford, D., Jones, P., John, A., Middleton, R., Lockhart-Jones, H., Peng, J., Osborne, L., & Noble, G. (2013). How People with Multiple Sclerosis Rate Their Quality of Life: An EQ-5D Survey via the UK MS Register. PLoS ONE, 8(6), e65640
https://doi.org/10.1371/journal.pone.0065640, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa16841
Jones, K., Ford, D., Jones, P., John, A., Middleton, R., Lockhart-Jones, H., Peng, J., Osborne, L., Noble, G., & Jones, P. (2013). The Physical and Psychological Impact of Multiple Sclerosis Using the MSIS-29 via the Web Portal of the UK MS Register. PLoS ONE, 8(1), e55422
https://doi.org/10.1371/journal.pone.0055422, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa16846
Jones, K., Ford, D., Jones, P., John, A., Middleton, R., Lockhart-Jones, H., Osborne, L., & Noble, G. (2012). A Large-Scale Study of Anxiety and Depression in People with Multiple Sclerosis: A Survey via the Web Portal of the UK MS Register. PLoS ONE, 7(7), e41910
https://doi.org/10.1371/journal.pone.0041910, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa16849

All Research

Journal Articles

Nicholas, R., Tallantyre, E., Witts, J., Marrie, R., Craig, E., Knowles, S., Pearson, O., Harding, K., Kreft, K., Hawken, J., Ingram, G., Morgan, B., Middleton, R., Robertson, N., & Group, U. (2024). Algorithmic approach to finding people with multiple sclerosis using routine healthcare data in Wales. Journal of Neurology, Neurosurgery and Psychiatry, 95(11), 1032-1035.
https://doi.org/10.1136/jnnp-2024-333532, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa66529
Rad, E., Saboori, S., Tektonidis, T., Simpson-Yap, S., Reece, J., Hebert, J., Nicholas, R., Middleton, R., Tammam, J., Black, L., & Coe, S. (2024). A systematic review and meta-analysis of Dietary Inflammatory Index and the likelihood of multiple sclerosis/ demyelinating autoimmune disease. Clinical Nutrition ESPEN, 62, 108-114.
https://doi.org/10.1016/j.clnesp.2024.04.022, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa68038
http://dx.doi.org/10.1016/j.clnesp.2024.04.022
Thomason, S., Moghaddam, N., Evangelou, N., Middleton, R., & Nair, R. (2024). Barriers and strategies to medication adherence amongst people with multiple sclerosis and cognitive problems. Multiple Sclerosis and Related Disorders, 88, 105727
https://doi.org/10.1016/j.msard.2024.105727, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa68037
http://dx.doi.org/10.1016/j.msard.2024.105727
Knowles, S., Middleton, R., Cooze, B., Farkas, I., Leung, Y., Allen, K., WINSLADE, M., Owen, D., Magliozzi, R., Reynolds, R., Neal, J., Pearson, O., Nicholas, R., Pickrell, O., Howell, O., & Group), . (2024). Comparing the Pathology, Clinical, and Demographic Characteristics of Younger and Older‐Onset Multiple Sclerosis. Annals of Neurology, 95(3), 471-486.
https://doi.org/10.1002/ana.26843, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa65353
http://dx.doi.org/10.1002/ana.26843
Das, J., Rog, D., Middleton, R., Rodgers, J., & Nicholas, R. (2024). University education facilitates uptake of disease-modifying therapies for multiple sclerosis: A community-based study using the UK MS Register. Multiple Sclerosis Journal, 30(2), 192-199.
https://doi.org/10.1177/13524585231221411, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa68040
http://dx.doi.org/10.1177/13524585231221411
Nicholas, R., Rodgers, J., Witts, J., Lerede, A., Friede, T., Hillert, J., Forsberg, L., Glaser, A., Manouchehrinia, A., Ramanujam, R., Spelman, T., Klyve, P., Drahota, J., Horakova, D., Joensen, H., Pontieri, L., Magyari, M., Ellenberger, D., Stahmann, A...., & Middleton, R. (2023). The impact of healthcare systems on the clinical diagnosis and disease-modifying treatment usage in relapse-onset multiple sclerosis: a real-world perspective in five registries across Europe. Therapeutic Advances in Neurological Disorders, 16
https://doi.org/10.1177/17562864231198963, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa66408
Lerede, A., Rodgers, J., Middleton, R., Hampshire, A., Nicholas, R., Coles, A., Chataway, J., Duddy, M., Emsley, H., Ford, H., Fisniku, L., Galea, I., Harrower, T., Hobart, J., Huseyin, H., Kipps, C., Marta, M., McDonnell, G., McLean, B...., & Group), . (2023). Patient-reported outcomes in multiple sclerosis: a prospective registry cohort study. Brain Communications, 5(4)
https://doi.org/10.1093/braincomms/fcad199, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa66407
Meek, C., Nair, R., Evangelou, N., Middleton, R., Tuite-Dalton, K., & Moghaddam, N. (2022). Psychological flexibility, distress, and quality of life in secondary progressive multiple sclerosis: A cross-sectional study. Multiple Sclerosis and Related Disorders, 67, 104154
https://doi.org/10.1016/j.msard.2022.104154, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61481
Frahm, N., Fneish, F., Ellenberger, D., Haas, J., Loebermann, M., Parciak, T., Peters, M., Pöhlau, D., Rodgers, J., Röper, A., Schilling, S., Stahmann, A., Temmes, H., Zettl, U., & Middleton, R. (2022). SARS-CoV-2 vaccination in patients with multiple sclerosis in Germany and the United Kingdom: Gender-specific results from a longitudinal observational study. The Lancet Regional Health - Europe, 22, 100502
https://doi.org/10.1016/j.lanepe.2022.100502, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61480
Kamudoni, P., Johns, J., Cook, K., Salem, R., Salek, S., Raab, J., Middleton, R., Henke, C., & Amtmann, D. (2022). A comparison of the measurement properties of the PROMIS Fatigue (MS) 8a against legacy fatigue questionnaires. Multiple Sclerosis and Related Disorders, 66, 104048
https://doi.org/10.1016/j.msard.2022.104048, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61483
Simpson-Yap, S., Pirmani, A., Brouwer, E., Peeters, L., Geys, L., Parciak, T., Helme, A., Hillert, J., Moreau, Y., Edan, G., Spelman, T., Sharmin, S., McBurney, R., Schmidt, H., Bergmann, A., Braune, S., Stahmann, A., Middleton, R., Salter, A...., & Kalincik, T. (2022). Severity of COVID19 infection among patients with multiple sclerosis treated with interferon-β. Multiple Sclerosis and Related Disorders, 66, 104072
https://doi.org/10.1016/j.msard.2022.104072, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61482
Moore, H., Nair, K., Baster, K., Middleton, R., Paling, D., & Sharrack, B. (2022). Fatigue in multiple sclerosis: A UK MS-register based study. Multiple Sclerosis and Related Disorders, 64, 103954
https://doi.org/10.1016/j.msard.2022.103954, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61484
Kamudoni, P., Amtmann, D., Johns, J., Cook, K., Salem, R., Salek, S., Raab, J., Middleton, R., Repovic, P., Alschuler, K., Geldern, G., Wundes, A., Barrett, A., Olayinka-Amao, O., & Henke, C. (2022). The validity, responsiveness, and score interpretation of the PROMISnq Physical Function – Multiple Sclerosis 15a short form in multiple sclerosis. Multiple Sclerosis and Related Disorders, 62, 103753
https://doi.org/10.1016/j.msard.2022.103753, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61485
Garjani, A., Middleton, R., Law, G., Tuite-Dalton, K., Hunter, R., Nair, R., Evangelou, N., & Nicholas, R. (2022). COVID-19 and multiple sclerosis: An updated report of the community-based longitudinal UK MS Register study. Journal of Neurology, Neurosurgery and Psychiatry, 93(6), A93.2-A93.
https://doi.org/10.1136/jnnp-2022-abn.302, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa62047
Ellenberger, D., Parciak, T., Brola, W., Hillert, J., Middleton, R., Stahmann, A., Thalheim, C., & Flachenecker, P. (2022). Comparison of employment among people with Multiple Sclerosis across Europe. Multiple Sclerosis Journal - Experimental, Translational and Clinical, 8(2), 205521732210906
https://doi.org/10.1177/20552173221090653, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61486
Rodgers, J., Friede, T., Vonberg, F., Constantinescu, C., Coles, A., Chataway, J., Duddy, M., Emsley, H., Ford, H., Fisniku, L., Galea, I., Harrower, T., Hobart, J., Huseyin, H., Kipps, C., Marta, M., McDonnell, G., McLean, B., Pearson, O...., & Nicholas, R. (2022). The impact of smoking cessation on multiple sclerosis disease progression. Brain, 145(4), 1368-1378.
https://doi.org/10.1093/brain/awab385, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa58437
Das, J., Rog, D., Middleton, R., Rodgers, J., Fry, R., & Nicholas, R. (2022). The association between deprivation and the access to disease modifying therapies for multiple sclerosis: An England wide community-based study in the UK MS Register. Multiple Sclerosis and Related Disorders, 57, 103474
https://doi.org/10.1016/j.msard.2021.103474, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa59086
Garjani, A., Middleton, R., Nicholas, R., & Evangelou, N. (2022). Recovery From COVID-19 in Multiple Sclerosis: A Prospective and Longitudinal Cohort Study of the United Kingdom Multiple Sclerosis Register. Neurology - Neuroimmunology Neuroinflammation, 9(1), e1118
https://doi.org/10.1212/nxi.0000000000001118, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa59132
Simpson-Yap, S., Brouwer, E., Kalincik, T., Rijke, N., Hillert, J., Walton, C., Edan, G., Moreau, Y., Spelman, T., Geys, L., Parciak, T., Gautrais, C., Lazovski, N., Pirmani, A., Ardeshirdavanai, A., Forsberg, L., Glaser, A., McBurney, R., Schmidt, H...., & Peeters, L. (2021). Associations of Disease-Modifying Therapies With COVID-19 Severity in Multiple Sclerosis. Neurology, 97(19), e1870-e1885.
https://doi.org/10.1212/wnl.0000000000012753, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa58429
Middleton, R., Craig, E., Rodgers, J., Tuite-Dalton, K., Garjani, A., Evangelou, N., Nair, R., Hunter, R., Tallantyre, E., Cauchi, M., Cairn, C., Paling, D., Fuller, S., McDonnell, G., Petheram, K., Liu, B., Nock, U., Ingram, G., Brownlee, W...., & Nicholas, R. (2021). COVID-19 in Multiple Sclerosis: Clinically reported outcomes from the UK Multiple Sclerosis Register. Multiple Sclerosis and Related Disorders, 56, 103317
https://doi.org/10.1016/j.msard.2021.103317, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa58395
Huang, Y., Rodgers, J., Middleton, R., Baheerathan, A., Tuite-Dalton, K., Ford, D., Nicholas, R., & Group, M. (2021). Willingness to receive a COVID-19 vaccine in people with multiple sclerosis - UK MS Register survey. Multiple sclerosis and related disorders, 55, 103175-103175.
https://doi.org/10.1016/j.msard.2021.103175, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa57795
Garjani, A., Middleton, R., Hunter, R., Tuite-Dalton, K., Coles, A., Dobson, R., Duddy, M., Hughes, S., Pearson, O., Rog, D., Tallantyre, E., Nair, R., Nicholas, R., & Evangelou, N. (2021). COVID-19 is associated with new symptoms of multiple sclerosis that are prevented by disease modifying therapies. Multiple Sclerosis and Related Disorders, 52, 102939
https://doi.org/10.1016/j.msard.2021.102939, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56804
Nair, R., Hunter, R., Garjani, A., Middleton, R., Tuite-Dalton, K., Nicholas, R., & Evangelou, N. (2021). Challenges of developing, conducting, analysing and reporting a COVID-19 study as the COVID-19 pandemic unfolds: an online co-autoethnographic study. BMJ Open, 11(6), e048788
https://doi.org/10.1136/bmjopen-2021-048788, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa65365
http://dx.doi.org/10.1136/bmjopen-2021-048788
Garjani, A., Hunter, R., Law, G., Middleton, R., Tuite-Dalton, K., Dobson, R., Ford, D., Hughes, S., Pearson, O., Rog, D., Tallantyre, E., Nicholas, R., Morriss, R., Evangelou, N., & Nair, R. (2021). Mental health of people with multiple sclerosis during the COVID-19 outbreak: A prospective cohort and cross-sectional case–control study of the UK MS Register. Multiple Sclerosis Journal, 28(7), 135245852110204
https://doi.org/10.1177/13524585211020435, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa57028
Salter, A., Stahmann, A., Ellenberger, D., Fneish, F., Rodgers, J., Middleton, R., Nicholas, R., & Marrie, R. (2021). Data harmonization for collaborative research among MS registries: A case study in employment. Multiple Sclerosis Journal, 27(2), 281-289.
https://doi.org/10.1177/1352458520910499, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61477
Coe, S., Tektonidis, T., Coverdale, C., Penny, S., Collett, J., Chu, B., Izadi, H., Middleton, R., & Dawes, H. (2021). A cross sectional assessment of nutrient intake and the association of the inflammatory properties of nutrients and foods with symptom severity in a large cohort from the UK Multiple Sclerosis Registry. Nutrition Research, 85, 31-39.
https://doi.org/10.1016/j.nutres.2020.11.006, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61488
Vickaryous, N., Jitlal, M., Jacobs, B., Middleton, R., Chandran, S., MacDougall, N., Giovannoni, G., & Dobson, R. (2020). Remote testing of vitamin D levels across the UK MS population—A case control study. PLOS ONE, 15(12), e0241459
https://doi.org/10.1371/journal.pone.0241459, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61487
Evangelou, N., Garjani, A., dasNair, R., Hunter, R., Tuite-Dalton, K., Craig, E., Rodgers, J., Coles, A., Dobson, R., Duddy, M., Ford, D., Hughes, S., Pearson, O., Middleton, L., Rog, D., Tallantyre, E., Friede, T., Middleton, R., & Nicholas, R. (2020). Self-diagnosed COVID-19 in people with multiple sclerosis: a community-based cohort of the UK MS Register. Journal of Neurology, Neurosurgery & Psychiatry, 92(1), 107-109.
https://doi.org/10.1136/jnnp-2020-324449, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56803
Middleton, R., Pearson, O., Ingram, G., Craig, E., Rodgers, J., Downing-Wood, H., Hill, J., Tuite-Dalton, K., Roberts, C., Watson, L., Ford, D., Nicholas, R., & Group), . (2020). A Rapid Electronic Cognitive Assessment Measure for Multiple Sclerosis: Validation of Cognitive Reaction, an Electronic Version of the Symbol Digit Modalities Test. Journal of Medical Internet Research, 22(9), e18234
https://doi.org/10.2196/18234, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa55412
Peeters, L., Parciak, T., Walton, C., Geys, L., Moreau, Y., Brouwer, E., Raimondi, D., Pirmani, A., Kalincik, T., Edan, G., Simpson-Yap, S., Raedt, L., Dauxais, Y., Gautrais, C., Rodrigues, P., McKenna, L., Lazovski, N., Hillert, J., Forsberg, L...., & Rijke, N. (2020). COVID-19 in people with multiple sclerosis: A global data sharing initiative. Multiple Sclerosis Journal, 26(10), 1157-1162.
https://doi.org/10.1177/1352458520941485, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61475
Tuite-Dalton, K., Middleton, R., Tuite-Dalton, K., Baker, E., Stennett, A., Albor, C., & Schmierer, K. (2020). Can We Improve the Monitoring of People With Multiple Sclerosis Using Simple Tools, Data Sharing, and Patient Engagement?. Frontiers in Neurology, 11
https://doi.org/10.3389/fneur.2020.00464, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61476
Nicholas, R., Heaven, M., Middleton, R., Chevli, M., Pulikottil-Jacob, R., Jones, K., & Ford, D. (2020). Personal and societal costs of multiple sclerosis in the UK: A population-based MS Registry study. Multiple Sclerosis Journal - Experimental, Translational and Clinical, 6(1), 205521732090172
https://doi.org/10.1177/2055217320901727, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61478
Glaser, A., Stahmann, A., Meissner, T., Flachenecker, P., Horáková, D., Zaratin, P., Brichetto, G., Pugliatti, M., Rienhoff, O., Vukusic, S., de Giacomoni, A., Battaglia, M., Brola, W., Butzkueven, H., Casey, R., Drulovic, J., Eichstädt, K., Hellwig, K., Iaffaldano, P...., & Middleton, R. (2019). Multiple sclerosis registries in Europe – An updated mapping survey. Multiple Sclerosis and Related Disorders, 27, 171-178.
https://doi.org/10.1016/j.msard.2018.09.032, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa45469
Middleton, R., Rodgers, W., Chataway, J., Schmierer, K., Rog, D., Galea, I., Akbari, A., Tuite-Dalton, K., Lockhart-Jones, H., Griffiths, D., Noble, D., Jones, K., Al-Din, A., Craner, M., Evangelou, N., Harman, P., Harrower, T., Hobart, J., Husseyin, H...., & Ford, D. (2018). Validating the portal population of the United Kingdom Multiple Sclerosis Register. Multiple Sclerosis and Related Disorders, 24, 3-10.
https://doi.org/10.1016/j.msard.2018.05.015, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa40629
Middleton, R., Rodgers, J., Giovannoni, G., Schmierer, K., Dobson, R., Allen-Philbey, K., Patterson, A., Tuite-Dalton, K., Ford, D., & Akbari, A. (2017). A Comparison of participant supplied EDSS scores and clinically submitted data via the UK MS Register. Multiple Sclerosis Journal, 23(3_suppl), 85-426.
https://doi.org/10.1177/1352458517731404, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa39440
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000413730200236&KeyUID=WOS:000413730200236
Lacey, A., Lyons, J., Akbari, A., Turner, S., Walters, A., Fonferko-Shadrach, B., Pickrell, O., Rees, M., Lyons, R., Ford, D., & Middleton, R. (2017). Codifying unstructured data: A Natural Language Processing approach to extract rich data from clinical letters. International Journal for Population Data Science, 1(1)
https://doi.org/10.23889/ijpds.v1i1.354, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa39437
Middleton, R., Akbari, A., Lockhart-Jones, H., Jones, J., Owen, C., Hughes, S., Gain, R., & Ford, D. (2017). Clinical Validation of the UKMS Register Minimal Dataset utilising Natural Language Processing. International Journal of Population Data Science, 1(1)
https://doi.org/10.23889/ijpds.v1i1.288, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa39436
Baker, D., Anandhakrishnan, A., Tuite-Dalton, K., Lockhart-Jones, H., Middleton, R., Ford, D., Crowe, C., & Giovannoni, G. (2016). How to refer to people with disease in research outputs: The disconnection between academic practise and that preferred by people with multiple sclerosis. Multiple Sclerosis and Related Disorders, 10, 127-133.
https://doi.org/10.1016/j.msard.2016.09.007, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32027
Middleton, R., Ford, D., Akbari, A., Lockhart-Jones, H., Jones, J., Hughes, S., & Owen, C. (2016). Natural language processing to capture MS clinical data. Multiple Sclerosis Journal, 22(3_suppl), 717-717.
https://doi.org/10.1177/1352458516663067, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa44549
Middleton, R., Balbuena, L., Middleton, R., Tuite-Dalton, K., Pouliou, T., Williams, K., & Noble, G. (2016). Sunshine, Sea, and Season of Birth: MS Incidence in Wales. PLOS ONE, 11(5), e0155181
https://doi.org/10.1371/journal.pone.0155181, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa29587
Flachenecker, P., Buckow, K., Pugliatti, M., Kes, V., Battaglia, M., Boyko, A., Confavreux, C., Ellenberger, D., Eskic, D., Ford, D., Friede, T., Fuge, J., Glaser, A., Hillert, J., Holloway, E., Ioannidou, E., Kappos, L., Kasilingam, E., Koch-Henriksen, N...., & Consortium*), . (2014). Multiple sclerosis registries in Europe – results of a systematic survey. Multiple Sclerosis Journal, 20(11), 1523-1532.
https://doi.org/10.1177/1352458514528760, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61479
Jones, K., Jones, P., Middleton, R., Ford, D., Tuite-Dalton, K., Lockhart-Jones, H., Peng, J., Lyons, R., John, A., & Noble, G. (2014). Physical Disability, Anxiety and Depression in People with MS: An Internet-Based Survey via the UK MS Register. PLoS ONE, 9(8), e104604
https://doi.org/10.1371/journal.pone.0104604, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa18808
https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0104604&type=printable
Osborne, L., Noble, G., Maramba, I., Jones, K., Middleton, R., Lyons, R., Ford, D., & Reed, P. (2014). Outcome measures for multiple sclerosis. Physical Therapy Reviews, 19(1), 24-38.
https://doi.org/10.1179/1743288x13y.0000000094, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa18316
Middleton, R., Osborne, L., Middleton, R., Jones, K., Ford, D., Noble, J., & Noble, G. (2013). Desirability and expectations of the UK MS Register: Views of people with MS. International Journal of Medical Informatics
https://doi.org/10.1016/j.ijmedinf.2013.07.005, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa15873
http://www.sciencedirect.com/science/article/pii/S1386505613001603
Jones, K., Ford, D., Jones, P., John, A., Middleton, R., Lockhart-Jones, H., Peng, J., Osborne, L., & Noble, G. (2013). How People with Multiple Sclerosis Rate Their Quality of Life: An EQ-5D Survey via the UK MS Register. PLoS ONE, 8(6), e65640
https://doi.org/10.1371/journal.pone.0065640, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa16841
Middleton, R., Osborne, L., Lockhart-Jones, H., Middleton, R., Thompson, S., Maramba, I., Jones, K., Ford, D., Noble, J., & Noble, G. (2013). Identifying and Addressing the Barriers to the Use of an Internet-Register for Multiple Sclerosis. International Journal of Healthcare Information Systems and Informatics, 8(1)-16.
https://doi.org/10.4018/jhisi.2013010101, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa15161
Jones, K., Ford, D., Jones, P., John, A., Middleton, R., Lockhart-Jones, H., Peng, J., Osborne, L., Noble, G., & Jones, P. (2013). The Physical and Psychological Impact of Multiple Sclerosis Using the MSIS-29 via the Web Portal of the UK MS Register. PLoS ONE, 8(1), e55422
https://doi.org/10.1371/journal.pone.0055422, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa16846
Middleton, R., Ford, D., Jones, K., Middleton, R., Lockhart-Jones, H., Maramba, I., Noble, G., Osborne, L., & Lyons, R. (2012). The feasibility of collecting information from people with Multiple Sclerosis for the UK MS Register via a web portal: characterising a cohort of people with MS. BMC Medical Informatics and Decision Making, 12(1), 73
https://doi.org/10.1186/1472-6947-12-73, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa11798
Middleton, R., Noble, J., Osborne, L., Jones, K., Middleton, R., Ford, D., Noble, G., Jones, K., & Ford, D. (2012). Commentary on 'Disability outcome measures in multiple sclerosis clinical trials'. Multiple Sclerosis Journal, 18(12), 1718-1720.
https://doi.org/10.1177/1352458512457847, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa12133
Middleton, R., Osborne, L., Noble, J., Lockhart-Jones, H., Middleton, R., Ellwood-Thompson, S., Maramba, I., Jones, K., Ford, D., & Noble, G. (2012). Sources of Discovery, Reasons for Registration, and Expectations of an Internet-Based Register for Multiple Sclerosis. International Journal of Healthcare Information Systems and Informatics, 7(3), 27-43.
https://doi.org/10.4018/jhisi.2012070103, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa12357
Jones, K., Ford, D., Jones, P., John, A., Middleton, R., Lockhart-Jones, H., Osborne, L., & Noble, G. (2012). A Large-Scale Study of Anxiety and Depression in People with Multiple Sclerosis: A Survey via the Web Portal of the UK MS Register. PLoS ONE, 7(7), e41910
https://doi.org/10.1371/journal.pone.0041910, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa16849
Giovannoni, G., Ford, H., Schmierer, K., Middleton, R., Stennett, A., Pomeroy, I., Fisniku, L., Scalfari, A., Bannon, C., Stross, R., Hughes, S., Williams, A., Josephs, S., Peel, C., & Straukiene, A. (n.d.) MS care: integrating advanced therapies and holistic management. Frontiers in Neurology, 14
https://doi.org/10.3389/fneur.2023.1286122, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa68039
http://dx.doi.org/10.3389/fneur.2023.1286122
Zaratin, P., Samadzadeh, S., Seferoğlu, M., Ricigliano, V., Silva, J., Tunc, A., Brichetto, G., Coetzee, T., Helme, A., Khan, U., McBurney, R., Peryer, G., Weiland, H., Baneke, P., Battaglia, M., Block, V., Capezzuto, L., Carment, L., Cortesi, P...., & Vermersch, P. (n.d.) The global patient-reported outcomes for multiple sclerosis initiative: bridging the gap between clinical research and care – updates at the 2023 plenary event. Frontiers in Neurology, 15
https://doi.org/10.3389/fneur.2024.1407257, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa68036
http://dx.doi.org/10.3389/fneur.2024.1407257

Conference Contributions

Middleton, R., Craig, E., Rodgers, W., Tuite-Dalton, K., Garjani, A., Evangelou, N., Hunter, R., DasNair, R., & Nicholas, R. (2022). 096 COVID-19 in MS: clinically reported outcomes from the UK MS register. In Journal of Neurology, Neurosurgery and Psychiatry (pp. A130.3-A130). BMJ.
https://doi.org/10.1136/jnnp-2022-abn.421, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa62044
Middleton, R., Allen-Philby, K., Schmierer, K., Espasandin, M., C.Roberts, ., Nicholas, R., Rodgers, J., Lockhart-Jones, H., Tuite-Dalton, K., & Ford, D. (2019). 175 A model for participant engagement in research: the MS register. In Journal of Neurology, Neurosurgery and Psychiatry (pp. e46BMJ.
https://doi.org/10.1136/jnnp-2019-ABN-2.155, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61927
https://jnnp.bmj.com/content/90/12/e46.3.info
Middleton, R., Ford, D., & Naeh, D. (2017). iConsent an Electronic Consent Platform with the MS Register. In International Journal of Population Data ScienceSwansea University.
https://doi.org/10.23889/ijpds.v1i1.363, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa53023

Taught Modules

PMIM401 Systems and Technologies

In this module, students will study the information systems & technologies used in health informatics projects and their implementation. These include: networks; the Internet; integrated communications; mobile communications; health information systems. Academic skills are further developed by studying how systematic reviews of literature are undertaken.

Key Grants and Projects

UK MS Register 2022 - 2027

, £1,999,794
PROMIS-3 Outcome Measures in MS 2022 - 2025

, £245,511.88
OCTOPUS: A multi-arm, multi-stage trial for progressive MS 2021 - 2029

, £97,952
NeuroMS : Neurological Evaluation and Rehabilitation in MS 2020 - 2023

, £97,952

Career History

Associate Professor , Swansea University

August 2022 - Present
System Architect Project Manager, Swansea University

February 2010 - August 2022
Clinical Systems Manager, Critical Care and Theatres, Cwm Taf NHS Trust, Llantrisant

September 2003 - February 2010
Staff Nurse, Senior Staff Nurse, Charge Nurse , Various NHS Trusts

September 1996 - February 2003

Other Roles

Committee Member , Register Collaboration Network in Secondary Progressive MS

2019 - Present
Advisor, MSDA

2020 - Present

Dr Rod Middleton

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PMIM401 Systems and Technologies

PROMIS-3 Outcome Measures in MS 2022 - 2025

Associate Professor , Swansea University

System Architect Project Manager, Swansea University

Clinical Systems Manager, Critical Care and Theatres, Cwm Taf NHS Trust, Llantrisant

Staff Nurse, Senior Staff Nurse, Charge Nurse , Various NHS Trusts

Committee Member , Register Collaboration Network in Secondary Progressive MS

Advisor, MSDA